Neurodegenerative Diseases News and Research

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GemPharmatech collaborates with MSK Cancer Center to accelerate discovery of therapeutic antibodies

GemPharmatech, a global leader in preclinical research solutions and genetically-engineered mouse models, today announced a collaboration with Memorial Sloan Kettering Cancer Center (MSK) to accelerate the discovery of new therapeutic antibodies.

23 Oct 2025

Women with isolated REM sleep behavior disorder show lesser brain atrophy than men

A large international study involving nearly 700 participants reveals that women with a precursor condition to Parkinson's disease show significantly less brain atrophy—decreased cortical thickness in the brain—than men, despite similar clinical severity.

21 Oct 2025

Study reveals protein plaques in neurodegeneration function as enzymes, breaking down ATP

A new study led by Rice University's Pernilla Wittung-Stafshede has revealed that protein clumps, or plaques that clog the brain, associated with Parkinson's disease are not merely waste; they can actively drain energy from brain cells.

21 Oct 2025

How age influences the perception of ambiguous facial expressions

Do you find it easy to perceive people you meet as happy and positive? Or are you vigilant and look for signs of dissatisfaction and anger in their facial expressions?

17 Oct 2025

New nanomanufacturing technique enhances vascular systems in artificial human tissue

When biomedical researchers need to test their latest ideas, they often turn to engineered human tissue that mimics the responses in our own bodies. It's become an important intermediary step before human clinical trials.

16 Oct 2025

Revolutionary structures show how chaperone proteins prevent diseases caused by protein misfolding

The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's Research Hospital.

15 Oct 2025

New stem cell-based strategy could enhance neuronal regeneration and neuroplasticity

The brain's mechanisms for repairing injuries caused by trauma or degenerative diseases are not yet known in detail.

14 Oct 2025

How shifting antibodies fuel aging and the new therapies aiming to slow it

This review uncovers how aging reshapes immunoglobulins, particularly IgG, IgM, and IgA, driving inflammation, cellular senescence, and tissue degeneration. By dissecting B-cell dysfunction, glycosylation changes, and Fc receptor pathways, it reveals immunoglobulins as both biomarkers and potential therapeutic targets in aging.

14 Oct 2025

Slow speech improves rhythm control in people with ALS

Speech rhythm, a key attribute of natural languages that directly influences the effectiveness and efficiency of communication, is often compromised in people with neurodegenerative diseases such as Amyotrophic Lateral Sclerosis, or ALS.

10 Oct 2025

Errors in EPG5 gene implicated in rare infant condition and adult neurodegenerative diseases

Errors in a gene known to cause a serious neurodevelopmental condition in infants are also linked to the development of Parkinson's disease in adolescence and adulthood, according to new research.

9 Oct 2025

Obesity-linked fat vesicles accelerate amyloid aggregation in Alzheimer’s disease

Researchers discuss the role of extracellular vesicles as a potential link between obesity and Alzheimer’s disease.

9 Oct 2025

Research uncovers ASPL's critical role in stress granule life cycle

Stress granules are droplet-like protein hubs that temporarily shield fragile RNA from cellular stresses such as toxins. VCP is a protein essential for breaking up stress granules and has been linked to neurodegenerative diseases.

9 Oct 2025

Nasal spray of gold nanoparticles delivers lithium directly to the brain

In the form of a 'nasal spray', tiny gold particles act as carriers, delivering a treatment directly to the brain: developed by scientists at the Università Cattolica Rome campus/Fondazione Policlinico Universitario A. Gemelli IRCCS, a new nanotechnological device for the treatment and prevention of neuropsychiatric and neurodegenerative diseases.

8 Oct 2025

COMBINEDBrain and MUSC join forces to launch pediatric CNS biorepository

COMBINEDBrain, a leader in advancing translational neuroscience research, and the Medical University of South Carolina (MUSC), one of the nation's premier academic health centers, are excited to announce a strategic partnership to establish a cutting-edge biorepository for pediatric central nervous system (CNS) tissue and biofluids.

7 Oct 2025

State-of-the-art microchips help understand how sepsis and neurodegenerative diseases damage the brain

In lieu of animal experiments, researchers from the University of Rochester are using state-of-the-art microchips with human tissue to better understand how the brain operates under healthy conditions and is damaged through neurodegenerative diseases or conditions like sepsis.

7 Oct 2025

Researchers identify a central controller of mitochondrial dynamics in disease

A key switch for cellular energy balance has been discovered in cells: it could potentially become the target of new therapies for diseases ranging from Parkinson's to rare disorders caused by defects in the cell's powerhouses, the mitochondria.

6 Oct 2025

Scientists directly visualize protein clusters linked to Parkinson’s for the first time

Scientists have, for the first time, directly visualized and quantified the protein clusters believed to trigger Parkinson's, marking a major advance in the study of the world's fastest-growing neurological disease.

2 Oct 2025

Prediabetes can go into remission without weight loss

Research shows up to 22% of prediabetic individuals achieve remission without weight loss, emphasizing metabolic health over weight loss in diabetes prevention.

2 Oct 2025

Study shows prediabetes remission does not always require weight loss

Remission of prediabetes can occur even without weight loss, protecting against type 2 diabetes in up to 22% of individuals. Metabolic improvements, healthier fat distribution, and enhanced β-cell function, not body weight change, drive this benefit.

30 Sep 2025

Tissue-mimicking hydrogels drive cell reprogramming via matrix remodeling

The mechanical properties of tissue matrix are crucial for maintaining cell health and function. With aging, tissue matrix loses its mechanical integrity and exhibits altered biophysical properties, which are closely associated with various diseases including neurodegenerative diseases and cancers.

30 Sep 2025

Neurodegenerative Diseases News and Research

GemPharmatech collaborates with MSK Cancer Center to accelerate discovery of therapeutic antibodies

Women with isolated REM sleep behavior disorder show lesser brain atrophy than men

Study reveals protein plaques in neurodegeneration function as enzymes, breaking down ATP

How age influences the perception of ambiguous facial expressions

New nanomanufacturing technique enhances vascular systems in artificial human tissue

Revolutionary structures show how chaperone proteins prevent diseases caused by protein misfolding

New stem cell-based strategy could enhance neuronal regeneration and neuroplasticity

How shifting antibodies fuel aging and the new therapies aiming to slow it

Slow speech improves rhythm control in people with ALS

Errors in EPG5 gene implicated in rare infant condition and adult neurodegenerative diseases

Obesity-linked fat vesicles accelerate amyloid aggregation in Alzheimer’s disease

Research uncovers ASPL's critical role in stress granule life cycle

Nasal spray of gold nanoparticles delivers lithium directly to the brain

COMBINEDBrain and MUSC join forces to launch pediatric CNS biorepository

State-of-the-art microchips help understand how sepsis and neurodegenerative diseases damage the brain

Researchers identify a central controller of mitochondrial dynamics in disease

Scientists directly visualize protein clusters linked to Parkinson’s for the first time

Prediabetes can go into remission without weight loss

Study shows prediabetes remission does not always require weight loss

Tissue-mimicking hydrogels drive cell reprogramming via matrix remodeling

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