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Unlocking the code: BigRNA's deep learning model predicts RNA behavior

Researchers have developed BigRNA, a groundbreaking deep learning model capable of predicting RNA behavior, including tissue-specific expression and splicing, directly from genomic DNA sequences. The model excels in identifying pathogenic variants and could be a game-changer in the development of personalized RNA-based therapies for treating genetic diseases.

28 Sep 2023

Insights and new directions in basic, clinical research into neurodegenerative diseases

A special supplement to the Journal of Alzheimer's Disease, published by IOS Press, presents insights and new directions in both basic and clinical research into neurodegenerative diseases.

28 Sep 2023

Blocking Notch signaling pathway could reverse age-related bone loss

A cellular signal essential to the development of the skeleton increases during aging to weaken bones, finds a new study in mice.

27 Sep 2023

Genetic markers could help identify people at risk for metabolic dysfunction-associated steatotic liver disease

An astounding 30% of Americans currently have metabolic dysfunction-associated steatotic liver disease, or MASLD, which is formerly known as nonalcoholic fatty liver disease, or NAFLD.

27 Sep 2023

Arrayed CRISPR Screening for Revolutionizing Target Discovery

In this interview conducted at SLAS EU 2023 in Brussels, Belgium, we spoke to Ulrike Kuenzel, Associate Director in the Functional Genomics department at AstraZeneca about the application of arrayed CRISPR screening for target identification and more.

From Society for Laboratory Automation and Screening (SLAS) 27 Sep 2023

$10.2M NIH grant awarded to study risk factors for malignant arrhythmias in mitral valve prolapse

Researchers at the Icahn School of Medicine at Mount Sinai have been awarded a $10.2 million grant from the National Heart, Lung and Blood Institute of the National Institutes of Health to investigate risk factors for malignant arrhythmias in mitral valve prolapse.

26 Sep 2023

Gene-silencer study could pave the way for novel cancer therapeutics

Deep inside our cells - each one complete with an identical set of genes - a molecular machine known as PRC2 plays a critical role in determining which cells become heart cells, versus brain or muscle or skin cells.

26 Sep 2023

SRI spins off a biosciences platform that accelerates drug discovery

SRI International announced today it is spinning off Synfini, a biosciences platform that accelerates the process by which pharmaceutical and other companies can design, synthesize, and bring to market molecules for drug development.

26 Sep 2023

Research could lead to the development of new weight-loss drug that mimics exercise

A brand-new kind of drug, tested in mice, shows promising new results that could lead to the development of a new weight-loss drug that mimics exercise.

25 Sep 2023

UMMC transplant team performs second pig heart transplant on patient with end-stage heart disease

After world's first successful transplant in 2022, also performed at the University of Maryland Medical Center (UMMC), this groundbreaking transplant team performed second pig heart transplant on patient deemed ineligible for traditional heart transplant.

25 Sep 2023

New model paves way to understanding and preventing SUDEP in familial epilepsy

Researchers at the University of Michigan have developed a model for studying one type of familial epilepsy, opening the door to understanding—and eventually targeting—the mechanisms that lead to the disorder and its associated fatalities.

25 Sep 2023

The power of nanobodies: How they impact COVID-19 immune response

The structures of 340 antibodies (Abs) and 83 nanobodies.

25 Sep 2023

Clinical study launched to test the benefits of immune modulation for hospitalized COVID-19 patients

A clinical trial has launched to test whether early intensive immune modulation for hospitalized COVID-19 patients with relatively mild illness is beneficial.

22 Sep 2023

VAX-seq: the future of mRNA vaccine analysis and quality assurance?

Researchers proposed a simplified approach for analyzing mRNA vaccines using long-read sequencing.

22 Sep 2023

Unlocking the power of mRNA vaccines: From COVID-19 to cancer and beyond

A comprehensive review in Signal Transduction and Targeted Therapy delves into the versatility and effectiveness of mRNA vaccines, from their game-changing role in COVID-19 to potential applications in cancer and rare diseases. Despite drawbacks like stability and high immunogenicity, advancements in vaccine technology have poised mRNA platforms as a robust tool for both preventive and therapeutic interventions.

21 Sep 2023

ACT and personalized cancer vaccine combo shows efficacy in ovarian cancer patients

A Ludwig Cancer Research study has shown that combining adoptive T cell therapy (ACT) with an innovative, personalized cancer vaccine under development at the Lausanne Branch of the Ludwig Institute for Cancer Research can benefit patients with late-stage, drug-resistant ovarian cancer.

21 Sep 2023

Weill Cornell Medicine receives NIH grant to lead a national contraceptive research center

Weill Cornell Medicine has received a three-year, nearly $6 million grant to lead one of three national contraceptive research centers.

21 Sep 2023

Scientists uncover a crucial component for restoring functional activity after spinal cord injury

In a new study in mice, a team of researchers from UCLA, the Swiss Federal Institute of Technology, and Harvard University have uncovered a crucial component for restoring functional activity after spinal cord injury.

21 Sep 2023

Can deep brain stimulation unlock the cure for severe depression?

A multidisciplinary team of clinicians, engineers, and neuroscientists has identified a unique biomarker in the brain that indicates recovery from treatment-resistant depression, utilizing deep brain stimulation (DBS) and artificial intelligence. The discovery, which allows for real-time monitoring and tailoring of treatment, could revolutionize the approach to managing severe forms of depression.

21 Sep 2023

UQ researchers identify novel drug target to overcome cancer drug resistance

University of Queensland researchers have identified a novel drug target with the potential to overcome drug resistance and prevent tumor regrowth in cancer patients.

20 Sep 2023

Therapeutics News and Research

Unlocking the code: BigRNA's deep learning model predicts RNA behavior

Insights and new directions in basic, clinical research into neurodegenerative diseases

Blocking Notch signaling pathway could reverse age-related bone loss

Genetic markers could help identify people at risk for metabolic dysfunction-associated steatotic liver disease

Arrayed CRISPR Screening for Revolutionizing Target Discovery

$10.2M NIH grant awarded to study risk factors for malignant arrhythmias in mitral valve prolapse

Gene-silencer study could pave the way for novel cancer therapeutics

SRI spins off a biosciences platform that accelerates drug discovery

Research could lead to the development of new weight-loss drug that mimics exercise

UMMC transplant team performs second pig heart transplant on patient with end-stage heart disease

New model paves way to understanding and preventing SUDEP in familial epilepsy

The power of nanobodies: How they impact COVID-19 immune response

Clinical study launched to test the benefits of immune modulation for hospitalized COVID-19 patients

VAX-seq: the future of mRNA vaccine analysis and quality assurance?

Unlocking the power of mRNA vaccines: From COVID-19 to cancer and beyond

ACT and personalized cancer vaccine combo shows efficacy in ovarian cancer patients

Weill Cornell Medicine receives NIH grant to lead a national contraceptive research center

Scientists uncover a crucial component for restoring functional activity after spinal cord injury

Can deep brain stimulation unlock the cure for severe depression?

UQ researchers identify novel drug target to overcome cancer drug resistance

Event guide: The Non-Opioid Pain Therapeutics Summit eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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