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New $400 million donation reinforces Columbia's leadership in biomedical science

Columbia University announced today a new $400 million gift from Roy and Diana Vagelos, which will secure Columbia's leadership in biomedical science research and education and produce a vast array of compelling opportunities for improving society's health and wellbeing.

22 Aug 2024

New insights into macrophages' role in MASH and liver fibrosis

Formerly known as nonalcoholic steatohepatitis, metabolic dysfunction-associated steatohepatitis (MASH) is an inflammatory disease characterized by liver scarring or fibrosis that progressively impairs liver function.

22 Aug 2024

Asgard archaea's role in eukaryotic immunity revealed

When you get infected with a virus, some of the first weapons your body deploys to fight it were passed down to us from our microbial ancestors billions of years ago.

22 Aug 2024

Responding to Mpox: Global outbreak, research innovations, and therapeutic strategies

In August 2024, the WHO declared Mpox (formerly known as Monkeypox) a global health emergency due to rising Clade I Mpox cases in Africa and Sweden, highlighting the urgency for coordinated global efforts to monitor and mitigate the spread of the virus.

From Sino Biological Inc. 22 Aug 2024

The surprising role of RNA in immune interactions

In a groundbreaking exploration of cell surface biology, Ryan Flynn has uncovered a surprising role for RNA outside the confines of the cell. Flynn's research, which focuses on the biology of cell surface RNA, led to the discovery that certain RNAs are chemically linked to glycans - complex carbohydrate polymers found on the cell surface.

22 Aug 2024

Understanding gluten's role in autoimmunity and inflammation

The interaction between humans and their environment, mediated by nutrition, plays a crucial role in regulating inflammatory responses.

21 Aug 2024

Spatial transcriptomics unlocks malaria's liver stage secrets

For the malaria parasite to reach the blood of its human host, it must first enter the liver, where only a small number of parasites differentiate and replicate for upwards of seven days, making it a bottleneck in the parasite's lifecycle. This bottleneck makes the liver stage an optimal target for effective and long-lasting vaccines against the disease. Using Spatial Transcriptomics and single-cell RNA-sequencing technologies, researchers at Stockholm University have for the first time managed to create a spatio-temporal map of malaria infection in the mouse liver. A study that was recently published in Nature Communications.

21 Aug 2024

UQ research could lead to a more effective treatment for bladder cancer

University of Queensland research could lead to a more effective immunotherapy treatment against bladder cancer.

20 Aug 2024

Engineered heart tissues uncover new mechanisms in lupus-related heart damage

Cardiovascular disease is the leading cause of death in patients suffering from lupus, an autoimmune disease in which our immune system attacks our own tissues and organs, the heart, blood, lung, joints, brain, and skin.

20 Aug 2024

UC Davis researchers unveil pathway for Salmonella's gut invasion

How do bad bacteria find entry points in the body to cause infection? This question is fundamental for infectious disease experts and people who study bacteria.

20 Aug 2024

New genomic technique tracks superbugs in hospitals for faster infection management

Researchers have developed a new genomic technique that can track the spread of multiple superbugs in a hospital simultaneously, which could help prevent and manage common hospital infections quicker and more effectively than ever before.

20 Aug 2024

Advances in precision medicine enhance cancer immunotherapy

The field of precision medicine, especially in the context of cancer immunotherapy, has seen significant advancements in recent years.

20 Aug 2024

Study links gut microbe depletion to lifelong respiratory allergies

Researchers at the University of British Columbia have shown for the first time how and why the depletion of microbes in a newborn's gut by antibiotics can lead to lifelong respiratory allergies.

20 Aug 2024

New project aims to study the combination of two therapies for pediatric brain cancer

Natasha Sheybani, assistant professor of biomedical engineering at the University of Virginia School of Engineering, will collaborate with researchers at Children's National Hospital to study the combination of two therapies for pediatric brain cancer.

19 Aug 2024

Advancements in neoantigen vaccines offer hope for personalized cancer therapy

The saga of cancer treatment is marked by a relentless pursuit of effectiveness against a disease characterized by complexity and adaptability.

19 Aug 2024

New study reveals overlap between metabolic and immune disorders

Inherited diseases of metabolism and immunity have more in common than previously recognized, according to a new study published in the journal Science Immunology.

16 Aug 2024

New exosome-based drug delivery system enhances ovarian cancer treatment

Ovarian cancer is one of the most common malignancies in women worldwide. Unlike breast cancer, ovarian cancer lacks early diagnostic markers and does not show noticeable symptoms until cancer metastases, leading to a low survival rate for ovarian cancer patients.

16 Aug 2024

Neoadjuvant immunotherapy yields comparable outcomes in high-risk liver cancer surgery

Patients with liver cancer who received immune checkpoint inhibitors (ICIs) before surgery - including those who would not have been eligible for surgery by conventional criteria - had similar outcomes to patients who received surgery upfront, according to results from a retrospective study.

15 Aug 2024

Engineering extracellular vesicles for potential treatment of type 1 diabetes

Within each of us lies an army of cells whose topmost duty is protecting against external pathogens and internal threats such as proliferating cancer cells.

14 Aug 2024

Midlife and early senior years marked by dramatic molecular shifts

If it's ever felt like everything in your body is breaking down at once, that might not be your imagination. A new Stanford Medicine study shows that many of our molecules and microorganisms dramatically rise or fall in number during our 40s and 60s.

14 Aug 2024