Insulin Resistance News and Research

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Insulin Resistance is a condition in which the body does not respond to insulin properly. This is most common in Type II diabetes or associated with obesity, ketoacidosis, infection, and certain rare conditions. Diminished effectiveness of insulin in lowering blood glucose levels requiring 200 units or more of insulin per day to prevent hyperglycemia or ketosis.

Fat mice gain protection against diabetes

The world's fattest mice can overeat without developing insulin resistance or diabetes thanks to a glut of a key hormone, a dichotomy that helps explain why not all obese people are diabetic, a UT Southwestern Medical Center researcher has found.

24 Aug 2007

Cytokines shown to be a cause of type 2 diabetes

In the first large scale, multiethnic study of its kind, researchers at UCLA have confirmed the role played by three particular molecules known as cytokines as a cause of Type 2 diabetes, and further, have identified these molecules as early biological markers that may be used to more accurately predict future incidences of diabetes among apparently healthy individuals.

16 Aug 2007

Diabetes increases risk of death for patients with acute coronary syndromes

Individuals with diabetes and acute coronary syndromes (ACS) such as a heart attack or unstable angina have an increased risk of death at 30 days and one year after ACS, compared with ACS patients without diabetes, according to a study in the August 15 issue of JAMA .

16 Aug 2007

The role of estrogens and polyphenols in hypertension and diabetes

Menopausal women are at relatively high risk for memory loss, high blood pressure (hypertension) and diabetes.

12 Aug 2007

Insulin Resistance Syndrome could be key to preventing cardiovascular disease, cancer, diabetes and Alzheimer's

New and important evidence shows that Insulin Resistance Syndrome can lead to elevated risk for cardiovascular disease, breathing and sleep disorders, liver disease, Polycystic Ovarian Syndrome, type 2 diabetes, certain cancers, Alzheimer's Disease and more.

3 Aug 2007

Reducing inflammation plays key role in type 1 diabetes therapy

Researchers at Beth Israel Deaconess Medical Center (BIDMC) have found that a triple combination therapy consisting of both tolerance-inducing and anti-inflammatory properties is successful in abolishing adverse autoimmunity against insulin-producing cells in a mouse model of Type 1 diabetes.

1 Aug 2007

Trans fats offer a double whammy

Along with the knowledge that 'trans fats' are particularly bad because they clog up arteries and increase the risk of heart attacks comes new information which makes them even more undesirable.

31 Jul 2007

Takeda responds to FDA recommendation on Actos

Following a joint meeting today of the U.S. Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee and the Drug Safety and Risk Management Advisory Committee, Takeda Global Research & Development (TGRD) underscores its position that ACTOS(R) (pioglitazone HCl) offers a proven safety profile regarding the risk of cardiovascular disease.

30 Jul 2007

Merck appoints David Kelley, M.D., to key role in growing Diabetes and Obesity franchise

Merck & Co., Inc. has announced that David E. Kelley, M.D., has been named vice president, franchise integrator for Diabetes & Obesity. Dr. Kelley joins Merck after 20 years on staff at the University of Pittsburgh, where he most recently served as professor of medicine and director of the Obesity & Nutrition Research Center.

24 Jul 2007

Don't drink the fizzy stuff!

Drinking more than one soft drink daily whether it's regular or diet may be associated with an increase in the risk factors for heart disease, Framingham researchers reported in Circulation: Journal of the American Heart Association.

24 Jul 2007

Cut out the sodas - cut down the metabolic syndrome risk!

According to a large U.S. study, soda drinks, whether they be diet or regular, are linked to an increased risk of metabolic syndrome among middle-age adults.

23 Jul 2007

Reducing insulin signaling in the brain can prolong lifespan

One route to a long and healthy life may be establishing the right balance in insulin signaling between the brain and the rest of the body, according to new research from Children's Hospital Boston.

20 Jul 2007

Cholesteryl ester transfer protein may also influence how fat cells store fat

Scientists have shown for the first time that a protein involved in the transfer of fat in the blood may also influence how fat cells store fat.

20 Jul 2007

Eat a good diet and exercise to live longer

The traditional prescriptions for a healthy life sensible diet, exercise and weight control extend life by reducing signaling through a specific pathway in the brain, according to Howard Hughes Medical Institute researchers who discovered the connection while studying long-lived mice.

20 Jul 2007

Elevated nonfasting triglyceride levels associated with heart attack

Results from two studies indicate that elevated nonfasting triglyceride levels are associated with cardiovascular events such as a heart attack, with one study finding that triglyceride levels measured after fasting does not show this association, according to studies in the July 18 issue of JAMA .

18 Jul 2007

Insulin resistance in skeletal muscle can be countered through exercise

Abdominal fat, the spare tire that many of us carry, has long been implicated as a primary suspect in causing the metabolic syndrome, a cluster of conditions that includes the most dangerous heart attack risk factors: prediabetes, diabetes, high blood pressure, and changes in cholesterol.

17 Jul 2007

Turn back the clock and drink a pint of milk a day for health!

A pint of milk a day could be back in fashion again following the results of a new study which says dairy foods can protect against metabolic syndrome.

12 Jul 2007

Adiponectin serves as energy-conserving signal to the brain

A fat-derived protein known for its effects on the liver and skeletal muscle might also serve as an energy-conserving signal to the brain during periods of starvation, suggests a new study in the July issue of Cell Metabolism, a publication of Cell Press.

11 Jul 2007

Rimonabant may prevent and treat obesity-related liver disease

A new study on the effect of the anti-obesity drug rimonabant on liver function in obese rats found that it reduced markers of liver damage, decreased levels of pro-inflammatory proteins, and improved lipid profiles.

4 Jul 2007

Hyperglycemia and adverse pregnancy outcome study (HAPO)

Gestational diabetes may place a much higher percentage of pregnant women -- and their unborn babies -- at risk for adverse outcomes than previously believed, according to a major international study presented at the American Diabetes Association's 67th Annual Scientific Sessions.

23 Jun 2007