Mutation News and Research

RSS

Study finds mutational changes in Omicron variant likely increase transmissibility

A new study presented evidence for a large number of mutational changes in the Omicron variant which will likely increase its transmissibility and significantly decrease the neutralization capacity of monoclonal antibodies, leading to a decline in vaccine efficacy.

10 Dec 2021

Mutational landscape of SARS-CoV-2 Omicron variant

New research suggests mutations on the receptor-binding domain of the Omicron variant exert indirect effects that reduce antibody binding to epitopes and promote immune evasion.

10 Dec 2021

Research suggests targeting fusion peptide-calcium interaction may help treat COVID-19

Researchers discovered that the entry of coronaviruses is a Ca2+-dependent process and focused their studies on the SARS-1 FP-Ca2+ interaction and its effect on membranes using electron spin resonance (ESR).

10 Dec 2021

Neutralizing antibody response against SARS-CoV-2 variants in health care workers pre- and post-vaccination

Researchers examined neutralizing antibody levels in 48 vaccinated health care workers against the major SARS-CoV-2 variants.

10 Dec 2021

Researchers recapitulate the human form of arrhythmogenic cardiomyopathy in zebrafish model

The research groups of Jeroen Bakkers (Hubrecht Institute/UMC Utrecht) and Toon van Veen (UMC Utrecht) bring forward the first patient-specific model for the heart disease arrhythmogenic cardiomyopathy (ACM).

9 Dec 2021

SARS-CoV-2 Omicron variant may bind with ACE2 receptor more efficiently

A new study discusses the effect of the Omicron variant’s mutations on its binding efficiency to the ACE2 receptor.

9 Dec 2021

Characterization of SARS-CoV-2 spike protein mutation with no associated increase in epidemiological fitness

Researchers from the Centro de Investigaciones Biológicas Margarita Salas have been investigating one of the mutations that typically appear in the Delta variant.

9 Dec 2021

Evolution of the SARS-CoV-2 omicron variant

Study shows that the omicron variant shares a common ancestry with the VOI lambda and has evolved mainly because of non-synonymous mutations.

9 Dec 2021

Study reveals the role of intracellular receptor PQBP1 in response to Tau protein

Just as a home security system can alert a homeowner to the presence of an intruder, a protein called polyglutamine binding protein-1 (PQBP1) found in brain cells can alert the body to the presence of "intruding" viruses like human immunodeficiency virus (HIV).

9 Dec 2021

Gene therapy and diabetes drug may be treatments for late-onset retinal degeneration

Scientists have discovered that gene therapy and the diabetes drug metformin may be potential treatments for late-onset retinal degeneration (L-ORD), a rare, blinding eye disease.

9 Dec 2021

Effect of SARS-CoV-2 variant emergence on efficacy of neutralizing antibodies and vaccines

A review article focuses on the efficacy of neutralizing antibodies and vaccines against the SARS-CoV-2 variants.

9 Dec 2021

Sugar-binding pockets in N-terminal domain may increase SARS-CoV-2 infectivity

The N-terminal domain has a fold that can bind sugar, and new research led by Jonathan Lees from Oxford Brookes University found the sugar-binding pockets near the N-terminal domain help to increase viral infectivity. Furthermore, the findings show that the SARS-CoV-2 sugar-binding pockets are evolving with added loops observed in the pockets of new variants.

9 Dec 2021

SARS-CoV-2 variants are evolving new ways to evade antibodies and vaccines

Continued replication of severe acute respiratory syndrome-associated coronavirus 2 (SARS-CoV-2) under selective pressure from natural and vaccine-induced immunity has led to the emergence of variants of concern (VOCs) with increased transmissibility or virulence.

8 Dec 2021

Mutation News and Research

Study finds mutational changes in Omicron variant likely increase transmissibility

Mutational landscape of SARS-CoV-2 Omicron variant

Research suggests targeting fusion peptide-calcium interaction may help treat COVID-19

Neutralizing antibody response against SARS-CoV-2 variants in health care workers pre- and post-vaccination

Researchers recapitulate the human form of arrhythmogenic cardiomyopathy in zebrafish model

SARS-CoV-2 Omicron variant may bind with ACE2 receptor more efficiently

Characterization of SARS-CoV-2 spike protein mutation with no associated increase in epidemiological fitness

Evolution of the SARS-CoV-2 omicron variant

Study reveals the role of intracellular receptor PQBP1 in response to Tau protein

Gene therapy and diabetes drug may be treatments for late-onset retinal degeneration

Effect of SARS-CoV-2 variant emergence on efficacy of neutralizing antibodies and vaccines

Sugar-binding pockets in N-terminal domain may increase SARS-CoV-2 infectivity

SARS-CoV-2 variants are evolving new ways to evade antibodies and vaccines

Omicron binds to ACE2 with high affinity, enhancing its transmissibility and infectivity

Researchers identify a molecular culprit for COVID-19's seasonal nature

Earlier screening for rare genetic mutation could lead to faster treatment for heart failure in Black Americans

Optimizing the treatment of epilepsy patients

Quantum mechanical characterization of SARS-CoV-2 Omicron variant interaction with human ACE2 receptor

Computational comparison of SARS-CoV-2 Delta and Omicron variant binding affinity with ACE2

ORF10 protein mutations alter SARS-CoV-2 pathogenicity

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Latest News