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SARS-CoV-2 B.1.617 mutations L452 and E484Q do not work together to evade antibodies

A short report recently published in the Journal of Infectious Diseases demonstrates how spike mutations L452R and E484Q found in the variant B.1.617.1 of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) each confer modestly diminished sensitivity to Pfizer-BioNTech (BNT162b2) mRNA vaccine-elicited antibodies – with combined mutations having a similar impact as either one of them alone.

19 Jul 2021

Evaluation of a synthetic DNA SARS-CoV-2 vaccine INO-4800 using a nonhuman primate model

A new study published in Vaccine assesses the safety and efficacy of the synthetic DNA vaccine candidate INO-4800, delivered as a single or double dose regime.

18 Jul 2021

Wildfire smoke may greatly increase susceptibility to COVID-19

Wildfire smoke may greatly increase susceptibility to SARS-CoV-2, the virus that causes COVID-19, according to new research from the Center for Genomic Medicine at the Desert Research Institute (DRI), Washoe County Health District (WCHD), and Renown Health (Renown) in Reno, Nev.

16 Jul 2021

Sophisticated stem cell model reveals potential route of SARS-CoV-2 entry into the brain

Researchers at University of California San Diego School of Medicine and Rady Children's Institute for Genomic Medicine have produced a stem cell model that demonstrates a potential route of entry of SARS-CoV-2, the virus that causes COVID-19, into the human brain.

16 Jul 2021

Researchers isolate human monoclonal antibodies that may neutralize several norovirus variants

Researchers at Vanderbilt University Medical Center and the Baylor College of Medicine in Houston, Texas, have taken a big step toward developing targeted treatments and vaccines against a family of viruses that attacks the gastrointestinal tract.

16 Jul 2021

Broad-spectrum antibiotic no more effective than placebo in preventing COVID-19 symptoms

A UC San Francisco study has found that the antibiotic azithromycin was no more effective than a placebo in preventing symptoms of COVID-19 among non-hospitalized patients, and may increase their chance of hospitalization, despite widespread prescription of the antibiotic for the disease.

16 Jul 2021

UCSF researchers discover how the immune system may play a role in miscarriage

Researchers at UC San Francisco are zeroing in on how the immune system may play a role in miscarriage, which affects about a quarter of pregnancies.

16 Jul 2021

Study provides insights into vaccine acceptance and hesitancy in low- and-middle income countries

New research published in Nature Medicine reveals willingness to get a COVID-19 vaccine was considerably higher in developing countries (80% of respondents) than in the United States (65%) and Russia (30%).

16 Jul 2021

Pandemic disrupted the utilization of women’s preventive health services

The COVID-19 pandemic knocked many women off schedule for important health appointments, a new study finds, and many didn't get back on schedule even after clinics reopened. The effect may have been greatest in areas where such care is already likely falling behind experts' recommendations.

16 Jul 2021

Gene therapy delivered into the brain may be safe, effective in treating rare neurological disorder

A new study published in Nature Communications suggests that gene therapy delivered into the brain may be safe and effective in treating aromatic L-amino acid decarboxylase (AADC) deficiency.

16 Jul 2021

Psychiatric patients have higher odds of hospitalization and death following COVID-19

In the largest systematic review and meta-analysis to date on COVID-19 outcomes in individuals with psychiatric disorders, the odds of dying or being hospitalized following COVID-19 infection were determined to be twice as high in comparison to persons without mental disorders.

16 Jul 2021

Messenger RNA vaccines against COVID-19 not found in breast milk

Messenger RNA vaccines against COVID-19 were not detected in human milk, according to a small study by UC San Francisco, providing early evidence that the vaccine mRNA is not transferred to the infant.

16 Jul 2021

Disruption in blood clotting and the first line immune system could contribute to psychosis

A scientific review has found evidence that a disruption in blood clotting and the first line immune system could be contributing factors in the development of psychosis.

16 Jul 2021

Study uncovers how force dynamics affect cells and living tissues

Researchers, led by Pere Roca-Cusachs at the Institute for Bioengineering of Catalonia (IBEC) discover how force dynamics affect cells, and living tissues. The results give an insight into the critical mechanical processes that occur in different diseases such as cancer.

16 Jul 2021

Transient chromosomal errors can spur the formation of tumors, study finds

A Ludwig Cancer Research study has found that inducing random chromosome instability (CIN) events in mice for as little as one week is enough to trigger harmful chromosomal patterns in cells that spur the formation of tumors.

16 Jul 2021

Taking "z-drugs" with opioids increases risk of death

A new study by Vanderbilt University Medical Center researchers of more the 400,000 Medicare patients taking medications for insomnia found that the risk of death is increased when either benzodiazepines or "z-drugs" are taken with opioids.

16 Jul 2021

Novel two-component intervention may help prevent unintended pregnancy among women using opioids

Increases in maternal opioid use have led to an almost doubling in the number of babies born with neonatal abstinence syndrome (NAS) in the U.S. in the past 10 years.

16 Jul 2021

Combination of investigational therapeutic and chemotherapy shows promise for AML treatment

The investigational therapeutic ficlatuzumab in combination with chemotherapy showed signs of clinical efficacy in patients with relapsed/refractory acute myeloid leukemia.

16 Jul 2021

Hospital ‘trauma centers’ charge enormous fees to treat minor injuries and send people home

The care was ordinary. A hospital in Modesto, California, treated a 30-year-old man for shoulder and back pain after a car accident. He went home in less than three hours.

16 Jul 2021

Moderna SARS-CoV-2 vaccine highly effective against alpha and beta variants

The Moderna SARS-CoV-2 vaccine was widely distributed and had a reported efficacy in clinical trials of 94.1% against the wildtype SARS-CoV-2 following the second dose administration. Therefore, Chemaitelly et al. used this as an opportunity to measure the vaccine's efficacy against these variants as reported in a recent Nature Medicine paper, finding that the vaccine has good efficacy in all aspects.

16 Jul 2021

Medicine News and Research

SARS-CoV-2 B.1.617 mutations L452 and E484Q do not work together to evade antibodies

Evaluation of a synthetic DNA SARS-CoV-2 vaccine INO-4800 using a nonhuman primate model

Wildfire smoke may greatly increase susceptibility to COVID-19

Sophisticated stem cell model reveals potential route of SARS-CoV-2 entry into the brain

Researchers isolate human monoclonal antibodies that may neutralize several norovirus variants

Broad-spectrum antibiotic no more effective than placebo in preventing COVID-19 symptoms

UCSF researchers discover how the immune system may play a role in miscarriage

Study provides insights into vaccine acceptance and hesitancy in low- and-middle income countries

Pandemic disrupted the utilization of women’s preventive health services

Gene therapy delivered into the brain may be safe, effective in treating rare neurological disorder

Psychiatric patients have higher odds of hospitalization and death following COVID-19

Messenger RNA vaccines against COVID-19 not found in breast milk

Disruption in blood clotting and the first line immune system could contribute to psychosis

Study uncovers how force dynamics affect cells and living tissues

Transient chromosomal errors can spur the formation of tumors, study finds

Taking "z-drugs" with opioids increases risk of death

Novel two-component intervention may help prevent unintended pregnancy among women using opioids

Combination of investigational therapeutic and chemotherapy shows promise for AML treatment

Hospital ‘trauma centers’ charge enormous fees to treat minor injuries and send people home

Moderna SARS-CoV-2 vaccine highly effective against alpha and beta variants

Everything there is to know about biosimilars eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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