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Novel cryo-EM findings could revolutionize T cell immunotherapy design

One of the most exciting advances in cancer treatments in the past decade is the development of T cell immunotherapies, in which a patient's own immune system is trained to recognize and attack dangerous cells. Yet a full understanding of how they actually work has eluded researchers.

16 Dec 2025

Hydrogel-based treatment achieves innervation and pulp-dentin regeneration

The dental pulp is susceptible to microbial infection, which often results in inflammation, necrosis, and defects in the pulp-dentin complex. Traditional treatment strategies suffer from multiple limitations and do not promote neural regeneration.

16 Dec 2025

New in vitro platform predicts drug toxicity, improving cancer treatment safety

Overcoming acquired treatment resistance is one of the major challenges in the fight against cancer. While combination therapies hold promise, their toxicity to healthy tissue remains a major hurdle. To anticipate these risks, researchers at the University of Geneva (UNIGE) have developed in vitro models of the kidneys, liver, and heart - three organs particularly sensitive to such therapies.

16 Dec 2025

Scientists map how cinnamon’s bioactives interact with cancer signaling

This review synthesizes preclinical evidence showing that cinnamon-derived compounds can modulate inflammation, oxidative stress, apoptosis, and angiogenesis through multiple cancer-related signaling pathways. While biologically plausible, the findings are largely limited to cell and animal models, underscoring the need for pharmacokinetic, safety, and clinical validation.

15 Dec 2025

Circadian control of neutrophils limits heart damage after myocardial infarction

Neutrophils cause time-of-day–dependent collateral tissue damage after sterile injury through an intrinsic circadian program. Activating a CXCL12–CXCR4 checkpoint repositions neutrophils, limiting inflammatory injury without impairing antimicrobial defense.

15 Dec 2025

Two compounds sourced from cannabis show promising anti-cancer effects

In the future, scientists could use drugs made from cannabis to fight ovarian cancer. A team of scientists testing the effects of two chemical compounds sourced from cannabis on ovarian cancer cells have found that both show promising anti-cancer effects.

15 Dec 2025

Glycation stress drives aortic stiffening through oxidative stress and senescence

A new research paper was published in Volume 17, Issue 11 of Aging-US on November 14, 2025, titled "Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence."

12 Dec 2025

Novel nanomedicine mPEG@ELA-11 shows potential in treating atherosclerosis

A pioneering study led by researchers from Tongji University School of Medicine, Shanghai Jiao Tong University School of Medicine and Naval Medical University has unveiled a novel nanomedicine, mPEG@ELA-11, which demonstrates significant potential in treating atherosclerosis (AS), a leading cause of cardiovascular diseases globally.

12 Dec 2025

Exclusive licensing agreement accelerates PHD inhibitor development for anemia in CKD patients

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, and TaiGen Biotechnology, a listed discovery-based and market-focused pharmaceutical company, as well as TaiGen Biopharmaceuticals, its wholly-owned Beijing subsidiary (both referred to as "TaiGen"), today announced an exclusive pipeline out-licensing collaboration.

12 Dec 2025

AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

Insilico Medicine has developed a new class of small molecule inhibitors targeting diacylglycerol kinase alpha (DGKα) designed to restore T cell function and overcome resistance to immune checkpoint blockades in solid cancers.

12 Dec 2025

New findings show why the human intestine uniquely presents gluten to T cells

Human intestinal M cells function as dendritic cell-like antigen-presenting cells, displaying constitutive MHC-II activity and specialized machinery for processing gluten. Their ability to deamidate and present gliadin peptides positions them as key initiators of immune responses relevant to coeliac disease.

11 Dec 2025

How specific foods reshape oxidative stress responses during and after high-intensity training

Carbohydrate-rich foods blunt acute oxidative stress during fasted high-intensity exercise, while polyphenol-rich foods accelerate early recovery by reducing post-exercise ROS. Findings highlight how nutrient timing shapes redox responses in sedentary young women undergoing resistance-circuit HIIT.

11 Dec 2025

Optogenetic tool helps decipher mechanisms of brain dysfunction in Huntington’s disease

Synaptic plasticity — the brain's ability to modify the connections between neurons to support learning — is one of the neural functions profoundly altered in Huntington's disease, with a direct impact on brain function.

10 Dec 2025

Nanoflower-treated stem cells deliver healthier mitochondria to stressed cells

This study shows that vacancy-engineered MoS₂ nanoflowers drive mitochondrial biogenesis in human mesenchymal stem cells by activating SIRT1–PGC-1α signaling and reducing oxidative stress. These treated cells transfer more functional mitochondria to injured recipient cells, restoring energy metabolism and redox balance in multiple in vitro models.

9 Dec 2025

Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a small molecule that can inhibit a cancer-driving protein long considered impossible to target with drugs - a discovery that could open the door to a new class of treatments for leukemia and other hard-to-treat cancers.

9 Dec 2025

Everyday PFAS exposure alters placental function in early pregnancy

This study measured real-life PFAS concentrations in first-trimester human placentas and used these data to create a pregnancy-relevant PFAS mixture. In 3D trophoblast spheroid models, the mixture altered invasion, hormone secretion, and gene expression without broadly reducing viability at environmentally relevant doses.

8 Dec 2025

Industrial and farm chemicals quietly alter the balance of gut microbes

This study systematically screened over 1,000 agricultural and industrial chemicals and found that many can inhibit human gut bacteria in vitro. Beyond antimicrobial effects, these chemicals act as selective pressures that can reshape microbial competition, tolerance mechanisms, and metabolic pathways.

8 Dec 2025

Understanding how adult brains adapt to challenge and change

In a revelatory Genomic Press Interview published today in Brain Medicine, Dr. Paul Lucassen, full professor at the University of Amsterdam and leader of the Brain Plasticity group, shares his scientific journey that helped transform our understanding of how adult brains adapt to challenge and change.

4 Dec 2025

Insect flour could boost gut health and cut environmental impact

Chitin-rich insect flours show promise as functional foods, boosting beneficial gut bacteria while addressing allergenicity and consumer trust issues.

3 Dec 2025

AR3-based optogenetic strategy shows high efficacy in inducing apoptosis and antitumor effects

One of the hallmarks of cancer cells is their ability to evade apoptosis, or programmed cell death, through changes in protein expression.

2 Dec 2025

in vivo News and Research

Novel cryo-EM findings could revolutionize T cell immunotherapy design

Hydrogel-based treatment achieves innervation and pulp-dentin regeneration

New in vitro platform predicts drug toxicity, improving cancer treatment safety

Scientists map how cinnamon’s bioactives interact with cancer signaling

Circadian control of neutrophils limits heart damage after myocardial infarction

Two compounds sourced from cannabis show promising anti-cancer effects

Glycation stress drives aortic stiffening through oxidative stress and senescence

Novel nanomedicine mPEG@ELA-11 shows potential in treating atherosclerosis

Exclusive licensing agreement accelerates PHD inhibitor development for anemia in CKD patients

AI-guided discovery of selective DGKα inhibitors to overcome checkpoint resistance in solid cancers

New findings show why the human intestine uniquely presents gluten to T cells

How specific foods reshape oxidative stress responses during and after high-intensity training

Optogenetic tool helps decipher mechanisms of brain dysfunction in Huntington’s disease

Nanoflower-treated stem cells deliver healthier mitochondria to stressed cells

Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers

Everyday PFAS exposure alters placental function in early pregnancy

Industrial and farm chemicals quietly alter the balance of gut microbes

Understanding how adult brains adapt to challenge and change

Insect flour could boost gut health and cut environmental impact

AR3-based optogenetic strategy shows high efficacy in inducing apoptosis and antitumor effects

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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