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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

New data analysis method accelerates design of safer covalent inhibitors

Researchers at Baylor College of Medicine have developed a powerful new data analysis method named COOKIE-Pro (Covalent Occupancy Kinetic Enrichment via Proteomics) that provides a comprehensive, unbiased view of how a class of drugs, called covalent inhibitors, interacts with proteins throughout the cell.

30 Sep 2025

Inflammation at the heart’s core: What clinicians and families can do now

Chronic low-grade inflammation is a key driver of cardiovascular disease, even when cholesterol is controlled. The ACC’s 2025 Scientific Statement highlights hsCRP as a routine risk marker and outlines lifestyle and pharmacologic anti-inflammatory strategies for prevention and treatment.

30 Sep 2025

Categorizing the risk factors for portal vein thrombosis in liver cirrhosis

Portal vein thrombosis (PVT) is a critical complication in liver cirrhosis (LC), significantly worsening portal hypertension and accelerating the progression to decompensation.

30 Sep 2025

Discovery of EUDAL reveals new mechanism behind chemotherapy resistance in oral cancer

Oral cancer is one of the most common head and neck cancers worldwide, with hundreds of thousands of new cases diagnosed every year. Despite advances in surgery, radiotherapy, and chemotherapy, survival rates remain poor.

30 Sep 2025

Study assesses the efficacy of protein hydrolysis in developing gut-friendly dairy alternatives

A recent Finnish study investigated the effects of A2 milk, marketed as a gut-friendly alternative, and protein-hydrolyzed lactose-free milk on gastrointestinal symptoms and inflammation levels. The study found that protein-hydrolyzed lactose-free milk was as tolerated as A2 milk by lactose-tolerant individuals and better tolerated by lactose-intolerant individuals.

30 Sep 2025

Researchers design factor IX variants for short- and long-term Hemophilia B management

After blood vessel damage, effective blood clotting is essential to halt bleeding. However, this process is inefficient in some individuals due to hereditary factors. Hemophilia B, for example, results from a deficiency in coagulation factor IX (FIX), which can lead to prolonged bleeding after injuries or surgery.

30 Sep 2025

Scientists test whether chaya leaves can lower blood sugar in diabetes

Researchers reviewed current evidence on the chaya plant (Cnidoscolus chayamansa), highlighting its nutritional profile, hypoglycemic activity in animal models, and potential as a complementary aid for diabetes management. While promising, safety, dosage, and interaction studies remain essential before clinical use.

29 Sep 2025

Small molecule AVJ16 shows promise in targeting lung cancer growth

Researchers have discovered a promising new approach to lung cancer treatment. A small molecule called AVJ16 selectively blocks the cancer-driving protein IGF2BP1, halting tumor growth in preclinical studies and killing cancer cells in patient-derived models—while leaving healthy cells unharmed.

29 Sep 2025

How maternal microbes shape babies’ gut health and disease risk

Early microbial exposures from maternal microbes, milk components, and the environment shape infant gut development and long-term disease risk. The review highlights mechanisms, preventive levers, and research gaps in supporting healthy microbiome inheritance across generations.

29 Sep 2025

Cannabidiol shows promise for obesity and metabolic syndrome

Cannabidiol (CBD) shows promise in regulating appetite, glucose and lipid metabolism, and inflammation in preclinical models of obesity and metabolic syndrome. However, human evidence is still limited, highlighting the need for rigorous trials before clinical use.

29 Sep 2025

New ACC Scientific Statement highlights inflammation in cardiovascular disease

The American College of Cardiology (ACC) released today its second Scientific Statement, Inflammation and Cardiovascular Disease (CVD).

29 Sep 2025

Study points toward earlier and more accurate detection of ALS

A new study applying multi-omics techniques and machine learning identified 33 plasma proteins that differ significantly in patients with amyotrophic lateral sclerosis (ALS).

29 Sep 2025

Combining radiopharmaceuticals with targeted radiation improves progression-free survival in prostate cancer patients

A new clinical trial finds that people with a limited number of metastases from recurrent prostate cancer lived significantly longer without disease progression when they received a radiopharmaceutical drug before targeted radiation, compared with radiation alone.

29 Sep 2025

Many older adults meet criteria for ultra-processed food addiction

They were the first generation of Americans to grow up with ultra-processed foods all around them – products typically loaded with extra fat, salt, sugar and flavorings.

29 Sep 2025

Cancer cell nuclear hypertrophy can suppress metastasis

In tissue biopsies, cancer cells are frequently observed to have nuclei (the cell's genetic information storage) larger than normal.

29 Sep 2025

Plant-based dog food cuts environmental impact by over 90% vs. red meat

Comparative research highlights the environmental benefits of plant-based dog food, showing reduced land use and emissions versus traditional meat-based diets.

29 Sep 2025

RSV vaccines protect two most-at-risk groups from severe illness

The review demonstrates that vaccines for respiratory syncytial virus (RSV) are both safe and effective in protecting groups who are most at risk for serious illness, including older adults and infants.

29 Sep 2025

Super-resolution imaging unlocks the role of transporter nanoclusters in tumor metabolism

Serine serves as a metabolic nexus in tumors, coordinating one-carbon metabolism, nucleotide synthesis, and redox regulation. In recent years, targeting the serine metabolic pathway, particularly the rate-limiting enzyme PHGDH, has attracted considerable attention as a promising anticancer strategy.

29 Sep 2025