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Glucosidase inhibitors hold promise as novel therapeutic agents against SARS-CoV-2

In a new study posted to the bioRxiv* preprint server, researchers from the United States report that two iminosugar glucosidase inhibitors have the ability to suppress the replication of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in tissue culture – at concentrations of at least 100 times lower than required for cytotoxic effects.

19 May 2021

A SARS-CoV-2 neutralizing antibody with extensive spike binding coverage

In a recently published research paper in the journal Nature Communications, a team of scientists from China has described the antiviral efficacy of a novel anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody isolated from recovered coronavirus disease 2019 (COVID-19) patients.

17 May 2021

Phosphatidic acid is a key common substrate for hepatitis C and SARS-CoV-2 replication

A new study, released as a preprint on the bioRxiv* server, focuses on the lipid molecule called phosphatidic acid (PA), showing its crucial role in the replication of this virus, and thus its potential as a target for therapeutic intervention.

13 May 2021

Designer SARS-CoV-2 RBD vaccine produces dramatically improved antibody response in preclinical trials

The importance of computational modeling in the prediction of the course of the ongoing COVID-19 pandemic, as well as evaluating multiple potential drug leads, has never been more clear. Now, a new study describes a set of designer vaccine antigens that may improve vaccine stability as well as enhance the neutralizing antibody response.

13 May 2021

Study uses advances in medical imaging to visualize white matter pathways in fetuses

Researchers from the £12 million Developing Human Connectome Project have used the dramatic advances in medical imaging the project has provided to visualize and study white matter pathways, the wiring that connects developing brain networks, in the human brain as it develops in the womb.

12 May 2021

LLNL-developed thin-film electrodes generate never-before-seen recordings of brain activity

Thin-film electrodes developed at Lawrence Livermore National Laboratory have been used in human patients at the University of California, San Francisco, generating never-before-seen recordings of brain activity in the hippocampus, a region responsible for memory and other cognitive functions.

12 May 2021

New noninvasive imaging device could be used in biomedical research, translational medicine

A biochemical reaction between an enzyme called luciferase and oxygen causes fireflies to glow and is considered one of the most well-known examples of bioluminescence in nature.

12 May 2021

An intranasal COVID-19 vaccine elicits long-lasting immunity against SARS-CoV-2 variants in vivo

A team of scientists from the Washington University School of Medicine and the University of Texas Medical Branch, USA, has recently evaluated the durability and robustness of an adenovirus-vectored, spike-based intranasal COVID-19 vaccine in mice.

11 May 2021

Novel 'CopyCatcher' detects when precise copying of genetic information takes place in cells

Researchers at the University of California San Diego have laid the groundwork for a potential new type of gene therapy using novel CRISPR-based techniques.

11 May 2021

Natural products a rich source for novel antiviral compounds

In a recent review in the journal Viruses, researchers look at natural products that can be identified as potential alternative antiviral agents. The reviewers discussed the antiviral activities of several natural products towards DNA and RNA viruses with an analytical approach. The researchers detailed the cellular/viral targets of the active molecules and their impact on the infection and viral replication cycle.

10 May 2021

Blocking fat-busting enzyme with a drug compromises cardiac repair during acute heart failure

Blocking the fat-busting enzyme lipoxygenase with a synthetic inhibitor throws the immune system's innate inflammatory response out of whack, compromising cardiac repair during acute heart failure, USF Health researchers found.

10 May 2021

Compound from tropical ginger plant can help in the treatment of inflammatory diseases

Many natural compounds have various anti-inflammatory and other beneficial properties that humans have been utilizing for medicinal purposes for hundreds of years.

7 May 2021

Brain-targeting drug delivery with nano-scaled apoptotic bodies

Scientists from Nanjing University and University of Macau have discovered nano-scaled apoptotic bodies (ABs) as a new brain-targeting drug carrier, bringing new promise for the Parkinson's Disease as well as other brain diseases.

7 May 2021

Researchers report encouraging results from experimental antiviral targeting Marburg virus

The Marburg virus, a relative of the Ebola virus, causes a serious, often-fatal hemorrhagic fever. Transmitted by the African fruit bat and by direct human-to-human contact, Marburg virus disease currently has no approved vaccine or antivirals to prevent or treat it.

7 May 2021

SARS-CoV-2 is activated for fusion by a broad range of proteases, finds study

A team of researchers from the University of Virginia, USA, used single-virus fusion experiments with exogenously controlled proteases to investigate the mechanism of activation directly. They found that the subcellular location of entry depends on the protease activity of the various components, and parallel pathways are possible.

6 May 2021

Study: Repeated vape aerosol exposure causes minimal lung damage compared to combustible cigarettes

In one of the most advanced applications of in-vitro 3D human lung models in vape research to date, a new peer-reviewed Imperial Brands study shows that, unlike combustible cigarette smoke, blu aerosol had little to no impact on numerous toxicological endpoints under the conditions of test using laboratory models.

6 May 2021

Researchers identify potent small molecule TMPRSS2 inhibitor against SARS-CoV-2

A team of scientists from the USA and Canada has recently identified and characterized a novel small-molecule compound inhibitor of cellular serine protease TMPRSS2, which shows significant antiviral potency against emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

5 May 2021

Repurposing an existing, cheap drug into long-acting injectable therapy to treat Covid-19

Researchers from the University of Liverpool have shown the potential of repurposing an existing and cheap drug into a long-acting injectable therapy that could be used to treat Covid-19.

5 May 2021

Nanoparticle (SpFN) vaccine candidate elicits multifactorial cellular immune responses against SARS-CoV-2 in vivo

Researchers have developed a promising new anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)vaccine candidate that utilizes nanotechnology and shows robust, long-lived immunity in mouse models.

5 May 2021

Mechano-immunological response to SARS-CoV-2

In a recent study, researchers demonstrated a human organ-on-a-chip (Organ Chip) microfluidic model of the lung alveolus (Alveolus Chip) - that recapitulates the human alveolar-capillary interface with an air-liquid interface (ALI) and vascular fluid flow to understand the local triggers in the lung in vitro.

5 May 2021

in vivo News and Research

Glucosidase inhibitors hold promise as novel therapeutic agents against SARS-CoV-2

A SARS-CoV-2 neutralizing antibody with extensive spike binding coverage

Phosphatidic acid is a key common substrate for hepatitis C and SARS-CoV-2 replication

Designer SARS-CoV-2 RBD vaccine produces dramatically improved antibody response in preclinical trials

Study uses advances in medical imaging to visualize white matter pathways in fetuses

LLNL-developed thin-film electrodes generate never-before-seen recordings of brain activity

New noninvasive imaging device could be used in biomedical research, translational medicine

An intranasal COVID-19 vaccine elicits long-lasting immunity against SARS-CoV-2 variants in vivo

Novel 'CopyCatcher' detects when precise copying of genetic information takes place in cells

Natural products a rich source for novel antiviral compounds

Blocking fat-busting enzyme with a drug compromises cardiac repair during acute heart failure

Compound from tropical ginger plant can help in the treatment of inflammatory diseases

Brain-targeting drug delivery with nano-scaled apoptotic bodies

Researchers report encouraging results from experimental antiviral targeting Marburg virus

SARS-CoV-2 is activated for fusion by a broad range of proteases, finds study

Study: Repeated vape aerosol exposure causes minimal lung damage compared to combustible cigarettes

Researchers identify potent small molecule TMPRSS2 inhibitor against SARS-CoV-2

Repurposing an existing, cheap drug into long-acting injectable therapy to treat Covid-19

Nanoparticle (SpFN) vaccine candidate elicits multifactorial cellular immune responses against SARS-CoV-2 in vivo

Mechano-immunological response to SARS-CoV-2

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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