Major Depressive Disorder News and Research

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Major Depressive Disorder (MDD) is a psychiatric condition characterized by depressed mood or anhedonia (significant loss of interest or pleasure). The condition affects more than 15.7 million adults and approximately 3 million adolescents (aged 13 to 17 years) in the USA each year.

Sex differences in depression: Including transgender and intersex populations in mental health research

In 2016, recognizing that lack of research in female animals was hampering the success of treatments for mood disorders, the National Institutes of Health (NIH) changed its policy for basic research to include sex as a biological variable for basic research, a move that triggered an explosion of research into sex differences.

1 Aug 2023

Research reveals surprising genetic overlap between neurological and psychiatric disorders

Researchers compared the shared genetic risk and biological foundations of neurological and mental illnesses.

1 Aug 2023

Trial evaluates purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder

Researchers investigated the safety and pharmacokinetics of JNJ-54175446 in a double-blind, multicenter, randomized controlled trial (RCT).

31 Jul 2023

MUSC study to determine optimal dose of transcranial magnetic stimulation for MCI

With more than $3.7 million in funding from the National Institute on Aging, Medical University of South Carolina neuropsychologist Andreana Benitez, Ph.D., of the Department of Neurology in the College of Medicine will lead a phase II clinical trial to determine the optimal dose of transcranial magnetic stimulation, or TMS, needed to improve symptoms for patients with depression and mild cognitive impairment, or MCI.

28 Jul 2023

Amotivation and anhedonia play a crucial role in determining the social functioning of schizophrenia patients

Dr. Raymond Chan's team from the Institute of Psychology of the Chinese Academy of Sciences and his collaborators have recently shown that amotivation and anhedonia, rather than expressive dysfunction, play a crucial role in determining the social functioning of schizophrenia patients.

27 Jul 2023

Insights into the pathophysiological mechanisms governing neuropsychiatric symptoms of multiple sclerosis

Researchers pursued insights into the pathophysiological mechanisms governing neuropsychiatric symptoms of MS.

21 Jul 2023

Study finds highly specific polygenic signatures across multidimensional symptoms of bipolar disorder

Researchers analyzed the relationships between polygenic liability for bipolar disorder, schizophrenia, and major depressive disorder.

13 Jul 2023

Do the benefits of dog ownership on cardiovascular disease and diabetes extend to US military Veterans?

A study finds that dog ownership reduces the risk of cardiometabolic disease among US military veterans.

12 Jul 2023

Abnormal cortical folding linked to major depressive disorder

Major depressive disorder (MDD) is a complex and debilitating metal illness. Given its complex and widespread nature, MDD has been a subject of intense medical research.

10 Jul 2023

Depression after TBI may not be the same as depression related to other causes, study suggests

A new study led by Shan Siddiqi, MD, from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, suggests that depression after traumatic brain injury (TBI) could be a clinically distinct disorder rather than traditional major depressive disorder, with implications for patient treatment.

10 Jul 2023

TBI-associated depression may be a distinct disorder

A new study led by Shan Siddiqi, MD, from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, suggests that depression after traumatic brain injury (TBI) could be a clinically distinct disorder rather than traditional major depressive disorder, with implications for patient treatment.

5 Jul 2023

New biomarker for major depressive disorder identified

In appearance, the human brain's outermost layer, called the cortex, is a maze of tissue folds. The peaks or raised surfaces of these folds, called gyri, play an important role in the proper functioning of the brain.

4 Jul 2023

Using the power of machine learning to develop a predictive model of rumination

Our minds often get trapped in repetitive thoughts, such as past mistakes, regrets, insecurities, or unresolved conflicts.

29 Jun 2023

Multiple subtypes of major depressive disorder identified using brain imaging

Major depressive disorder (MDD) is not only among the most common mental illnesses, affecting over 8% of Americans, but it is also extremely variable from one person to another.

27 Jun 2023

New category of depression identified

Scientists at Stanford Medicine conducted a study describing a new category of depression - labeled the cognitive biotype - which accounts for 27% of depressed patients and is not effectively treated by commonly prescribed antidepressants.

23 Jun 2023

Magnetic stimulation treats depression by reversing the direction of abnormal brain signals

Powerful magnetic pulses applied to the scalp to stimulate the brain can bring fast relief to many severely depressed patients for whom standard treatments have failed.

23 May 2023

Researchers identify brain signatures for chronic pain in a small group of individuals

For the first time, researchers have recorded pain-related data from inside the brain of individuals with chronic pain disorders caused by stroke or amputation (phantom limb pain).

22 May 2023

Policy overhaul needed: Food industry's impact on global brain health

The dominance of the corporate-industrial food industry undermines brain capital and sustainable human development on a global scale. Understanding this impact is crucial for the future of public health and well-being.

17 May 2023

Study shows the power of gamma enhancement as potential approach for countering depression

Led by researchers from NYU Grossman School of Medicine and Hungary's University of Szeged, a new study in mice and rats found that restoring certain signals in a brain region that processes smells countered depression.

9 May 2023

Does physical activity impact substance use disorder treatment?

Researchers reviewed existing studies on physical activity interventions for treating substance use disorders.

28 Apr 2023