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Antagonism of glucocorticoid receptors promotes apoptosis in solid tumor cells

Oncotarget published "Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells" which reported that to guide studies in cancer patients, relacorilant, an investigational selective GR modulator that antagonizes cortisol activity, was assessed in various tumor types, with multiple cytotoxic combination partners, and in the presence of physiological cortisol concentrations.

28 Jun 2021

New technology can help improve various materials implanted into the human body

Medical materials that can be inserted into the human body have been used for decades in the field of regenerative medicine - for example, stents that can help dilate clogged blood vessels and implants that can replace teeth or bones.

25 Jun 2021

Study: Low Omega-3 Index is just as powerful in predicting early death as smoking

A new research paper published in the American Journal of Clinical Nutrition last week showed that a low Omega-3 Index is just as powerful in predicting early death as smoking. This landmark finding is rooted in data pulled and analyzed from the Framingham study, one of the longest running studies in the world.

25 Jun 2021

Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis

In a new study published in Circulation Research, Chen-Yu Zhang and Xiaohong Jiang's group from Nanjing University and Dongjin Wang's group from Nanjing Drum Tower Hospital reported a critical role of PGC1α in maintaining the contractile phenotype of vascular smooth muscle cells (VSMCs) and highlighted the therapeutic potential of PGC1α for atherosclerosis.

25 Jun 2021

Researchers uncover new function of regulator protein in multiple myeloma development

A specific regulatory protein significantly influences the development of tumor-inducing blood vessels in the bone marrow of blood cancer patients.

24 Jun 2021

Study finds no evidence for remdesivir's benefit in severe COVID-19 patients

A new analysis of current data indicates that remdesivir does not show efficacy in regulating the severity of the illness.

23 Jun 2021

New coatings for titanium implants can fasten osseointegration

Researchers from Peter the Great St.Petersburg Polytechnic University (SPbPU) in collaboration with colleagues from St. Petersburg State University developed the coatings for titanium implants, which accelerate the implantation of the implant material into the bone tissue.

23 Jun 2021

Increasing novel lncRNA in cardiomyocytes can inhibit the progression of heart failure

A research collaboration based in Kumamoto University (Japan) has identified a novel lncRNA, Caren, that is abundantly expressed in cardiomyocytes.

23 Jun 2021

Protein found in cow’s milk could increase absorption of blueberries’ nutrients

Pairing blueberry pie with a scoop of ice cream is a nice summer treat. Aside from being tasty, this combination might also help people take up more of the "superfruit's" nutrients, such as anthocyanins.

23 Jun 2021

$New composite material could soon replace metal plates in treating difficult fractures$

New composite material could soon replace metal plates in treating difficult fractures

A new biocompatible polymer-based composite material could soon replace metal plates in treating difficult and unstable fractures.

23 Jun 2021

Natural compound myricetin shows antiviral potential against SARS-CoV-2

New findings from a team of Chinese researchers suggest natural compounds — specifically the flavonoid myricetin — could also be a potential drug candidate for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

23 Jun 2021

Albumin supplementation improves human fertility, fights infection

A new University of California, Irvine-led study reveals albumin (Alb), among the most abundant proteins in the body, activates a proton channel (hHv1), also widespread in the body, giving sperm the ability to penetrate and fertilize an egg, and allowing white blood cells to secrete large amounts of inflammatory mediators to fight infection.

22 Jun 2021

Researchers decode the mechanisms of cell renewal process

The human intestine is made up of more than 40 square meters of tissue, with a multitude of folds on its internal surface that resemble valleys and mountain peaks in order to increase the absorption of nutrients.

22 Jun 2021

RedHill presents positive Phase 2 results for oral opaganib in patients with COVID-19 pneumonia

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced presentation of the positive Phase 2 safety and efficacy data for oral opaganib (Yeliva®, ABC294640) in hospitalized patients with COVID-19 pneumonia at the World Microbe Forum (WMF) 2021 (poster #: 5574).

21 Jun 2021

FLASH radiotherapy could revolutionize future tumor treatments

It could become a breakthrough for future tumor treatments with heavy ions and pave new ways: In the current experiment period FAIR-Phase 0, the GSI Helmholtzzentrum für Schwerionenforschung and the future accelerator center FAIR succeeded in performing a carbon ion FLASH experiment for the first time.

21 Jun 2021