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Study suggests myeloid cell dysregulation is a driver of COVID-19 severity

Researchers determine the driving factors for disease severity and death due to COVID-19.

17 Jan 2022

Study shows SARS-CoV-2 prompts NLRP3 inflammasome activation through spike-ACE2 receptor interaction

New research assesses the NLR family pyrin domain containing 3 (NLRP3) inflammasome activation in response to SARS-CoV-2 and its spike protein, and the effects of this exposure in the presence of a-synuclein protein aggregate fibrils.

17 Jan 2022

Similarities and dissimilarities in immune responses and metabolism in SARS-CoV-2 and HIV-1 infections

A new study, posted to the bioRxiv* preprint server, has developed a single-cell atlas that presents the shared and distinct immune responses and metabolism following SARS-CoV-2 and HIV-1 infections.

13 Jan 2022

Role of leptin in immune modulation and pathophysiology of COVID-19

A recent review paper in the journal Frontiers in Physiology discusses the role of leptins in infection with SARS-CoV-2 that triggered the ongoing COVID-19 pandemic.

13 Jan 2022

The impact of Comirnaty vaccination on the levels of PEG specific antibodies

Researchers observe an increase in PEG antibodies following vaccination with the SARS-CoV-2 mRNA lipid nanoparticle vaccine.

12 Jan 2022

Study finds a subset of vascular macrophages to be powerful ally in the fight against atherosclerosis

A new study reveals the existence of a powerful ally in the fight against cardiovascular disease, a protective subset of vascular macrophages expressing the C-type lectin receptor CLEC4A2, a molecule which fosters "good" macrophage behavior within the vessel wall.

11 Jan 2022

Unraveling the early host-immune response to SARS-CoV-2 in mild COVID-19 infections

In a new study, researchers determined the early immune response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) during mild coronavirus disease 2019 (COVID-19) in rhesus macaques.

11 Jan 2022

Mapping peripheral blood glycoprotein profiles of COVID-19 patients

A team of researchers recently analyzed differential protein glyco-isoform distributions of symptomatic and asymptomatic coronavirus disease 2019 patients.

11 Jan 2022

Researchers investigate SARS-CoV-2 specific inflammatory response

New research can confirm that while some of the response from monocytes to SARS-CoV-2 is generic to virus infection, most of it SARS-CoV-2 specific, especially proinflammatory responses.

7 Jan 2022

Scientists unravel how LPS prevents or promotes development of allergic disease

Immunologists have long been baffled by LPS, the bacterial lipopolysaccharide that helps form the cell walls of Gram-negative bacteria.

5 Jan 2022

New approach to COVID-19 immune profiling using blood-based machine learning

A new study discusses the application of a novel deconvolution model AImmune to predict moderate and severe cases of COVID-19.

5 Dec 2021

Study explores adverse effects of SARS-CoV-2-induced antibody responses

The authors of a research paper published in the journal Frontiers in Immunology used Sandwich ELISA tests to determine the distribution of IgG sub-classes and complement activation levels in plasma from convalescent individuals.

25 Nov 2021

Study shows SARS-CoV-2 can infect and replicate in human iPSC-derived neurons

In a study recently published on the bioRxiv preprint server, researchers attempted to further increase the scope of previous studies in examining SARS-CoV-2 infection of human CNS resident cells.

22 Nov 2021

GABA secreted by B-cells blunts the body's cytotoxic T-cell-based response to tumors

A group of scientists led by researchers from the RIKEN Center for Integrative Medical Sciences have discovered that B-cells, a type of immune cell, secrete the neurotransmitter GABA, and also found that the GABA secreted by the B-cells promoted the emergence of anti-inflammatory macrophages, blunting the body's cytotoxic T-cell-based response to tumors.

21 Nov 2021

NIH study finds naturally acquired immunity is weak against SARS-CoV-2 variants

Immunity acquired after recovering from SARS-CoV-2 infection is not sufficient in protecting against reinfection from variants.

18 Nov 2021

SARS-CoV-2 infection inhibited by CCR2 signaling

A new study discusses the role of monocytes in protecting individuals from SARS-CoV-2.

15 Nov 2021

Potential therapeutic targets of hydrogen for treatment of the COVID-19

A recent article provided a review of a study led by academician Zhong Nanshan, in China, on COVID-19 treatment by inhalation of a mixed gas composed of hydrogen and oxygen.

12 Nov 2021

Evidence that mild and even asymptomatic SARS-CoV-2 infection can lead to sustained immune activation

A paper published in the open-access journal Viruses, reports on a study investigating long-term changes to soluble inflammatory factors and cellular immune phenotype and function in 22 survivors of mild SARS-CoV-2 infection. The observations were then compared to 11 individuals who had recovered from other mild respiratory infections.

10 Nov 2021

Mechanism of SARS-CoV-2 antibody transfer into breastmilk

A recent study aimed to understand better the mechanism of antibody transfer to breastmilk in the setting of SARS-CoV-2 infection.

10 Nov 2021

Investigation of Budesonide's mechanism of action against SARS-CoV-2

Researchers look to gain an understanding of the mechanism of action of budesonide in improving the prognosis of patients with SARS-CoV-2 infection.

1 Nov 2021

Monocyte News and Research

Study suggests myeloid cell dysregulation is a driver of COVID-19 severity

Study shows SARS-CoV-2 prompts NLRP3 inflammasome activation through spike-ACE2 receptor interaction

Similarities and dissimilarities in immune responses and metabolism in SARS-CoV-2 and HIV-1 infections

Role of leptin in immune modulation and pathophysiology of COVID-19

The impact of Comirnaty vaccination on the levels of PEG specific antibodies

Study finds a subset of vascular macrophages to be powerful ally in the fight against atherosclerosis

Unraveling the early host-immune response to SARS-CoV-2 in mild COVID-19 infections

Mapping peripheral blood glycoprotein profiles of COVID-19 patients

Researchers investigate SARS-CoV-2 specific inflammatory response

Scientists unravel how LPS prevents or promotes development of allergic disease

New approach to COVID-19 immune profiling using blood-based machine learning

Study explores adverse effects of SARS-CoV-2-induced antibody responses

Study shows SARS-CoV-2 can infect and replicate in human iPSC-derived neurons

GABA secreted by B-cells blunts the body's cytotoxic T-cell-based response to tumors

NIH study finds naturally acquired immunity is weak against SARS-CoV-2 variants

SARS-CoV-2 infection inhibited by CCR2 signaling

Potential therapeutic targets of hydrogen for treatment of the COVID-19

Evidence that mild and even asymptomatic SARS-CoV-2 infection can lead to sustained immune activation

Mechanism of SARS-CoV-2 antibody transfer into breastmilk

Investigation of Budesonide's mechanism of action against SARS-CoV-2

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