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The brain’s hunger switch: TRH neurons hold the key to obesity therapies

Scientists uncover how TRH neurons suppress hunger by inhibiting AgRP neurons, advancing our understanding of GLP-1-based obesity treatments.

9 Dec 2024

Lab-grown tumor organoids predict patient response to CAR T cell therapy

For the first time, researchers used lab-grown organoids created from tumors of individuals with glioblastoma (GBM) to accurately model a patient's response to CAR T cell therapy in real time.

9 Dec 2024

Two new subtypes of MASH revealed with different risks and outcomes

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly referred to as nonalcoholic fatty liver disease (NAFLD), impacts roughly 30% of the global adult population.

9 Dec 2024

Antibody trials show encouraging results in patients with high-risk forms of two blood cancers

Two clinical trials testing the antibody loncastuximab tesirine (Zynlonta) showed encouraging results in patients with high-risk forms of two blood cancers – follicular lymphoma and marginal zone lymphoma.

9 Dec 2024

Pioneering study discovers new genetic links to pancreatic cancer in Brazil

Pancreatic cancer has recently been included in the list of diseases about which Brazil's National Cancer Institute (INCA) periodically publishes statistics.

9 Dec 2024

Can HIIT's metabolic benefits last? New study explores post-exercise sustainability in diabetes

Researchers investigate whether high-intensity interval training-induced metabolic benefits sustain or differ after prolonged training cessation.

9 Dec 2024

Newcells Biotech raises additional funding from investors

Newcells Biotech (“Newcells”), a leading drug discovery partner specializing in the development of in vitro models and bespoke assay services to improve the prediction of in vivo human outcomes, today announced it has raised a further £1.2 m from existing investors Mercia Ventures, Northstar Ventures and North East Finance.

From Newcells Biotech 8 Dec 2024

Study reveals how DNA folding drives gene activity bursts

Researchers at Kyushu University have revealed how spatial distance between specific regions of DNA is linked to bursts of gene activity.

6 Dec 2024

MRI study offers new insights into celiac disease treatment

Experts have used magnetic resonance imaging (MRI) to better understand the impact a gluten free diet has on people with coeliac disease, which could be the first step towards finding new ways of treating the condition.

6 Dec 2024

New insights into the mechanisms of "Niemann-Pick type C" in children

In the journal "Science Translational Medicine", scientists from DZNE and LMU Hospital report on new insights into the mechanisms of "Niemann-Pick type C" (NPC), a rare neurodegenerative disease associated with dementia that can manifest as early as childhood.

6 Dec 2024

MRI-based imaging technique predicts the response of ovarian cancer to treatment

An MRI-based imaging technique developed at the University of Cambridge predicts the response of ovarian cancer tumors to treatment, and rapidly reveals how well treatment is working, in patient-derived cell models.

6 Dec 2024

New AI method enhances breast cancer risk prediction from mammograms

A new study from Washington University School of Medicine in St. Louis describes an innovative method of analyzing mammograms that significantly improves the accuracy of predicting the risk of breast cancer development over the following five years.

6 Dec 2024

Reimagining axons with the pearls-on-a-string model

In a provocative new study, scientists challenge a fundamental tenet in neuroscience about the shape of axons -- the long, thin filaments radiating from nerve cells that transmit electrical signals from cell to cell – and propose a new model for understanding how information is transmitted in the brain.

6 Dec 2024

Study: Brain volume changes correlate with social behavior differences in psychiatric conditions

A study published in Molecular Psychiatry found that brain volume changes correlate with social behavior differences in psychiatric conditions such as autism spectrum disorder and schizophrenia.

6 Dec 2024

Researchers map neural pathways involved in response inhibition

In the split second that is needed to view a stop sign and react to it, our brain navigates a complex process that transitions seamlessly from perception to action control.

6 Dec 2024

AI-enhanced mammography improves cancer detection in self-pay program

More than a third of women across 10 health care practices chose to enroll in a self-pay, artificial intelligence (AI)-enhanced breast cancer screening program, and the women who enrolled were 21% more likely to have cancer detected, according to research being presented today at the annual meeting of the Radiological Society of North America (RSNA).

6 Dec 2024

Genomic conservation in Thailand's mangroves

In this interview, Wirulda Pootakham, the Director of Thailand's National Omic Centre, talks to NewsMedical about genomic conservation in Thailand's mangroves.

From MGI 6 Dec 2024

AI predicts mortality with whole-body MRI for personalized health insights

Researchers developed a deep learning framework for whole-body MRI-based body composition analysis, predicting mortality more accurately than traditional methods. This innovative approach could revolutionize personalized risk assessments and clinical workflows.

5 Dec 2024

Phase one trial explores novel immunotherapy for breast cancer

A groundbreaking phase one clinical trial exploring a novel cell-based immunotherapy for breast cancer has been accepted for publication in JAMA Oncology.

5 Dec 2024

New risk score accurately predicts cardiovascular events in women

A new risk score accurately predicts and categorizes the risk of major adverse cardiovascular events, such as heart attack, in women. The findings were published today in Radiology: Cardiothoracic Imaging, a journal of the Radiological Society of North America (RSNA).

5 Dec 2024