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Advancements in antibody-drug conjugates transform cancer therapy

Antibody-drug conjugates (ADCs) have emerged as a promising approach in cancer therapy, offering a 'magic bullet' strategy that combines the precision of monoclonal antibodies with the potency of cytotoxic drugs.

22 Oct 2024

Tissue stiffening linked to disease progression in HER2-negative breast cancer

A study published in Clinical Cancer Research confirmed that tissue stiffening in the most common types of breast cancer, HER2-negative, can directly cause disease progression and metastasis, leading to detrimental outcomes for patients.

22 Oct 2024

Physical tests offer prognostic insights for lung cancer patients

A study of patients with metastatic lung cancer by researchers based in Brazil and the United States has found that their performance in simple physical tests such as sitting down, standing and walking can help physicians arrive at a prognosis and approach to treatment.

22 Oct 2024

MRI can spare many patients with rectal cancer from invasive surgery

Magnetic resonance imaging (MRI) can spare many patients with rectal cancer from invasive surgery that can carry lifelong side effects, new research indicates.

22 Oct 2024

New antibody targets cancer-causing HER2 mutations

For some proteins, a single mutation, or change in its DNA instructions, is all it takes to tip the balance between functioning normally and causing cancer.

22 Oct 2024

New CAR T cells offer controlled treatment for solid tumors

Ludwig Cancer Research scientists have devised new types of chimeric antigen-receptor (CAR) T cells - a type of cancer immunotherapy - that can be switched on to varying degrees of intensity and then switched off on demand with existing drugs.

21 Oct 2024

New light-activated technology enhances immune cells' ability to target solid tumors

Immunotherapies that mobilize a patient's own immune system to fight cancer have become a treatment pillar. These therapies, including CAR T-cell therapy, have performed well in cancers like leukemias and lymphomas, but the results have been less promising in solid tumors.

21 Oct 2024

New PET scan effectively detects benign insulinomas in the pancreas

A new PET scan reliably detects benign tumors in the pancreas, according to research led by Radboud university medical center.

21 Oct 2024

Novel antibodies show promise for tumor targeting and RAD51 inhibition

A new research paper was published in Oncotarget's Volume 15 on October 1, 2024, entitled, "Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition."

21 Oct 2024

Scientists reveal how miRNAs shape cancer and offer new paths for treatment

Review explores how microRNAs (miRNAs) interact in cancer development, their potential in diagnosis, and innovative therapeutic strategies, including overcoming chemotherapy resistance.

20 Oct 2024

Studies reveal unique challenges faced by younger patients with colorectal cancer

Younger adults with colon cancer tend to be diagnosed at a later stage and have more aggressive types of tumors.

18 Oct 2024

Understanding cardiovascular risks in endometriosis patients

Endometriosis increases the risk of cardiovascular events.

18 Oct 2024

New risk calculators empower thoracic surgeons

The Society of Thoracic Surgeons (STS) announces the release of two new risk calculators to inform physician-patient decision-making in thoracic surgery. Engineered using contemporary data from the STS General Thoracic Surgery Database, these interactive tools provide surgeons with accurate, preoperative risk estimations for outcomes of esophagectomy for cancer and pulmonary resection for lung cancer.

18 Oct 2024

ALS drug shows promise in targeting glioblastoma stem cells

Glioblastoma is the most common – and the most malignant – primary brain tumor in adults. It's aggressive and incurable.

17 Oct 2024

New diagnostic test aims for same-day detection of leptomeningeal disease

With time being of the essence for patients facing one of cancer's most dire complications, UCLA researchers are working to create a new test to detect cancer's spread to the central nervous system on the same day as the doctor's visit.

17 Oct 2024

Study links healthy diet to reduced progression of low-risk prostate cancer

In a peer-reviewed study believed to be the first of its kind published, a research team led by Johns Hopkins Medicine provides scientific evidence that a healthy diet may reduce the chance of low risk prostate cancer progressing to a more aggressive state in men undergoing active surveillance - a clinical option in which men with lower risk cancer are carefully monitored for progression in lieu of treatments that could have undesired side effects or complications.

17 Oct 2024

Edaravone shows promise in targeting brain tumor stem cells

Glioblastomas are aggressive brain tumors with a median survival time of less than 22 months despite standard therapy including surgery, irradiation, and chemotherapy.

17 Oct 2024

Study identifies biomarkers for immunotherapy success in liver cancer

It may soon be possible to determine which patients with a type of liver cancer called hepatocellular carcinoma would benefit from immunotherapy, according to a preclinical study by Weill Cornell Medicine investigators.

17 Oct 2024

Innovative sensor material offers non-invasive cancer diagnosis

A research team led by Dr. Ho Sang Jung of the Advanced Bio and Healthcare Materials Research Division at the Korea Institute of Materials Science has developed an innovative sensor material that amplifies the optical signals of cancer metabolites in body fluids (saliva, mucus, urine, etc.) and analyzes them using artificial intelligence to diagnose cancer.

17 Oct 2024

New grant aims to transform treatment for liver cancer

Currently, there are a few available treatment options for liver cancer, including a combination of immunotherapies and a class of drugs known as tyrosine kinase inhibitors (TKIs), but their long-term effects are limited.

17 Oct 2024