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A high-throughput pipeline for identifying nanobodies that target and neutralize SARS-CoV-2

Researchers in the United States have developed a cost-effective, high-throughput pipeline for identifying effective nanobodies that target and neutralize severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

26 Oct 2021

High and increasing SARS-CoV-2 infection prevalence amongst school-aged children in England

The latest round of the REACT-1 study indicates SARS-CoV-2 continues to spread among children.

26 Oct 2021

N501Y mutation in SARS-CoV-2 Delta variant is key to breakthrough infections

A study in the Philadelphia area found that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants evolve to become more contagious and resistant to COVID-19 vaccines. In addition, depending on the sublineage, SARS-CoV-2 variants such as the Delta variant led to a three-fold increased risk for vaccine breakthrough cases.

25 Oct 2021

A new vaccine approach that could prevent future pandemics

News-Medical speaks to Professor Tomohiro Kurosaki about how he has developed a new vaccine approach that could prevent future pandemics.

25 Oct 2021

Immune evasion by SARS-CoV-2 facilitated by a mutational hotspot in the NTD

Researchers discuss mutations in the NTD of the spike protein, which contains an antigenic “supersite” and is the target for nAbs.

24 Oct 2021

Replication of SARS-CoV-2 variants in different cell and organ models

In this study, the replication of B.1.1.7 viruses was analyzed in different cell and organ models and dwarf hamsters.

22 Oct 2021

Development of a safe and effective COVID-19 nanoparticle vaccine

Researchers from ReVacc scientific have attempted to demonstrate the effectiveness of a new vaccine, REVC-128, two weeks post-administration.

22 Oct 2021

Hydrogel-based vaccine delivery system evokes antibody response against SARS-CoV-2

Researchers from Stanford University have been attempting to create a hydrogel-based vaccine delivery system that could improve the immune response's strength and duration.

22 Oct 2021

Improper Z-RNA recognition contributes to pathogenesis of Aicardi-Goutières syndrome

Like DNA, RNA molecules contain information through unique combinations of four different nucleotides. However, through a molecular process called RNA editing, chemical changes can be made to adenosine nucleotides that convert them to a nucleotide called inosine by enzymes known as adenosine deaminases (ADARs).

21 Oct 2021

Underexpression of specific metabolic enzyme is a common feature in kidney cancer, study shows

A team of investigators has discovered that the underexpression of a specific metabolic enzyme is a common and adverse epigenetic modulating feature in clear cell renal cell carcinoma (ccRCC), according to a recent study published in Proceedings of the National Academy of Sciences.

20 Oct 2021

UVA researchers identify an unknown trigger for epilepsy seizures

Researchers at the University of Virginia School of Medicine have uncovered how problems in cortical microcircuits in the brain can trigger epilepsy seizures.

20 Oct 2021

The effect of a SARS-CoV-2 delta variant mutation associated with higher viral loads

A new study has focused on the effect of a deletion found in the genome of the SARS-CoV-2 Delta variant that has severely reduced the amplification of ARTIC V3 amplicon 72.

20 Oct 2021

Researchers identify new gene variants that may cause inherited retinal dystrophies

An international team of researchers, led by scientists at University of California San Diego and Shiley Eye Institute at UC San Diego Health, has broadened and deepened understanding of how inherited retinal dystrophies (IRDs) affect different populations of people and, in the process, have identified new gene variants that may cause the diseases.

20 Oct 2021

SARS-CoV-2 mutations amplify its advantage over host for efficient translation of viral RNAs

A study shows that mutations that SARS-CoV-2 has gained improve its advantage in the efficient translation of viral RNAs.

19 Oct 2021

Researchers reveal the mechanism of artificial chromosome formation in C. elegans' embryos

A research team led by Dr Karen Wing Yee YUEN, Associate Professor from the School of Biological Sciences at the University of Hong Kong (HKU), revealed the mechanism of artificial chromosome (AC) formation in the embryos of the model organism Caenorhabditis elegans, a 1-mm long, transparent nematode.

18 Oct 2021

Famous scientist joins NYU Langone’s Division of Rheumatology

Nationally recognized for his work studying a novel inflammatory disorder known as VEXAS, David B. Beck, MD, PhD, has joined the Division of Rheumatology at NYU Langone.

18 Oct 2021

Study provides the most detailed analysis of England's SARS-CoV-2 genomic surveillance information

The Covid-19 crisis that gripped the UK between September 2020 and June 2021 can be thought of as a series of overlapping epidemics, rather than a single event, say researchers at the Wellcome Sanger Institute, EMBL's European Bioinformatics Institute (EMBL-EBI) and their collaborators.

18 Oct 2021

Researchers discover a new paradigm for how biological switches are regulated

Quantitative Biosciences Institute (QBI) researchers at UC San Francisco have discovered a new paradigm for how fundamental biological switches, proteins that can be turned on and off to control processes like cell differentiation, cell growth, and transport within a cell, are regulated at the molecular level, specifically by molecules binding at newly discovered sites far away from the main binding site, and the broader impacts these changes have on a cellular level.

18 Oct 2021

Devastating genetic disease in children may be treatable in adulthood

A devastating genetic disease called CDKL5 deficiency disorder (CDD), which strikes in early childhood, may be significantly treatable even in adulthood, a new study from the Perelman School of Medicine at the University of Pennsylvania suggests.

15 Oct 2021

Statistical study reveals constraints and directions in the evolution of protein structure, function

A recent statistical study has revealed some of the constraints and directions in the evolution of the structure and function of proteins.

15 Oct 2021

Mutation News and Research

A high-throughput pipeline for identifying nanobodies that target and neutralize SARS-CoV-2

High and increasing SARS-CoV-2 infection prevalence amongst school-aged children in England

N501Y mutation in SARS-CoV-2 Delta variant is key to breakthrough infections

A new vaccine approach that could prevent future pandemics

Immune evasion by SARS-CoV-2 facilitated by a mutational hotspot in the NTD

Replication of SARS-CoV-2 variants in different cell and organ models

Development of a safe and effective COVID-19 nanoparticle vaccine

Hydrogel-based vaccine delivery system evokes antibody response against SARS-CoV-2

Improper Z-RNA recognition contributes to pathogenesis of Aicardi-Goutières syndrome

Underexpression of specific metabolic enzyme is a common feature in kidney cancer, study shows

UVA researchers identify an unknown trigger for epilepsy seizures

The effect of a SARS-CoV-2 delta variant mutation associated with higher viral loads

Researchers identify new gene variants that may cause inherited retinal dystrophies

SARS-CoV-2 mutations amplify its advantage over host for efficient translation of viral RNAs

Researchers reveal the mechanism of artificial chromosome formation in C. elegans' embryos

Famous scientist joins NYU Langone’s Division of Rheumatology

Study provides the most detailed analysis of England's SARS-CoV-2 genomic surveillance information

Researchers discover a new paradigm for how biological switches are regulated

Devastating genetic disease in children may be treatable in adulthood

Statistical study reveals constraints and directions in the evolution of protein structure, function

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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