Signaling Pathway News and Research

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Study elucidates mechanism behind bacterial cancer therapy

A research team led by Prof. Liu Chenli from the Shenzhen Institutes of Advanced Technology of the Chinese Academy of Sciences (CAS) and Prof. Xiao Yichuan from the Shanghai Institute of Nutrition and Health of CAS elucidated the mechanism behind bacterial cancer therapy using a genetically engineered bacterial strain.

3 Mar 2025

St. Jude scientists discover how retinoic acid selectively kills metastatic neuroblastoma cells

Neuroblastoma is a solid tumor that occurs in children. When high-risk, the disease has a poor prognosis. Decades ago, adding the drug retinoic acid to neuroblastoma treatment increased survival by 10-15%.

2 Mar 2025

Researchers identify key gut cells involved in diarrhea response

Researchers from the Organoid group at the Hubrecht Institute have found that specific gut cells, BEST4/CA7+ cells, regulate electrolyte and water balance in response to bacterial toxins that cause diarrhea.

25 Feb 2025

Researchers discover key signaling pathway involved in atherosclerotic plaques

CD8+ T cells accumulate in atherosclerotic plaques. LMU researchers identify a crucial signaling pathway - with therapeutic potential.

25 Feb 2025

Study uncovers pathway behind age-related degeneration of eye glands

A team led by Mount Sinai researchers has identified stem cell populations and mechanisms underlying age-related degeneration in glands that are vital to eye function.

24 Feb 2025

Targeting FGFR mutations offers new hope for bone repair in skeletal disorders

Gain-of-function mutations in fibroblast growth factor receptor (FGFR) genes are known to cause a range of skeletal disorders, such as craniosynostosis and chondrodysplasia, which severely affect craniofacial and mandibular development.

21 Feb 2025

Novel therapeutic approaches targeting the Wnt pathway in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the deadliest cancers globally, with increasing incidence and mortality rates.

19 Feb 2025

Interferon pathway activation identified as key driver in OPLL pathogenesis

Ossification of the posterior longitudinal ligament (OPLL) is a progressive spinal disease characterized by ectopic bone formation in the spine, leading to severe neurological symptoms due to spinal cord compression. This condition is more prevalent in Asian countries and has been associated with various genetic and hormonal factors.

14 Feb 2025

KLX mitigates atherosclerotic progression by preventing EndMT

Atherosclerosis, a disease characterized by the accumulation of lipids and inflammatory cells in the arterial wall, is a significant cause of cardiovascular events.

13 Feb 2025

Immune gene expression changes in myocardial infarction revealed through bioinformatics

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This study was aimed at exploring immune-related genes and their expression changes in myocardial infarction (MI) through comprehensive bioinformatics methods and validating these genes as potential diagnostic and therapeutic targets.

8 Feb 2025

New gene modification enhances CAR-T cell effectiveness against cancer

Researchers have identified a method to enhance the effectiveness of a promising cancer treatment. They found that modifying a specific gene improves the ability of immune cells to combat cancer for an extended period, potentially reducing the chance of cancer recurring.

7 Feb 2025

Researchers discover strategy to slow brain metastases growth in melanoma

Brain metastases are one of the most severe complications of melanoma, the most aggressive type of skin cancer. Researchers at the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University (UMH) in Elche, have identified a strategy to slow their progression, which could improve the response to current treatments.

7 Feb 2025

How olive oil bioactives regulate genes linked to insulin resistance

Olive oil bioactives, including MUFAs, polyphenols, and triterpenoids, modulate gene expression linked to insulin sensitivity, inflammation, and beta-cell function, offering potential benefits for Type 2 Diabetes Mellitus prevention and management.

5 Feb 2025

Lycopene shows potential as a natural antidepressant

Emerging evidence suggests that lycopene-a natural plant extract-may have antidepressant properties. New research in Food Science & Nutrition reveals the mechanisms behind its antidepressant effects.

4 Feb 2025

New targeted therapy could bring relief to people with lichen planus

Mayo Clinic researchers have identified a targeted therapy that could bring relief to people living with lichen planus, a chronic inflammatory skin condition of the skin, hair, nails, mouth and genitals.

3 Feb 2025

Targeting MYCN and MDM2 offers new hope for cancer therapy

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality.

29 Jan 2025

Study reveals how glial cells respond to damage in neuron dendrites

Neurons may get all the glory, but they would be nothing without glial cells. While brain cells do the heavy lifting in the nervous system, it's the glia that provide nutrients, clean up waste, and protect neurons from harm.

29 Jan 2025

Extracellular vesicle miRNAs as potential early biomarkers for acute myocardial infarction

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This study sought to determine the potential of extracellular vesicle (EV) microRNAs (miRNAs) to serve as early diagnostic biomarkers for AMI.

17 Jan 2025

Tofacitinib reduces SARS-CoV-2 infection risk in patients with PTPN2 deficiency

Researchers report the ability of tofacitinib to reduce infection risk with SARS-CoV-2 in individuals who are deficient in PTPN2.

17 Jan 2025

Uncovering the neurobiological mechanisms of delta opioid receptor agonists

The global burden of anxiety- and depression-related disorders is on the rise. While multiple drugs have been developed to treat these conditions, current medications have several limitations, including slow action and adverse effects with long-term use. This underscores the urgent need for novel, rapidly-acting therapeutic agents with minimal side effects.

15 Jan 2025