Therapy News and Research

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Uncovering the nuclear PIPn-p53 signalosome in cancer cell migration

In this review, the authors present recent findings that uncover a previously unappreciated nuclear signaling hub: the PIPn-p53 signalosome.

8 Aug 2025

Suicide-specific mobile app offers lifesaving support after psychiatric discharge

A mobile phone app designed to deliver suicide-specific therapy reduced suicidal behavior among high-risk psychiatric inpatients, according to a new study by scientists at Yale School of Medicine and The Ohio State University Wexner Medical Center and College of Medicine.

8 Aug 2025

Talking therapy shows lower effectiveness for young adults

Talking therapy offered by the NHS for people with depression or anxiety appears to be less effective for people aged 16-24 than those aged 25-65, according to a new study led by UCL researchers.

8 Aug 2025

RNA sequencing reveals molecular drivers for better regenerative therapies

Researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, have documented their use of a new RNA sequencing technology to uncover molecular drivers of cellular differentiation that could lead to better regenerative therapies.

8 Aug 2025

Study sheds light on how early brain wiring lays the foundation for attention skills

A new study by researchers at Simon Fraser University is shedding light on how the brain's wiring in early childhood lays the foundation for attention skills- a key step toward characterizing healthy developmental patterns that could help identify young children at risk for attention-related challenges like ADHD.

7 Aug 2025

Drug turns human blood into a mosquito killer

A drug that makes human blood lethal to mosquitoes also acts as a potent contact insecticide absorbed through the feet, providing a promising new approach to combating insecticide resistance.

7 Aug 2025

New antibody delivery system boosts Alzheimer's treatment in mice

A newly engineered antibody transport vehicle targeting the transferrin receptor enables enhanced delivery of anti-amyloid antibodies to the brains of mouse models of Alzheimer's disease, researchers report.

7 Aug 2025

Mechanical stretching boosts stem cell therapy for diabetic wounds

Chronic wounds, especially those caused by diabetes, are notoriously difficult to heal. These wounds are characterized by prolonged inflammation, impaired collagen production, and poor tissue regeneration.

7 Aug 2025

DKK1 identified as key driver of immune resistance in bone metastases

Many major cancers, including those of the lung, breast and prostate gland, spread to the bones as they progress.

7 Aug 2025

Exosomes play a dual role in cancer progression and immune regulation

Tiny extracellular vesicles known as exosomes are emerging as key regulators of the tumor microenvironment (TME), influencing how cancer progresses, spreads, and responds to treatment.

7 Aug 2025

Updated multidisciplinary European guidelines redefine MASLD diagnosis and treatment

The 2024 European clinical practice guidelines introduce a pivotal terminology shift, replacing NAFLD (non-alcoholic fatty liver disease) with MASLD (metabolic dysfunction-associated steatotic liver disease) and NASH with MASH (metabolic dysfunction-associated steatohepatitis).

7 Aug 2025

AI technology advances early detection of glioblastoma progression

University of Virginia School of Medicine scientists are tapping the power of artificial intelligence to enhance and accelerate treatment for glioblastoma, the deadliest brain cancer.

7 Aug 2025

Therapists recommend what patients should know before starting CBT

Of 1.7 million referrals for therapy in 2022-23, more than 1 million people dropped out before starting or during their therapy. This represents a dropout rate of over 60%.

7 Aug 2025

Suppression of cdc42 activity could be a promising therapy for nephrotic syndrome

A group led by the Department of Cell Biology at the Kidney Research Center, Niigata University revealed that elevated activity of cdc42 is a critical initiation event leading to proteinuria, and proposed that suppression of cdc42 activity could be a promising therapy for nephrotic syndrome.

6 Aug 2025

Cedars-Sinai study finds new way to combat Alzheimer’s in preclinical models

In a preclinical study, Cedars-Sinai investigators found that boosting angiotensin converting enzyme (ACE) in key immune cells called microglia in the brain helped protect the brains of specially bred laboratory mice against Alzheimer's disease.

6 Aug 2025

Innovative VR therapy helps ease anxiety in cardiovascular disease

Living with cardiovascular disease often takes a serious emotional toll - and with stress known to worsen heart health, there's growing interest in low-risk, innovative ways to help patients cope.

6 Aug 2025

Targeted microglia replacement shows promise against fatal neurodegenerative conditions

Tay-Sachs and Sandhoff diseases, genetic disorders affecting the brain, have no effective treatment and are typically fatal within the first years of life.

6 Aug 2025

Many patients with high-risk myelodysplastic syndromes do not receive guideline-recommended treatment

Most patients with high-risk myelodysplastic syndromes (MDS) do not receive guideline-recommended treatment with hypomethylating agents (HMAs), according to results published in Blood Neoplasia.

6 Aug 2025

TEER shows promising outcomes in elderly patients with atrial functional mitral regurgitation

The mitral valve controls blood flow between the heart's left atrium and ventricle. When structural changes affect the atrium or valve, it may not close fully-causing blood to leak backwards, a condition known as atrial functional mitral regurgitation (AFMR).

6 Aug 2025

Prime editing reverses symptoms of severe childhood neurological disease

Scientists use a precise form of gene editing called prime editing to correct the most common genetic mutations that cause alternating hemiplegia of childhood, a rare and severe neurological disorder that begins in infancy.

From The Jackson Labs 6 Aug 2025

Therapy News and Research

Uncovering the nuclear PIPn-p53 signalosome in cancer cell migration

Suicide-specific mobile app offers lifesaving support after psychiatric discharge

Talking therapy shows lower effectiveness for young adults

RNA sequencing reveals molecular drivers for better regenerative therapies

Study sheds light on how early brain wiring lays the foundation for attention skills

Drug turns human blood into a mosquito killer

New antibody delivery system boosts Alzheimer's treatment in mice

Mechanical stretching boosts stem cell therapy for diabetic wounds

DKK1 identified as key driver of immune resistance in bone metastases

Exosomes play a dual role in cancer progression and immune regulation

Updated multidisciplinary European guidelines redefine MASLD diagnosis and treatment

AI technology advances early detection of glioblastoma progression

Therapists recommend what patients should know before starting CBT

Suppression of cdc42 activity could be a promising therapy for nephrotic syndrome

Cedars-Sinai study finds new way to combat Alzheimer’s in preclinical models

Innovative VR therapy helps ease anxiety in cardiovascular disease

Targeted microglia replacement shows promise against fatal neurodegenerative conditions

Many patients with high-risk myelodysplastic syndromes do not receive guideline-recommended treatment

TEER shows promising outcomes in elderly patients with atrial functional mitral regurgitation

Prime editing reverses symptoms of severe childhood neurological disease

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