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Researchers develop a cell culture test to detect substances that harm the placenta and embryo

Researchers at ETH Zurich have developed a cell culture test to detect substances that are directly or indirectly harmful to embryos. Based on an existing test used for developing new drugs and chemicals, the augmented version is designed to help reduce the number of animal experiments.

22 Jul 2021

Researchers use information theory to monitor resistance mechanisms to targeted cancer therapy

One of the major challenges in modern cancer therapy is the adaptive response of cancer cells to targeted therapies: initially, these therapies are very often effective, then adaptive resistance occurs, allowing the tumor cells to proliferate again.

21 Jul 2021

New substance derived from Saussurea controversa exhibits osteoprotective properties

Metabolic bone diseases, including osteoporosis, when bones lose their mass and become so fragile that they could be damaged while sneezing or under little stress, are called the silent epidemic of the 21st century.

20 Jul 2021

Potent nasal vaccine protects non-human primates from SARS-CoV-2

A team of US-based scientists has recently demonstrated the efficacy of a live attenuated, recombinant coronavirus disease 2019 (COVID-19) vaccine candidate currently under phase I clinical trial as a single-dose intranasal vaccine.

20 Jul 2021

Next-generation COVID-19 vaccine provides robust immunity against SARS-CoV-2 in mice

Researchers in Canada have developed an adenoviral vector-based vaccine against coronavirus disease 2019 (COVID-19) that induced robust immune protection against the ancestral strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice.

20 Jul 2021

Redhill Biopharma announces completion of Phase 2/3 COVID-19 study of oral opaganib

RedHill Biopharma Ltd., a specialty pharma company that is a leader in the development of novel oral therapies for COVID-19, today announced that all treatment and follow-up has now been completed in the 475-patient global Phase 2/3 study with opaganib (ABC294640) in patients hospitalized with severe COVID-19 pneumonia (NCT04467840). Top-line results are expected in the coming weeks.

20 Jul 2021

Iodine derivative kills SARS-CoV-2 within 90 sec

A recent study estimated the virucidal efficacy of EID for oral/nasal decontamination of known or suspected cases of COVID-19.

19 Jul 2021

Inhibition of SARS-CoV-2 by bentonite-based nasal spray

Therefore, the nose is an important target for prophylaxis and also for therapy. In a recent study posted to the bioRxiv* preprint server, Fabio Fais et al. developed a safe and easy-to-use nasal spray, AM-301, a medical device marketed as Bentrio, to protect against infection by SARS-CoV-2 and potentially other viruses.

19 Jul 2021

Evaluation of a synthetic DNA SARS-CoV-2 vaccine INO-4800 using a nonhuman primate model

A new study published in Vaccine assesses the safety and efficacy of the synthetic DNA vaccine candidate INO-4800, delivered as a single or double dose regime.

18 Jul 2021

A drug candidate to prevent adverse reactions due to COVID-19 infection or vaccines

A new study describes the promising results of a new drug candidate in combating the illness caused by the binding of COVID-19-specific antibodies to infected cells.

18 Jul 2021

Study uncovers how force dynamics affect cells and living tissues

Researchers, led by Pere Roca-Cusachs at the Institute for Bioengineering of Catalonia (IBEC) discover how force dynamics affect cells, and living tissues. The results give an insight into the critical mechanical processes that occur in different diseases such as cancer.

16 Jul 2021

Potential compounds targeting SARS-COV-2 main protease (in vivo)

Now, new research published in the journal Hippokratia focuses on assisting the ongoing COVID-19 therapeutic research by developing a new method to identify active compounds that have the potential to fight against COVID-19 infection.

15 Jul 2021

New OMV-based COVID-19 vaccine candidate proves effective in mice

Researchers in Italy have demonstrated the efficacy of using modified outer membrane vesicles (OMVs) as a vaccine to protect against coronavirus disease 2019 (COVID-19) in an animal model.

14 Jul 2021

Component derived from turmeric essential oil exhibits neuroprotective effects

Researchers from Kumamoto University, Japan have found that a component derived from turmeric essential oil, aromatic turmerone (ar-turmerone), and its derivatives act directly on dopaminergic nerves to create a neuroprotective effect on tissue cultures of a Parkinson's disease model.

14 Jul 2021

Researchers examine efficacy of CT-P59 monoclonal antibody against SARS-CoV-2 Brazil variant

The therapeutic monoclonal antibody CT-P59 binds to the RBD of SARS-CoV-2, the site of these three major mutations, which may therefore reduce the potency of this antibody against the P.1 lineage. In a new study, the neutralizing potency of this monoclonal antibody towards both wildtype and P.1 SARS-CoV-2 is investigated. The researchers found that the ability to bind with the virus is impeded by the mutations, resulting in reduced potency in vitro.

14 Jul 2021

Researchers identify new type of nanoclusters for targeted imaging-guided combined cancer therapy

As a minimally invasive method for cancer therapy at precise locations, NIR-induced photothermal therapy (PTT) has drawn extensively attention. The therapeutic mechanism is the use of photothermal agents (PTAs) in the treatment of tumors,and its therapeutic effect happens only at the tumor site where both light-absorbent and localized laser radiation coexist.

14 Jul 2021

Neutralizing aptamers block SARS-CoV-2 infection in vitro

A new study describes the clinical utility of aptamers against SARS-CoV-2.

13 Jul 2021

Natural compound 'pheophorbide a' demonstrates robust antiviral activity against SARS-CoV-2 in vitro

A team of scientists from France has recently demonstrated photosensitive antiviral activity of the natural compound pheophorbide a (Pba) against a broad range of enveloped viruses, including coronaviruses.

12 Jul 2021

What is behind the inconsistent results of COVID-19 clinical trials?

“Most clinical studies of antiviral drugs for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) have failed to observe a statistically significant effect, which may be due to poor designs of clinical trials.”

12 Jul 2021

Accelerating the design of minibinder therapeutics resilient to SARS-CoV-2 mutations

Multivalent protein-based minibinders hold great promise as potential prophylactic and treatment agents, as they can retain their activity against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern. This was revealed in a recent tour-de-force research study currently available on the bioRxiv* preprint server while the article undergoes the peer review process.

11 Jul 2021

in vivo News and Research

Researchers develop a cell culture test to detect substances that harm the placenta and embryo

Researchers use information theory to monitor resistance mechanisms to targeted cancer therapy

New substance derived from Saussurea controversa exhibits osteoprotective properties

Potent nasal vaccine protects non-human primates from SARS-CoV-2

Next-generation COVID-19 vaccine provides robust immunity against SARS-CoV-2 in mice

Redhill Biopharma announces completion of Phase 2/3 COVID-19 study of oral opaganib

Iodine derivative kills SARS-CoV-2 within 90 sec

Inhibition of SARS-CoV-2 by bentonite-based nasal spray

Evaluation of a synthetic DNA SARS-CoV-2 vaccine INO-4800 using a nonhuman primate model

A drug candidate to prevent adverse reactions due to COVID-19 infection or vaccines

Study uncovers how force dynamics affect cells and living tissues

Potential compounds targeting SARS-COV-2 main protease (in vivo)

New OMV-based COVID-19 vaccine candidate proves effective in mice

Component derived from turmeric essential oil exhibits neuroprotective effects

Researchers examine efficacy of CT-P59 monoclonal antibody against SARS-CoV-2 Brazil variant

Researchers identify new type of nanoclusters for targeted imaging-guided combined cancer therapy

Neutralizing aptamers block SARS-CoV-2 infection in vitro

Natural compound 'pheophorbide a' demonstrates robust antiviral activity against SARS-CoV-2 in vitro

What is behind the inconsistent results of COVID-19 clinical trials?

Accelerating the design of minibinder therapeutics resilient to SARS-CoV-2 mutations

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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