immunity News and Research

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Does a second monovalent SARS-CoV-2 mRNA booster increase neutralizing activity to Omicron variants in nursing home residents and healthcare workers?

Researchers investigated whether the second booster dose of monovalent COVID-19 mRNA vaccines increases antibody titers and neutralization potential against the SARS-CoV-2 Omicron VOC among NH residents and HCWs.

30 Jan 2023

Study suggests robust lung mucosal immunity against SARS-CoV-2 can be better achieved through hybrid immunity, as opposed to peripheral vaccination alone

Researchers characterized immunological responses by pulmonary mucosal tissues post-COVID-19 vaccination and/or SARS-CoV-2 infection, to assess the impact of hybrid immune protection on the durability of mucosal immunological responses.

30 Jan 2023

Scientists Develop a Cancer Vaccine to Simultaneously Kill and Prevent Brain Cancer

Dual-action cell therapy engineered to eliminate established tumors and train the immune system to eradicate primary tumor and prevent cancer’s recurrence.

30 Jan 2023

NUS scientists breathe new life into an existing drug to fight T-cell acute lymphoblastic leukemia

A team of researchers from the Cancer Science Institute of Singapore at the National University of Singapore, led by Associate Professor Takaomi Sanda and Dr Lim Fang Qi, has breathed new life into an existing drug—combatting a type of blood cancer called T-cell acute lymphoblastic leukemia, or T-ALL.

30 Jan 2023

Study evaluates SARS-CoV-2-specific antibody response in human milk

In a recent study published in the journal Communications Biology, researchers investigated the effect of the coronavirus disease 2019 (COVID-19) vaccine booster on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies in the milk of lactating women. Additionally, they explored whether the booster-induced antibody response differed from the homologous and heterologous boosting schedule of their primary vaccination.

29 Jan 2023

Antiviral activity of natural flavonoids against various coronaviruses

A recent study describes the binding affinity and docking sites of several natural compounds, as well as their inhibitory activity against 3CLpro.

29 Jan 2023

Pregnancy has no effect on long-term immune response to SARS-CoV-2 mRNA vaccination

The immunologic milieu of pregnancy has no effect on the durability of the anti-S IgG response to COVID-19 vaccination

29 Jan 2023

Researchers discover the impact of microRNA on inflammation in lupus

A group of researchers from the Graduate School of Medicine at Nagoya University in Japan have discovered the impact of microRNA (miRNA) on inflammation in lupus in mice.

26 Jan 2023

F-box gene mediates dietary restriction effects on extending the health span of C. elegans

A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 1, entitled, "The innate immune signaling component FBXC-58 mediates dietary restriction effects on healthy aging in Caenorhabditis elegans."

25 Jan 2023

FDA briefing discusses different COVID-19 vaccination regimens

In a recent briefing document published by the United States Food and Drug Administration (US-FDA) ahead of an advisory committee meeting scheduled for January 26, 2023, the national agency proposed that people should be given yearly coronavirus disease 2019 (COVID-19) vaccines.

25 Jan 2023

Data demonstrates SARS-CoV-2 Omicron XBB.1.5 substantially escapes NAb responses after bivalent mRNA boosting

Researchers reported that the SARS-CoV-2 Omicron XBB.1.5 variant evades neutralizing response elicited by bivalent vaccine boosters.

25 Jan 2023

Targeting newly discovered signaling pathway could boost the potency of cancer therapeutics

Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome - a cell's complete set of DNA - is most vulnerable while it is being duplicated before a cell divides. Cancer cells constantly are dividing, so their genomes are constantly in jeopardy.

24 Jan 2023

Mosaic RBD nanoparticles offer 100% protection against SARS-CoV-2 in animal model

A recent PNAS journal study has sought to address the above-stated drawback and developed a new strategy that involves a self-assembling scaffold of proliferating cell nuclear antigen (PCNA). This technique can develop nanoparticles containing evenly incorporated heterotypic antigens.

24 Jan 2023

Survey of previously vaccinated US residents finds the most common reasons for not getting an updated COVID-19 vaccine

Researchers described reasons cited by adults for receiving or not receiving COVID-19 booster vaccines.

24 Jan 2023

Dietary plant sugar promotes antitumor immunity and enhances the efficacy of immunotherapy

Immunotherapies have improved outcomes of many patients with cancer, including melanoma. But these therapies work for only a subset of patients.

23 Jan 2023

Study reviews mechanistic data on new methods of allergy prevention and treatment

In a recent article published in Science Translational Medicine, researchers reviewed the cause and the underlying pathophysiology of allergic diseases.

23 Jan 2023

Genetic disorder that causes immunodeficiency and susceptibility to opportunistic infections discovered

An international consortium co-led by Vanderbilt University Medical Center immunogeneticist Rubén Martínez-Barricarte, PhD, has discovered a new genetic disorder that causes immunodeficiency and profound susceptibility to opportunistic infections including a life-threatening fungal pneumonia.

23 Jan 2023

SARS-CoV-2 Omicron XBB.1.5, CA.3.1, and CH.1.1 exhibit remarkable antibody resistance

In a recent study posted to bioRxiv* preprint server, researchers at Ohio State University examined the degree of neutralizing antibody (nAb) evasion by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron XBB.1.5, CA.3.1, and CH.1.1 subvariants.

23 Jan 2023

People with hybrid immunity are the most protected against severe COVID-19 and reinfection

A University of Calgary research group - which includes several Bachelor of Health Sciences alumni joined forces with members of the World Health Organization to tackle a global health question.

20 Jan 2023

How effective are prior SARS-CoV-2 infections and hybrid immunity against Omicron breakthrough infections?

Researchers performed a systematic review and meta-regression study to determine the breadth and duration of the protective immunity conferred by previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and hybrid immunity.

20 Jan 2023

immunity News and Research

Does a second monovalent SARS-CoV-2 mRNA booster increase neutralizing activity to Omicron variants in nursing home residents and healthcare workers?

Study suggests robust lung mucosal immunity against SARS-CoV-2 can be better achieved through hybrid immunity, as opposed to peripheral vaccination alone

Scientists Develop a Cancer Vaccine to Simultaneously Kill and Prevent Brain Cancer

NUS scientists breathe new life into an existing drug to fight T-cell acute lymphoblastic leukemia

Study evaluates SARS-CoV-2-specific antibody response in human milk

Antiviral activity of natural flavonoids against various coronaviruses

Pregnancy has no effect on long-term immune response to SARS-CoV-2 mRNA vaccination

Researchers discover the impact of microRNA on inflammation in lupus

F-box gene mediates dietary restriction effects on extending the health span of C. elegans

FDA briefing discusses different COVID-19 vaccination regimens

Data demonstrates SARS-CoV-2 Omicron XBB.1.5 substantially escapes NAb responses after bivalent mRNA boosting

Targeting newly discovered signaling pathway could boost the potency of cancer therapeutics

Mosaic RBD nanoparticles offer 100% protection against SARS-CoV-2 in animal model

Survey of previously vaccinated US residents finds the most common reasons for not getting an updated COVID-19 vaccine

Dietary plant sugar promotes antitumor immunity and enhances the efficacy of immunotherapy

Study reviews mechanistic data on new methods of allergy prevention and treatment

Genetic disorder that causes immunodeficiency and susceptibility to opportunistic infections discovered

SARS-CoV-2 Omicron XBB.1.5, CA.3.1, and CH.1.1 exhibit remarkable antibody resistance

People with hybrid immunity are the most protected against severe COVID-19 and reinfection

How effective are prior SARS-CoV-2 infections and hybrid immunity against Omicron breakthrough infections?

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