Cell Death News and Research

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Study reveals gene linked to metastatic melanoma

A study by Craig J. Ceol, PhD, assistant professor of molecular medicine at the University of Massachusetts Medical School, has revealed a protein active during early embryo development called GDF6 plays a primary role in metastatic melanoma.

4 Dec 2017

Chemotherapy-generated debris from dead and dying cancer cells can stimulate tumor growth

Cancer therapies including radiation and chemotherapy seek to treat the disease by killing tumor cells. Now a team including researchers at Beth Israel Deaconess Medical Center have shown that the dead and dying cancer cells generated by chemotherapy and targeted cancer therapy paradoxically trigger inflammation that promotes aggressive tumor growth.

1 Dec 2017

Scientists identify new strategies used by Helicobacter pylori to target mitochondria

Helicobacter pylori is a bacterial pathogen that colonizes the stomach of approximately half of the world's population. Infection with H. pylori is acquired in childhood and lasts for decades.

29 Nov 2017

USC researchers propose rules for making ribs

Scientists from the USC Stem Cell lab of Francesca Mariani recently shared a recipe for ribs, and it doesn't even require barbecue sauce.

29 Nov 2017

Process of removing cellular debris can fuel tumor growth in metastatic prostate cancer

The goal of any cancer treatment is to kill tumor cells. Yet, one little understood paradox of certain cancers is that the body's natural process for removing dead and dying cells can actually fuel tumor growth.

28 Nov 2017

Researchers explore new method of destroying tumor cells

Researchers from Lomonosov MSU Faculty of Biology have studied the stages of entosis, a process of cell death when one cell invades the other and gets digested inside of it. Entosis could become a new method of destroying cancer cells.

27 Nov 2017

New study shows how SNO reaction may contribute to Parkinson's disease

A new study from The Scripps Research Institute is the first to show precisely how a process in nerve cells called the S-nitrosylation (SNO) reaction- which can be caused by aging, pesticides and pollution- may contribute to Parkinson's disease.

22 Nov 2017

High-fat diet during lactation alters RNA activity in breast milk, research suggests

New research suggests that following a high-fat diet during lactation - regardless of diet during pregnancy - alters RNA activity in breast milk. The changes in genetic material may increase the risk of metabolic disorders such as type 2 diabetes in offspring. The article is published ahead of print in Physiological Genomics.

21 Nov 2017

Study shows how naïve T-cells may affect tumor immunity and immunotherapy

The immune cells that are trained to fight off the body's invaders can become defective. It's what allows cancer to develop. So most research has targeted these co-called effector T-cells.

17 Nov 2017

Mount Sinai researchers identify new therapeutic target for ER+ breast cancer

Researchers at the Icahn School of Medicine at Mount Sinai have identified a protein that can be targeted to suppress growth of a common type of breast cancer known as "estrogen receptor positive" (ER+), including ER+ cancers that are resistant to standard treatments.

17 Nov 2017

Hibernating ground squirrels offer clues to fight against stroke-induced brain damage

In the fight against brain damage caused by stroke, researchers have turned to an unlikely source of inspiration: hibernating ground squirrels.

17 Nov 2017

Biologists resolve immune protein structure to provide insight into pathogen-defense strategies

Biologists have resolved the structure of a ring of proteins used by the immune system to summon support when under attack, providing new insight into potential strategies for protection from pathogens.

17 Nov 2017

Breakthrough research brings new procedure closer to helping patients with blood cancer

A new procedure that can prevent the potentially lethal side effects of stem cell transplants is a step closer to helping more patients with blood cancers after a breakthrough in understanding of the key mechanism that makes it work.

17 Nov 2017

Research reveals fundamental process used by immune system to recognize invading pathogens

The body's homeland security unit is more thorough than any airport checkpoint. For the first time, scientists have witnessed a mouse immune system protein frisking a snippet of an invading bacterium. The inspection is far more extensive than researchers imagined: the immune system protein, similar to those in humans, scans the bacterial protein in six different ways, ensuring correct identification.

16 Nov 2017

AstraZeneca’s new precision biologic gets FDA approval to treat severe eosinophilic asthma

AstraZeneca and its global biologics research and development arm, MedImmune, today announced that the US Food and Drug Administration has approved FASENRA (benralizumab) for the add-on maintenance treatment of patients with severe asthma aged 12 years and older, and with an eosinophilic phenotype.

14 Nov 2017

Dresden researchers develop molecular smoke alert for key human cancer gene

If it burns in a house smoke detectors alert us hence protecting life. A molecular smoke alert has now been developed by Dresden researchers for the TP53 gene, the most important human cancer gene. The alert goes on if the TP53 gene is mutated in cells.

14 Nov 2017

Corneal donor tissue can be safely stored for longer period, study finds

Results from a large, national clinical trial show that corneal donor tissue can be safely stored for 11 days without negatively impacting the success of transplantation surgery to restore vision in people with diseases of the cornea.

10 Nov 2017

Study identifies promising treatment to reduce brain injury in babies

Research-clinicians at Children's National Health System led the first study to identify a promising treatment to reduce or prevent brain injury in newborns who have suffered hypoxia-ischemia, a serious complication in which restricted blood flow deprives the brain of oxygen.

10 Nov 2017

Researchers catch killer cells red-handed in the act of microbial murder

Immune cells called "killer cells" target bacteria invading the body's cells, but how do they do this so effectively? Bacteria can quickly evolve resistance against antibiotics, yet it seems they have not so readily been able to evade killer cells. This has caused researchers to become interested in finding out the exact mechanism that killer cells use to destroy bacterial invaders.

9 Nov 2017

Chronic liver inflammation promotes cancer by suppressing immunosurveillance, study finds

Chronic inflammation is known to drive many cancers, especially liver cancer. Researchers have long thought that's because inflammation directly affects cancer cells, stimulating their division and protecting them from cell death.

8 Nov 2017

Cell Death News and Research

Study reveals gene linked to metastatic melanoma

Chemotherapy-generated debris from dead and dying cancer cells can stimulate tumor growth

Scientists identify new strategies used by Helicobacter pylori to target mitochondria

USC researchers propose rules for making ribs

Process of removing cellular debris can fuel tumor growth in metastatic prostate cancer

Researchers explore new method of destroying tumor cells

New study shows how SNO reaction may contribute to Parkinson's disease

High-fat diet during lactation alters RNA activity in breast milk, research suggests

Study shows how naïve T-cells may affect tumor immunity and immunotherapy

Mount Sinai researchers identify new therapeutic target for ER+ breast cancer

Hibernating ground squirrels offer clues to fight against stroke-induced brain damage

Biologists resolve immune protein structure to provide insight into pathogen-defense strategies

Breakthrough research brings new procedure closer to helping patients with blood cancer

Research reveals fundamental process used by immune system to recognize invading pathogens

AstraZeneca’s new precision biologic gets FDA approval to treat severe eosinophilic asthma

Dresden researchers develop molecular smoke alert for key human cancer gene

Corneal donor tissue can be safely stored for longer period, study finds

Study identifies promising treatment to reduce brain injury in babies

Researchers catch killer cells red-handed in the act of microbial murder

Chronic liver inflammation promotes cancer by suppressing immunosurveillance, study finds

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