Signaling Pathway News and Research

RSS

Male mice three times more likely than females to survive E. coli infection

Scientists at UC San Francisco have developed a new way of looking at sex-biased diseases that is rooted in evolutionary biology.

20 Oct 2022

Pathophysiological mechanisms of COVID-19-related endothelial dysfunction and potential therapies

Researchers discussed the pathophysiological mechanisms of endothelial dysfunction associated with severe coronavirus disease 2019 (COVID-19) and commented on the potential therapeutic strategies to treat endothelial damage and coagulopathy related to COVID-19.

19 Oct 2022

Do hypertension, dyslipidemia, and new-onset diabetes mellitus play a part in post-COVID sequelae?

A new study evaluated the current research on incidences of hypertension, new-onset diabetes mellitus, and dyslipidemia as possible sequelae of coronavirus disease 2019 (COVID-19).

18 Oct 2022

Bioinformatics analysis of monkeypox virus-host cell interactions

A recent study posted to the bioRxiv* preprint server reported the interaction between monkeypox and human cells. Molecular sequences were screened to identify differentially expressed genes (DEGs) and their associated signal pathway, expression regulation, and metabolic pathways.

18 Oct 2022

Study illuminates how pain neurons protect the gut from damage

Pain has been long recognized as one of evolution's most reliable tools to detect the presence of harm and signal that something is wrong -; an alert system that tells us to pause and pay attention to our bodies.

14 Oct 2022

The immunometabolic regulatory mechanisms for the pathogenesis of COVID-19

A new study aimed to analyze the immunometalobism BALF cells from mild to severe COVID-19 patients using computational algorithms that quantified metabolic fluxes and metabolic pathways.

13 Oct 2022

Study uncovers how the TAZ protein protects hematopoietic stem cells from aging

A well-functioning immune system is essential for protection against infections. However, with increasing age, the functioning of the immune system diminishes, which is also due to age-related damage in hematopoietic (blood) stem cells.

7 Oct 2022

Researchers discover potential therapeutic target for deadly brain tumors

Researchers at VCU Massey Cancer Center discovered a cellular partnership that drives the growth of deadly brain tumors and could potentially serve as a novel target for disease treatment.

5 Oct 2022

Study shows SARS-CoV-2 infects human adipose tissue and undergoes productive infection in fat cells

Researchers demonstrated infection of human adipose tissue by SARS-CoV-2.

5 Oct 2022

Study reveals a promising therapeutic target for spinocerebellar ataxia type 14

Spinocerebellar ataxias are a group of neurodegenerative diseases characterized by the degeneration of Purkinje cells, a major class of neurons in the cerebellum.

3 Oct 2022

Researchers discover a molecule that promotes tumor cell survival in retinoblastoma

Despite decades of medical advances, children who develop the pediatric eye cancer retinoblastoma often lose their vision or an eye due to a lack of specific, targeted therapies and a poor molecular understanding of the cancer.

3 Oct 2022

Plasma proteome signature predictive of occurrence of persistent symptoms following SARS-CoV-2 infection

In a new study, researchers performed a proteomic multiple-reaction monitoring analysis of 91 pre-selected proteins using the plasma samples of 156 healthcare workers (HCW) in the United Kingdom (UK).

30 Sep 2022

Oxytocin induces epicardial cell proliferation, study finds

The neurohormone oxytocin is well-known for promoting social bonds and generating pleasurable feelings, for example from art, exercise, or sex. But the hormone has many other functions, such as the regulation of lactation and uterine contractions in females, and the regulation of ejaculation, sperm transport, and testosterone production in males.

30 Sep 2022

Love hormone can activate heart repair mechanisms after cardiac injury, study finds

Researchers show for the first time that the neurohormone oxytocin has a previously unsuspected function in both zebrafish and human cell cultures: it stimulates mature cells in the epicardium of the heart to become stem-like cells, which can replace heart cells lost after damage.

30 Sep 2022

Study reveals key role of AKG/OXGR1 signaling pathway in maintaining male reproduction

Infertility is a global public health problem caused by genetic defects, lifestyle, nutrition, and factors affecting the local metabolism and microenvironment of the reproductive system.

26 Sep 2022

Researchers identify key gene network responsible for severe tooth enamel defects

Mutations in a certain molecule result in severe damage in the structure and mineral composition of tooth enamel in mice, according to a study conducted at the UZH Center of Dental Medicine.

26 Sep 2022

Combination of three existing drugs extends survival in mouse models of lethal brain cancer

A Ludwig Cancer Research study has identified a combination of three existing drugs that significantly extends survival in mouse models of the lethal brain cancer glioblastoma multiforme (GBM).

20 Sep 2022

Research reveals pivotal role of C/EBPb in the development of alveolar macrophages

If a secretion in the lungs’ alveoli is not cleared regularly, breathing difficulties can develop. In a study published in Science Immunology, a team led by Alexander Mildner and Achim Leutz has now explained the pivotal role of the transcription factor C/EBPb in this process.

16 Sep 2022

JGU researchers seek to gain a better understanding of depression

Human beings and fruit flies have very little in common - at first sight. However, studying these flies it is in fact possible to find out more about human nature, particularly when it comes to depressive disorders.

16 Sep 2022

Signal transduction via the EGFR pathway likely to be involved in lenvatinib resistance

The multitargeted tyrosine kinase inhibitor (MKI), lenvatinib, is widely used to treat advanced and metastatic thyroid cancer. However, the molecular mechanisms by which thyroid cancer cells become resistant to lenvatinib remain poorly understood. In this study, we demonstrated, for the first time, that activation of the epidermal growth factor receptor (EGFR)-mediated signaling pathway is involved in lenvatinib resistance in thyroid cancer cells.

14 Sep 2022

Signaling Pathway News and Research

Male mice three times more likely than females to survive E. coli infection

Pathophysiological mechanisms of COVID-19-related endothelial dysfunction and potential therapies

Do hypertension, dyslipidemia, and new-onset diabetes mellitus play a part in post-COVID sequelae?

Bioinformatics analysis of monkeypox virus-host cell interactions

Study illuminates how pain neurons protect the gut from damage

The immunometabolic regulatory mechanisms for the pathogenesis of COVID-19

Study uncovers how the TAZ protein protects hematopoietic stem cells from aging

Researchers discover potential therapeutic target for deadly brain tumors

Study shows SARS-CoV-2 infects human adipose tissue and undergoes productive infection in fat cells

Study reveals a promising therapeutic target for spinocerebellar ataxia type 14

Researchers discover a molecule that promotes tumor cell survival in retinoblastoma

Plasma proteome signature predictive of occurrence of persistent symptoms following SARS-CoV-2 infection

Oxytocin induces epicardial cell proliferation, study finds

Love hormone can activate heart repair mechanisms after cardiac injury, study finds

Study reveals key role of AKG/OXGR1 signaling pathway in maintaining male reproduction

Researchers identify key gene network responsible for severe tooth enamel defects

Combination of three existing drugs extends survival in mouse models of lethal brain cancer

Research reveals pivotal role of C/EBPb in the development of alveolar macrophages

JGU researchers seek to gain a better understanding of depression

Signal transduction via the EGFR pathway likely to be involved in lenvatinib resistance

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

Latest News