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3D printed nanoparticle biosensing platform detects SARS-CoV-2 antibodies within seconds

Pandemics caused by novel infectious agents like the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Zika, or Ebola virus seriously impact human health and lives while also overwhelming health care systems all over the world. Early detection and diagnosis allow isolation of the infected patients and contact tracing, which can mitigate the spread of the virus and save lives, especially when a significant number of the patients are asymptomatic.

14 Sep 2020

Tiny antibody component shows high potency in SARS-CoV-2 animal models

University of Pittsburgh School of Medicine scientists have isolated the smallest biological molecule to date that completely and specifically neutralizes the SARS-CoV-2 virus, which is the cause of COVID-19.

14 Sep 2020

New review explores the role of antibodies and T-cells towards an effective COVID vaccine

More than 100 companies have rushed into vaccine development against COVID-19 as the U.S. government pushes for a vaccine rollout at "warp speed" -- possibly by the end of the year -- but the bar set for an effective, long-lasting vaccine is far too low and may prove dangerous, according to Marc Hellerstein of the University of California, Berkeley.

11 Sep 2020

New antitumor vaccines control melanoma growth in preclinical models

Combining their expertise in protein engineering and synthetic DNA technology, scientists at The Wistar Institute successfully delivered nanoparticle antitumor vaccines that stimulated robust CD8 T cell immunity and controlled melanoma growth in preclinical models.

11 Sep 2020

Antibiotic molecule helps the body's own immune system to kill HIV infected cells

Ever since the first cases of a mysterious disease in the early 1980s exploded into the HIV/AIDS pandemic, researchers have been searching for ways to outsmart the deadly virus.

11 Sep 2020

New book gives overview of viruses and how they emerge to cause pandemics

Since the novel coronavirus SARS-Cov-2 emerged late last year, it has been virtually impossible to consume any news without encountering stories about the virus and how it spreads, potential treatments, and the development of new vaccines.

11 Sep 2020

Effective, simple, safe self-amplifying RNA vaccines

A recent review paper in the journal Current Opinion in Virology in September 2020 shows how a new generation of RNA vaccines called self-amplifying RNA vaccines are more potent than conventional mRNA vaccines and could hold the key to the global production of cost-effective potent COVID-19 vaccines.

11 Sep 2020

Male circumcision campaigns to reduce HIV transmission in Africa are based on systemic racism

World Health Organization-recommended campaigns to circumcise millions of African boys and men to reduce HIV transmission are based more on systemic racism and 'neocolonialism' than sound scientific research, according to a critical appraisal published in Developing World Bioethics.

10 Sep 2020

DLnano-vaccines may be a promising strategy for cancer immunotherapy

Researchers designed DLnano-vaccines displaying 60 copies of protein parts derived from the melanoma-specific antigens Trp2 and Gp100 and tested these in mouse models of melanoma, observing prolonged survival that depended on CD8 T cell activation both in therapeutic and prophylactic settings.

10 Sep 2020

Fungi can develop drug resistance without genetic changes

The management of fungal infections in plants and humans could be transformed by a breakthrough in understanding how fungi develop resistance to drugs.

9 Sep 2020

Researchers discover a new way to limit inflammation from adjuvants in vaccines

Adjuvants are a key ingredient of many modern vaccines, working to unleash an immune response that helps protect the body from disease. Many scientists believe that adjuvants are they key to developing new kinds of vaccines for hard-to-vaccinate viruses, like HIV.

9 Sep 2020

State-level policies are crucial to HIV prevention efforts

HIV prevention remains a public health priority in the United States. Pre-exposure prophylaxis (PrEP) is a drug regimen recommended for individuals who have engaged in behaviors that place them at elevated risk for HIV.

9 Sep 2020

Antibody-mediated platelet death linked to COVID-19 severity

A new study by University of Tuebingen researchers shows the strong association between platelet apoptosis and the thrombotic manifestations that may underlie critical COVID-19 illness.

7 Sep 2020

Consortium compiles recommendations for measuring HIV reservoir size in cure-directed studies

Spearheaded by scientists at The Wistar Institute, top worldwide HIV researchers from the BEAT-HIV Martin Delaney Collaboratory to Cure HIV-1 Infection by Combination Immunotherapy compiled the first comprehensive set of recommendations on how to best measure the size of persistent HIV reservoirs during cure-directed clinical studies.

7 Sep 2020

COVID-19 caused substantial disruptions to essential health services in most countries

The COVID-19 pandemic caused substantial disruptions in essential health services in 9 out of 10 countries surveyed by WHO.

7 Sep 2020

UChicago Medicine launches clinical trial to test the potential of antibody against SARS-CoV-2

The University of Chicago Medicine is launching a clinical trial to examine the potential of an antibody against the SARS-CoV-2 spike protein for treating COVID-19, the disease caused by the novel coronavirus.

3 Sep 2020

Two MDC scientists win ERC Starting Grants for pioneering research

Dr. Kathrin de la Rosa and Dr. Ilaria Piazza, who are both junior group leaders at the Max DelbruÌ-ck Center for Molecular Medicine in the Helmholtz Association, have each won European Research Council Starting Grants.

3 Sep 2020

Reformulated generic drug could offer a cost-effective way to accelerate recovery, prevent hospitalizations

Reformulated and patented version of well-known generic drug could prove to be a quick, safe and cost-effective way to accelerate recovery and prevent hospitalizations.

3 Sep 2020

HIV and HCV testing at drug detoxification centers can help identify persons at-risk during opioid epidemic

With an increase in HIV and HCV infections as a consequence of the ongoing opioid epidemic, Boston Medical Center researchers found that only a small number of those who test positive for those infections at a drug detoxification center followed up for a clinical visit after their test.

3 Sep 2020

VUMC launches clinical trial of promising COVID-19 treatments in outpatient setting

Vanderbilt University Medical Center is launching a clinical trial of promising treatments for COVID-19 in the outpatient setting.

2 Sep 2020

HIV News and Research

3D printed nanoparticle biosensing platform detects SARS-CoV-2 antibodies within seconds

Tiny antibody component shows high potency in SARS-CoV-2 animal models

New review explores the role of antibodies and T-cells towards an effective COVID vaccine

New antitumor vaccines control melanoma growth in preclinical models

Antibiotic molecule helps the body's own immune system to kill HIV infected cells

New book gives overview of viruses and how they emerge to cause pandemics

Effective, simple, safe self-amplifying RNA vaccines

Male circumcision campaigns to reduce HIV transmission in Africa are based on systemic racism

DLnano-vaccines may be a promising strategy for cancer immunotherapy

Fungi can develop drug resistance without genetic changes

Researchers discover a new way to limit inflammation from adjuvants in vaccines

State-level policies are crucial to HIV prevention efforts

Antibody-mediated platelet death linked to COVID-19 severity

Consortium compiles recommendations for measuring HIV reservoir size in cure-directed studies

COVID-19 caused substantial disruptions to essential health services in most countries

UChicago Medicine launches clinical trial to test the potential of antibody against SARS-CoV-2

Two MDC scientists win ERC Starting Grants for pioneering research

Reformulated generic drug could offer a cost-effective way to accelerate recovery, prevent hospitalizations

HIV and HCV testing at drug detoxification centers can help identify persons at-risk during opioid epidemic

VUMC launches clinical trial of promising COVID-19 treatments in outpatient setting

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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