Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Bruker launches innovative iProbe HRMAS for biomolecular, materials and clinical research

At EUROMAR 2018 conference (www.euromar2018.org), Bruker announced the iProbe HRMAS, which now enables full automation of high-resolution magic angle spinning NMR.

From Bruker BioSpin Group 10 Jul 2018

Machine-learning model automates design of new molecules to accelerate drug development

Designing new molecules for pharmaceuticals is primarily a manual, time-consuming process that's prone to error. But MIT researchers have now taken a step toward fully automating the design process, which could drastically speed things up -- and produce better results.

9 Jul 2018

Single-cell RNA sequencing reveals how complex brain circuit works

The complexity of the human brain presents scientists with immense challenges as they try to find new treatments for a host of diseases and conditions. But the advent of a new technology known as single-cell RNA sequencing is opening a window into how the brain works.

6 Jul 2018

Lonza launches new website to support bioresearch, drug discovery scientists

Lonza Bioscience is inviting visitors to explore its new dedicated website: bioscience.lonza.com. Filled with detailed application and product information, the website has been designed to support the work of scientists across the bioresearch, drug discovery and pharmaceutical manufacturing fields.

From Lonza 3 Jul 2018

Study finds that several existing anti-cancer drugs may work in part by binding to RNA

Bolstering the notion that RNA should be considered an important drug-discovery target, scientists at Scripps Research have found that several existing, FDA-approved anti-cancer drugs may work, in part, by binding tightly to RNA, the regulators of the basic activities of life within cells.

30 Jun 2018

Bruker introduces innovative Sierra SPR-32 system at European SLAS 2018 meeting

At the European SLAS 2018 meeting, Bruker today announced the launch of its new SierraTM SPR-32 system with even higher sensitivity and new instrument control software to enable highest SPR throughput with outstanding sensitivity.

From Bruker Daltonics 29 Jun 2018

Researchers reveal complexity of NMDA receptor drug discovery target

Know your target. Especially if your target is coming into focus for treating diseases such as schizophrenia and treatment-resistant depression.

28 Jun 2018

Achieving the WHO’s Global Action Plan for Dementia

One year on from the WHO's Global Action Plan for Dementia, Dr. Matthew Norton from Alzheimer's Research UK discusses the steps that have been taken so far, and whether we are likely to meet the 2025 target.

28 Jun 2018

LUMICKS partners with AstraZeneca, University of Cambridge to establish new 'Center of Excellence for Dynamic Single-Molecule Analysis for Accelerated Drug Discovery and Biology'

The center will be based around LUMICKS’ C-Trap™ optical tweezers–fluorescence microscope, which for the first time enables real-time observation and probing of biomolecular interactions. The approach will be pioneered in several pharmacology and biology assays with the aim of accelerating the discovery of potential new drugs.

From Lumicks 28 Jun 2018

UPMC and Pitt announce launch of advanced genome sequencing center

UPMC and the University of Pittsburgh today announced the launch of an advanced genome sequencing center to support clinical diagnostics and research initiatives in precision medicine and immunotherapy.

27 Jun 2018

WashU engineer working to build a more precise microscope

Like our eyes, microscopes are limited in what they can see because of their resolution, or their ability to see detail. The detail, or information, from the object is there, but some of it gets lost as the light reflecting off of the object moves through the air.

26 Jun 2018

AbbVie and Calibr collaborate to develop T-cell therapies aimed at cancer

AbbVie , a research-based global biopharmaceutical company, and Calibr, a nonprofit drug discovery division of Scripps Research, today announced a collaboration to develop T-cell therapies aimed primarily at cancer, including solid tumors.

25 Jun 2018

Researchers discover drug compound that inhibits movement of cancer cells

Fighting cancer means killing cancer cells. However, oncologists know that it's also important to halt the movement of cancer cells before they spread throughout the body.

22 Jun 2018

Study provides clues to how cancer cells develop resistance to chemotherapies

About half of all drugs, ranging from morphine to penicillin, come from compounds that are from - or have been derived from - nature. This includes many cancer drugs, which are toxic enough to kill cancer cells.

22 Jun 2018

Protein Data Bank at Rutgers impacts research, education and drug discovery

When Jimmy Carter was diagnosed with end-stage metastatic melanoma in 2015, he began taking a drug developed in part using 3D molecular data.

21 Jun 2018

Researchers use droplet-sized 'miniecosystems' to test therapeutic potential of molecules

Scripps Research scientists have solved a major problem in chemistry and drug development by using droplet-sized 'miniecosystems' to quickly see if a molecule can function as a potential therapeutic.

19 Jun 2018

Scientists could build better drugs by learning from bacteria-derived molecules

Bacteria found in soil may harbor a potential game-changer for drug design. A new study by Scripps Research, published today in Nature Communications, suggests scientists could build better drugs by learning from bacteria-derived molecules called thiocarboxylic acids.

19 Jun 2018

Novel compound as effective as FDA-approved antibiotics for treating deadly infections

Purdue University researchers have identified a new compound that in preliminary testing has shown itself to be as effective as antibiotics approved by the Food and Drug Administration to treat life-threatening infections while also appearing to be less susceptible to bacterial resistance.

18 Jun 2018

UC San Diego establishes new Center For Anti-Parasitic Drug Discovery And Development

Neglected tropical diseases are a group of chronic and disabling parasitic infections that primarily affect poor and underserved communities.

14 Jun 2018

Unique project to develop fully-automated technology for faster and effective drug discovery

A unique project to develop technology to drive fast and effective drug discovery was announced today by Business Secretary Greg Clark. Based at the Rosalind Franklin Institute in Harwell, Oxfordshire, this new project will pioneer fully-automated hands-free molecular discovery to produce new drugs up to ten times faster and transform the UK’s pharmaceutical industry.

13 Jun 2018

Drug Discovery News and Research

Further Reading

Bruker launches innovative iProbe HRMAS for biomolecular, materials and clinical research

Machine-learning model automates design of new molecules to accelerate drug development

Single-cell RNA sequencing reveals how complex brain circuit works

Lonza launches new website to support bioresearch, drug discovery scientists

Study finds that several existing anti-cancer drugs may work in part by binding to RNA

Bruker introduces innovative Sierra SPR-32 system at European SLAS 2018 meeting

Researchers reveal complexity of NMDA receptor drug discovery target

Achieving the WHO’s Global Action Plan for Dementia

LUMICKS partners with AstraZeneca, University of Cambridge to establish new 'Center of Excellence for Dynamic Single-Molecule Analysis for Accelerated Drug Discovery and Biology'

UPMC and Pitt announce launch of advanced genome sequencing center

WashU engineer working to build a more precise microscope

AbbVie and Calibr collaborate to develop T-cell therapies aimed at cancer

Researchers discover drug compound that inhibits movement of cancer cells

Study provides clues to how cancer cells develop resistance to chemotherapies

Protein Data Bank at Rutgers impacts research, education and drug discovery

Researchers use droplet-sized 'miniecosystems' to test therapeutic potential of molecules

Scientists could build better drugs by learning from bacteria-derived molecules

Novel compound as effective as FDA-approved antibiotics for treating deadly infections

UC San Diego establishes new Center For Anti-Parasitic Drug Discovery And Development

Unique project to develop fully-automated technology for faster and effective drug discovery

Enabling smarter drug development with radiolabeled chemistry and metabolism expertise eBook

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