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Researcher hypothesizes that overnutrition could lead to loss of self-tolerance by impinging on immune regulation

Researchers explored the correlation between autoimmunity and obesity.

3 Apr 2023

New insights and emerging disease-modifying drugs for Alzheimer’s disease treatment

A recent review published in Biochemical Pharmacology summarized the ongoing research, providing insights into pathophysiology and emerging drugs for Alzheimer’s disease (AD).

31 Mar 2023

Can poor diet and lifestyle behaviors modify genomic susceptibility to impulsivity?

Researchers evaluated the effects of poor diet quality and lifestyle behaviors on modifying the genomic susceptibility to impulsivity.

30 Mar 2023

Study finds minimal impact of SARS-CoV-2 genome variability on current diagnostic molecular systems

The authors of a new study under review at the journal Scientific Reports and currently posted to the Research Square preprint* server proposed a novel analysis pipeline to help identify mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription-polymerase chain reaction (RT-PCR) primer regions.

29 Mar 2023

Despite raising LDL levels, coffee lowers systolic and diastolic blood pressure

Researchers performed a cross-sectional analysis of the general population of Hamburg City, Germany.

27 Mar 2023

Pet dogs across the USA are becoming increasingly resistant to benzimidazole treatment

In a recent study published in the journal PLOS Pathogens, researchers in the United States of America (USA) and Canada found molecular evidence that the parasitic hookworms (Ancylostoma caninum) in pet dogs across the USA are becoming increasingly resistant to benzimidazole, a broad-spectrum anthelmintic drug used for infection control.

22 Mar 2023

Fiber intake associated with lower risk of cognitive decline in old people with ApoE ε4 genotype

Fiber intake is associated with a lower risk of developing cognitive decline in those old people with the Apolipoprotein E ApoE ε4 genotype, regarded as a genetic risk factor linked to the development of Alzheimer's disease.

22 Mar 2023

Exploring airway-to-brain sensory pathways in influenza-induced illness

In a recent study published in the Nature journal, researchers assessed the role of the airway-to-brain sensory pathways in influenza-induced illness.

13 Mar 2023

Mutant mice models created for studying bipolar disorder

Bipolar disorder (BD) is a debilitating condition characterized by alternating states of depression (known as depressive episodes) and abnormal excitement or irritability (known as manic episodes).

7 Mar 2023

Gene variant found in individuals of African ancestry dramatically boosts Alzheimer's risk

Stanford Medicine scientists and their colleagues have discovered that a gene variant found almost exclusively in the genomes of individuals of African ancestry dramatically boosts Alzheimer's risk. About 4% of African Americans carry this variant.

1 Mar 2023

What is the effect of maternal circulating amino acids on offspring birthweight?

Researchers examined the effect of serum levels of 20 amino acids in a mother during pregnancy on offspring birthweight in a two-sample summary data Mendelian randomization framework.

27 Feb 2023

Research reveals regional differences in the spread of Japan's two main ancestral groups

Regional differences in the spread of Japan's two main ancestral groups have been revealed, thanks to new research at the University of Tokyo.

20 Feb 2023

Genome editing prevents hypertrophic cardiomyopathy in mice

In a recent study published in the journal PLoS Digital Health, researchers pursued one-time cures for hypertrophic cardiomyopathy (HCM). They used a previously constructed murine model of HCM, designated as R403Q-129SvEv, to evaluate two different genetic therapies, as follows:

19 Feb 2023

Genetic features of the immune system linked to a person's ability to resist new COVID-19 variants

An international team including researchers from the HSE University Faculty of Biology and Biotechnology has found a link between certain genetic features of the immune system and one's ability to effectively resist new waves of COVID-19.

16 Feb 2023

Isolation of Burkholderia thailandensis from the environment

A new study in Emerging Infectious Diseases aimed to detect and isolate B. thailandensis from water and soil samples collected from Puerto Rico between December 2018 and March 2020 as well as Texas between November 2019 to November 2020.

15 Feb 2023

Study evaluates benefits of implementing a pharmacogenetic panel before drug initiation

In a recent study published in The Lancet, researchers performed an implementation study of a 12-gene pharmacogenetic panel across seven European countries to investigate whether a gene-drug interaction guidedinteraction-guided prescribing strategy could prevent its adverse reactions.

8 Feb 2023

Characterization of Ikaros zinc finger protein 1 mutations in acute myeloid leukemia

Researchers evaluated the clinical and genetic characteristics of acute myeloid leukemia (AML) patients with a mutant Ikaros zinc finger protein 1 (IKZF1).

2 Feb 2023

Combination of multiple maps uncovers new genetic risk factor for AMD

Combining a map of gene regulatory sites with disease-associated loci has uncovered a new genetic risk factor of adult-onset macular degeneration (AMD), according to a new study publishing January 17th in the open access journal PLOS Biology by Ran Elkon and Ruth Ashery-Padan of Tel Aviv University, Israel, and colleagues.

18 Jan 2023

Dementia risk in women may be reduced by hormone replacement therapy

Women are at greater risk for dementia than men, probably because of waning estrogen levels following menopause. Estrogen is a key female hormone linked to reproductive, sexual, and neurological functions. A new study published in the journal Alzheimer's Research & Therapy examines how hormone replacement works in women with a high genetic risk for AD.

17 Jan 2023

Childhood asthma risk appears to be influenced by both the intestinal microbiome and 17q12-21 genotype

Childhood asthma is a condition that may be affected by different types of factors. These include the state of the infant's gut microbiome, environmental factors, and genetic factors. A recent study attempted to shed more light on how asthma risk is linked to a combination of these factors, some of which are modifiable.

16 Jan 2023