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Scientists develop and test a new model of traumatic brain injury in zebrafish

A group of scientists, which included researchers from the Ural Federal University (UrFU), have developed and successfully tested a new model of traumatic brain injury (TBI) in zebrafish.

15 Sep 2022

STRATAGEM aims to provide new perspectives on multidrug-resistant solid tumors

Achieving a good efficacy of chemotherapy is one of the major challenges still unresolved in oncological patients. The main limitation to the efficacy of chemotherapy is the multidrug-resistant (MDR) phenotype, a multiple cross-resistance towards different anticancer drugs.

14 Sep 2022

Prenatal cannabis exposure linked with mental health problems that persist into early adolescence

Prenatal cannabis exposure following the middle of the first trimester—generally after five to six weeks of fetal development—is associated with attention, social, and behavioral problems that persist as the affected children progress into early adolescence (11 and 12 years of age), according to new research supported by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health.

12 Sep 2022

Can cod liver oil supplementation prevent COVID-19 and other acute respiratory infections?

A new study aimed to analyze whether cod liver oil could prevent serious COVID-19, SARS-CoV-2 infection, or other acute respiratory infections during the winter of 2020-2021.

9 Sep 2022

Can preclinical COVID-19 models help unlock mystery of long-COVID?

In a recently published article in the journal PLOS PATHOGENS, scientists have summarized acute and prolonged clinical manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The review also provides an overview of the potency and utility of preclinical animal models to understand the mechanistic details of acute and long coronavirus disease 2019 (COVID-19).

8 Sep 2022

Low-dose ketamine is safe and effective to treat children with ADNP syndrome, study suggests

Results of a small, but unique research study, led by researchers from the Seaver Autism Center for Research and Treatment at Mount Sinai and published online in Human Genetics and Genomic Advances, suggest that low-dose ketamine is generally safe, well-tolerated and effective to treat clinical symptoms in children diagnosed with ADNP syndrome (also known as Helsmoortel-VanDerAa syndrome), a rare neurodevelopmental disorder caused by mutations in the activity dependent neuroprotective protein (ADNP) gene.

6 Sep 2022

PhoreMost enters multi-project drug target discovery collaboration with Roche

PhoreMost to deploy its SITESEEKER platform to identify novel targets for Roche’s discovery programmes

From PhoreMost 6 Sep 2022

High-quality human clinical trials needed to determine the benefits of CBD for heart disease patients

As cannabidiol (CBD) use rises, high quality randomized clinical trials are needed to determine if anti-inflammatory benefits of CBD for heart disease seen in preclinical data will work in a real-world setting, according to research presented at ACC Latin America 2022 Together with CardioAcademic.

5 Sep 2022

Alternative approaches to functional and phenotypic assays using multi-parameter flow cytometry

Synexa is an industry-leading biomarker and large molecule bio analytic research service provider. In this interview, NewsMedical speaks with Natalie Strickland, a principal scientist at Synexa, about alternative approaches to flow cytometry.

From Synexa Life Sciences 5 Sep 2022

Immune cells beyond CAR-T cells affect the durability of response to BCMA CAR T therapy in myeloma

Patients with myeloma whose tumor immune microenvironments had a more diverse baseline T-cell repertoire, fewer markers of immune cell exhaustion, and distinct changes to immune cell populations were more likely to have longer progression-free survival (PFS) after treatment with BCMA-targeted T-cell therapy.

30 Aug 2022

New treatment may be effective in addressing the long-term effects of preeclampsia

Preeclampsia is a condition that affects the placenta during pregnancy and is dangerous for both the fetus and the mother.

30 Aug 2022

Using human tissue models to improve treatment and diagnosis of heart attacks

A heart attack, or myocardial infarction, is one of the leading causes of mortality worldwide, resulting in 18 million deaths per year.

30 Aug 2022

CU professor explores for noninvasive ways to detect vascularized composite allograft rejection

Soldiers and others who receive severe injuries to the hands and face often can benefit from a type of transplant known as vascularized composite allograft (VCA) - the transplantation of multiple tissues, including muscle, bone, nerve, skin, and blood vessels, as a functional unit (such as a hand or face) from a deceased donor to a recipient with a severe injury.

25 Aug 2022

Using the power of CRISPR to engineer better, stronger, longer-lived T cells

T cells used in immunotherapy treatments can get exhausted by the task of fighting cancer cells or get shutdown as they enter tumors.

24 Aug 2022

CRISPR genome-editing technology can be used as a tool to discover RNA therapeutics for lung cancer

An international team of scientists have demonstrated for the first time that CRISPR genome-editing technology can be used as a tool to find new gene therapies for lung cancer.

24 Aug 2022

New preclinical drug candidate shows promise in eradicating gonorrhea bacteria

A new preclinical drug candidate developed by scientists at the Hackensack Meridian Center for Discovery and Innovation (CDI) shows great promise in eradicating the bacteria causing gonorrhea, according to a new publication.

23 Aug 2022

“Drug factory” implants show promise in eradicating mesothelioma tumors

Rice University and Baylor College of Medicine researchers have shown they can eradicate advanced-stage mesothelioma tumors in mice in just a few days with a treatment combining Rice's cytokine "drug factory" implants and a checkpoint inhibitor drug.

22 Aug 2022

Researchers reveal details of two key transition points in the development of pancreatic tumors

Pancreatic cancer has few treatment options and limited survival, with only 9% of patients still living five years after diagnosis.

22 Aug 2022

New anti-cancer drug candidate is absorbed through the lymphatic system rather than blood vessels

A team of University of Michigan researchers is developing a new anti-cancer drug that is absorbed through the gut's lymphatic system rather than blood vessels, potentially outmaneuvering the molecular signaling pathways that lead to drug resistance while increasing cancer-fighting ability and reducing side effects.

17 Aug 2022

Discovery explains how impaired metabolism triggers neuroendocrine tumors in the adrenal glands

Researchers have deciphered a signaling cascade through which inborn errors in metabolism provoke deadly neuroendocrine tumors in the adrenal glands.

16 Aug 2022

Preclinical News and Research

Scientists develop and test a new model of traumatic brain injury in zebrafish

STRATAGEM aims to provide new perspectives on multidrug-resistant solid tumors

Prenatal cannabis exposure linked with mental health problems that persist into early adolescence

Can cod liver oil supplementation prevent COVID-19 and other acute respiratory infections?

Can preclinical COVID-19 models help unlock mystery of long-COVID?

Low-dose ketamine is safe and effective to treat children with ADNP syndrome, study suggests

PhoreMost enters multi-project drug target discovery collaboration with Roche

High-quality human clinical trials needed to determine the benefits of CBD for heart disease patients

Alternative approaches to functional and phenotypic assays using multi-parameter flow cytometry

Immune cells beyond CAR-T cells affect the durability of response to BCMA CAR T therapy in myeloma

New treatment may be effective in addressing the long-term effects of preeclampsia

Using human tissue models to improve treatment and diagnosis of heart attacks

CU professor explores for noninvasive ways to detect vascularized composite allograft rejection

Using the power of CRISPR to engineer better, stronger, longer-lived T cells

CRISPR genome-editing technology can be used as a tool to discover RNA therapeutics for lung cancer

New preclinical drug candidate shows promise in eradicating gonorrhea bacteria

“Drug factory” implants show promise in eradicating mesothelioma tumors

Researchers reveal details of two key transition points in the development of pancreatic tumors

New anti-cancer drug candidate is absorbed through the lymphatic system rather than blood vessels

Discovery explains how impaired metabolism triggers neuroendocrine tumors in the adrenal glands

Event guide: 4th LNP Formulation & Process Development Summit eBook

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