Preclinical News and Research

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The effects of CBD in the treatment of COVID-19–related inflammatory symptoms

Researchers reviewed the effectiveness of cannabidiol in treating COVID-19 inflammatory-related symptoms.

28 Jul 2022

Investigating an effective linear deoxyribonucleic acid COVID-19 vaccine option for domestic cats

In a new study, investigators studied a linear deoxyribonucleic acid (linDNA) SARS-CoV-2 vaccine option in felines.

27 Jul 2022

Study shows the emerging Omicron sublineage BA.2.75 does not show greater immune evasion than BA.5

Researchers assessed the sensitivity of SARS-CoV-2 Omicron BA.2.75 variant to neutralizing antibodies.

27 Jul 2022

Study confirms link between Epstein-Barr virus and multiple sclerosis

Researchers investigate the association between Epstein-Barr virus infection and multiple sclerosis.

26 Jul 2022

IU researchers evaluate the efficacy of a failed clinical trial drug for Alzheimer's using rigorous pipeline

Most drugs developed to treat Alzheimer's disease have for years been ineffective in clinical trials. Researchers from Indiana University School of Medicine recently evaluated the efficacy of a failed clinical trial drug using their rigorous pipeline.

25 Jul 2022

Research reveals molecular clues associated with traumatic brain injury

New research led by scientists at Arizona State University has revealed some of the first detailed molecular clues associated with one of the leading causes of death and disability, a condition known as traumatic brain injury (TBI).

23 Jul 2022

Two UTHSC research teams receive CORNET Awards for novel projects

Two research teams at the University of Tennessee Health Science Center (UTHSC) have been awarded the 2022 UTHSC Collaborative Research Network (CORNET)-Functional Genomics Award. Each team will receive $50,000 to support their novel projects.

22 Jul 2022

Oligomeric molecular structure of the MOR-Gal1R complex revealed

A study published in the journal Pharmacological Research reveals the oligomeric molecular structure of the MOR-Gal1R complex, a component present in the brain which is involved in the analgesic and addictive effects of certain opioids.

22 Jul 2022

New study to investigate focused ultrasound's role in addressing neurofibromatosis type 2

The Focused Ultrasound Foundation and the Children's Tumor Foundation (CTF) have established a partnership to advance innovative, noninvasive treatments in pediatrics.

21 Jul 2022

FDA clears IND application for MD Anderson-sponsored Phase I clinical study of OBX-115 therapy

The University of Texas MD Anderson Cancer Center and Obsidian Therapeutics, Inc. today announced Food and Drug Administration (FDA) clearance of an Investigational New Drug (IND) application for an MD Anderson-sponsored Phase I clinical study of OBX-115, Obsidian's lead engineered tumor infiltrating lymphocyte (TIL) therapy candidate.

21 Jul 2022

Antibiotics have sex-specific effects on the gut microbiome, preclinical study finds

In a new study, researchers at Cedars-Sinai found that antibiotics have sex-specific effects on the gut microbiome makeup of male and female laboratory rats. The findings, published in the journal Frontiers in Microbiology, could have implications for using the drugs in humans to treat or prevent bacterial infection.

20 Jul 2022

Study finds white adipose tissue to be the most vulnerable organ to obesity-related metabolic changes

When the body is subjected to a high-calorie diet, the physiological response is not homogeneous and some organs or tissues are more sensitive to metabolic stress.

20 Jul 2022

Omicron-specific mRNA vaccine provides superior immune protection against two viral subvariants

Yale scientists have developed a novel Omicron-specific mRNA vaccine that offers superior immune protection against two viral subvariants than standard mRNA vaccines.

20 Jul 2022

Study determines the reason behind the failure of IVF embryos

In humans, a fertilized egg is no guarantee of reproductive success. Most embryos stop developing and perish within days of fertilization, usually because they have an abnormal number of chromosomes. Now, researchers at Columbia University Vagelos College of Physicians and Surgeons have found that most of these mistakes are due to spontaneous errors in DNA replication in the earliest phase of cell division.

20 Jul 2022

Study offers new insights into brain metastases in patients with melanoma

Brain metastasis is one of the most common causes of cancer-related deaths and occurs very frequently in patients with advanced melanoma.

18 Jul 2022

Chemokine-DNA nanoparticles can induce chronic, dysfunctional immune responses

Small proteins, called chemokines, that direct immune cells toward sites of infection can also form DNA-bound nanoparticles that can induce chronic, dysfunctional immune responses, according to a new study by researchers at Weill Cornell Medicine and Hospital for Special Surgery (HSS).

15 Jul 2022

Researchers discover specific cells that regulate the transmission of information between brain areas

A scientific team from MedUni Vienna's Center for Brain Research has now identified specific cells that regulate the transmission of information between brain areas.

15 Jul 2022

New mouse model faithfully mimics brain damage caused by severe Rift Valley Fever virus infection

A new mouse model identified by virologists from the University of Pittsburgh might revolutionize development of therapies targeting brain inflammation caused by Rift Valley Fever virus (RVFV).

15 Jul 2022

Age-related increases in brain inflammation may link Alzheimer's disease risk with sleep disturbance

A multisite research team from the University of California, Irvine, the University of Wisconsin–Madison and Wake Forest University has discovered that brain inflammation may link Alzheimer's disease risk with sleep disturbance, which may aid early detection and prevention efforts by identifying novel treatment targets at preclinical stages.

13 Jul 2022

Activation of the STING pathway could help make glioblastoma multiforme more susceptible to immunotherapy

Immunotherapy has revolutionized treatment for many forms of cancer, but glioblastoma multiforme (GBM), the most common and deadly form of brain cancer, has remained untouched.

11 Jul 2022

Preclinical News and Research

The effects of CBD in the treatment of COVID-19–related inflammatory symptoms

Investigating an effective linear deoxyribonucleic acid COVID-19 vaccine option for domestic cats

Study shows the emerging Omicron sublineage BA.2.75 does not show greater immune evasion than BA.5

Study confirms link between Epstein-Barr virus and multiple sclerosis

IU researchers evaluate the efficacy of a failed clinical trial drug for Alzheimer's using rigorous pipeline

Research reveals molecular clues associated with traumatic brain injury

Two UTHSC research teams receive CORNET Awards for novel projects

Oligomeric molecular structure of the MOR-Gal1R complex revealed

New study to investigate focused ultrasound's role in addressing neurofibromatosis type 2

FDA clears IND application for MD Anderson-sponsored Phase I clinical study of OBX-115 therapy

Antibiotics have sex-specific effects on the gut microbiome, preclinical study finds

Study finds white adipose tissue to be the most vulnerable organ to obesity-related metabolic changes

Omicron-specific mRNA vaccine provides superior immune protection against two viral subvariants

Study determines the reason behind the failure of IVF embryos

Study offers new insights into brain metastases in patients with melanoma

Chemokine-DNA nanoparticles can induce chronic, dysfunctional immune responses

Researchers discover specific cells that regulate the transmission of information between brain areas

New mouse model faithfully mimics brain damage caused by severe Rift Valley Fever virus infection

Age-related increases in brain inflammation may link Alzheimer's disease risk with sleep disturbance

Activation of the STING pathway could help make glioblastoma multiforme more susceptible to immunotherapy

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