Therapy News and Research

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PGD model could provide policy guideposts for human genome editing

Human genome editing for both research and therapy is progressing, raising ethical questions among scientists around the world.

22 Jan 2016

Study throws light on why gout not well managed in many patients

A study published online this month in the Arthritis Care and Research journal is shedding light on why gout, a painful and common form of arthritis, is not well managed in many patients. The journal is published by the American College of Rheumatology.

22 Jan 2016

Researchers use ASC secreted factors to create therapeutic factor concentrate for critical limb ischemia

"Critical limb ischemia" (CLI) describes an advanced stage of peripheral artery disease characterized by obstruction of the arteries and a markedly reduced blood flow to the extremities. CLI identifies patients at high-risk for major amputation. The estimated annual incidence of CLI ranges between 500 and 1000 new cases out of one million people per year, with the highest rates among the elderly, smokers, and those with diabetes. CLI is considered to be a critical public health issue. Attempts at revascularization are often unsuccessful.

22 Jan 2016

Oral drug ivacaftor appears to be safe, beneficial to pre-school children with specific type of cystic fibrosis

The oral drug ivacaftor appears to be safe and could be beneficial to young children between the ages of 2 and 5 with a specific type of cystic fibrosis, according to new research published in The Lancet Respiratory Medicine journal.

22 Jan 2016

Amgen announces approval of cholesterol-lowering medication Repatha (evolocumab) Injection in Japan

Amgen today announced that the Japanese Ministry of Health, Labour and Welfare has approved the cholesterol-lowering medication Repatha (evolocumab) Injection, the first proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor to be approved in Japan.

22 Jan 2016

People suffering from chronic stress, anxiety may be at increased risk for depression and dementia

A scientific review paper warns that people need to find ways to reduce chronic stress and anxiety in their lives or they may be at increased risk for developing depression and even dementia.

22 Jan 2016

Champions Oncology begins prospective correlative trial of PDX in patients with sarcoma

Champions Oncology today announced that it has initiated a sponsored prospective correlative trial of patient derived xenograft modeling (PDX or Champions TumorGraft PDX models) in patients with metastatic or recurrent sarcoma. Mount Sinai Hospital in Toronto, Canada is the first clinical site to enroll patients in the newly-opened study.

21 Jan 2016

FDA approves Allergan's sNDA to update label for DALVANCE (dalbavancin) for injection

Allergan plc, a leading global pharmaceutical company, today announced the U.S. Food and Drug Administration has approved the company's supplemental new drug application (sNDA) to update the label for DALVANCE (dalbavancin) for injection.

21 Jan 2016

Allergan announces publication of VIBERZI Phase III trial results in The New England Journal of Medicine

Allergan plc announced today the publication of the positive results of the Phase III trials of VIBERZITM C IV (eluxadoline) for the treatment of irritable bowel syndrome with diarrhea (IBS-D) in the January 21 issue of The New England Journal of Medicine.

21 Jan 2016

Psychological techniques help reduce body dissatisfaction in women with bulimia nervosa

Researchers from the University of Granada have proven that there are two psychological techniques that help reducing body dissatisfaction and its associated symptoms in women with bulimia nervosa, both of them based in the exposure of their bodies in a mirror.

21 Jan 2016

Childhood abuse and neglect associated with worse executive function in adulthood

The scars of childhood abuse and neglect affect adults' brains for decades to come - including their ability to process and act on information both quickly and accurately, new research suggests.

21 Jan 2016

Immunotherapy could be the future of cancer treatments

For decades most cancers have been treated with the standard of care treatments which typically include surgery, radiation and/or chemotherapy. Now there is talk that immunotherapy represents "the future of cancer treatments."

21 Jan 2016

Gene therapy holds considerable potential for safe, effective treatment of people with factor VII deficiency

Hematology researchers have used a single injection of gene therapy to correct a rare bleeding disorder, factor VII deficiency, in dogs. This success in large animals holds considerable potential for a safe, effective and long-lasting new treatment in humans with the same bleeding disorder.

21 Jan 2016

OncoGenex provides update on Phase 2 Spruce trial in patients with untreated metastatic NSCLC

OncoGenex Pharmaceuticals, Inc. announced today that data from the Phase 2 Spruce trial evaluating the combination of apatorsen with carboplatin and pemetrexed in patients with untreated metastatic non-small cell lung cancer (NSCLC) did not reach the statistical significance required to demonstrate a progression-free survival (PFS) benefit.

20 Jan 2016

Novel gene therapy treatment proves safe, effective for factor VII deficiency

A single injection. That's all someone with a factor VII deficiency would need for a life-long cure, thanks to a new gene therapy treatment developed in a collaboration of researchers at the University of North Carolina and The Children's Hospital of Philadelphia.

20 Jan 2016

Traditional acupuncture no better than fake acupuncture for treating menopause symptoms

A new study has revealed traditional Chinese acupuncture treatments are no better than fake acupuncture for treating menopause symptoms.

20 Jan 2016

Amorphous iron nanoparticles have potential to kill tumor cells

Amorphous iron nanoparticles have a specific toxicity in tumor cells. In the journal Angewandte Chemie, Chinese scientists describe their design and synthesis of a special amorphous state of nanoparticulate iron, which can locally release reactive iron species in the acidic and hydrogen peroxide rich environment of cancer cells, providing new possibilities for theranostics and chemodynamic therapies.

20 Jan 2016

New Georgia Tech research center launched to manufacture living cells for cell-based therapies

A $15.7 million grant from the Atlanta-based Marcus Foundation has helped launch a new Georgia Institute of Technology research center that will develop processes and techniques for ensuring the consistent, low-cost, large-scale manufacture of high-quality living cells used in cell-based therapies.

20 Jan 2016

Physiotherapy and occupational therapy not effective in patients with Parkinson's disease

New research from the University of Birmingham has shown that physiotherapy and occupational therapy do not produce improvements in quality of life for patients with mild to moderate Parkinson's disease.

20 Jan 2016

Electrical stimulation could regulate, synchronize beating properties of nascent heart muscle cells

Columbia Engineering researchers have shown, for the first time, that electrical stimulation of human heart muscle cells (cardiomyocytes) engineered from human stem cells aids their development and function.

20 Jan 2016

Therapy News and Research

PGD model could provide policy guideposts for human genome editing

Study throws light on why gout not well managed in many patients

Researchers use ASC secreted factors to create therapeutic factor concentrate for critical limb ischemia

Oral drug ivacaftor appears to be safe, beneficial to pre-school children with specific type of cystic fibrosis

Amgen announces approval of cholesterol-lowering medication Repatha (evolocumab) Injection in Japan

People suffering from chronic stress, anxiety may be at increased risk for depression and dementia

Champions Oncology begins prospective correlative trial of PDX in patients with sarcoma

FDA approves Allergan's sNDA to update label for DALVANCE (dalbavancin) for injection

Allergan announces publication of VIBERZI Phase III trial results in The New England Journal of Medicine

Psychological techniques help reduce body dissatisfaction in women with bulimia nervosa

Childhood abuse and neglect associated with worse executive function in adulthood

Immunotherapy could be the future of cancer treatments

Gene therapy holds considerable potential for safe, effective treatment of people with factor VII deficiency

OncoGenex provides update on Phase 2 Spruce trial in patients with untreated metastatic NSCLC

Novel gene therapy treatment proves safe, effective for factor VII deficiency

Traditional acupuncture no better than fake acupuncture for treating menopause symptoms

Amorphous iron nanoparticles have potential to kill tumor cells

New Georgia Tech research center launched to manufacture living cells for cell-based therapies

Physiotherapy and occupational therapy not effective in patients with Parkinson's disease

Electrical stimulation could regulate, synchronize beating properties of nascent heart muscle cells

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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