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Advances in targeting the CD47/SIRPα "do not eat me" pathway for cancer therapy

A new editorial was recently published in Oncotarget's Volume 15, on July 10, 2024, entitled, "The advances in targeting CD47/SIRPα "do not eat me" axis and their ongoing challenges as an anticancer therapy."

13 Sep 2024

Salt can boost antitumor responses of T cells

Elevated sodium levels in tumors boost T-cell metabolic fitness and cytotoxicity, revealing potential avenues for improving cancer therapies.

13 Sep 2024

The potential benefits of aged black garlic on inflammation and prostate cancer

Researchers investigate the anti-inflammatory and anti-prostate cancer properties of aged black garlic extract.

13 Sep 2024

Melanoma incidence and mortality may eventually decrease among the entire Swedish population

Researchers assess the incidence of melanoma and mortality trends among younger patients.

13 Sep 2024

Early Phase I data shows promise for mRNA cancer immunotherapy in advanced solid cancers

Interim data from the Phase I dose escalation part of the mRNA cancer immunotherapy (mRNA-4359), show promise in patients with advanced solid cancers.

12 Sep 2024

B cell abnormalities identified as potential biomarkers for triple negative breast cancer treatment response

Researchers at Baylor College of Medicine and collaborating institutions have discovered new insights into tumor-induced B cell changes in blood and bone marrow of triple negative breast cancer patients.

12 Sep 2024

Five key factors identified for predicting immunotherapy response in cancer patients

Immunotherapy has transformed cancer treatment in recent years by enabling the immune system to attack tumor cells.

12 Sep 2024

AI tool enhances cancer diagnosis by transforming standard tissue images

VirtualMultiplexer transforms histology images into detailed cancer markers, streamlining diagnostics and enhancing patient outcomes through AI innovation.

12 Sep 2024

Researchers uncover why typically normal protein drives prostate cancer

NSD-2 is crucial for AR activity in prostate cancer, promoting tumor growth and offering a potential therapeutic target for advanced prostate cancer treatment.

12 Sep 2024

Long radiotherapy course shows better organ preservation in rectal cancer

The COVID-19 pandemic has enabled researchers to show that a long course of radiotherapy given before surgery may be a better treatment for avoiding surgery, preserving the rectum and anus, and preventing regrowth of the primary tumor than a short course of radiotherapy for patients with rectal cancer – a type of bowel cancer.

11 Sep 2024

MSK researchers identify a new, rare type of small cell lung cancer

A team of doctors and researchers at Memorial Sloan Kettering Cancer Center (MSK) have identified a new, rare type of small cell lung cancer that primarily affects younger people who have never smoked.

11 Sep 2024

New algorithm unveils key genetic mutations across multiple cancers

A computer algorithm can efficiently find genetic mutations that work together to drive cancer as well as other important genetic clues that researchers might someday use to develop new treatments for a variety of cancers.

11 Sep 2024

Telisotuzumab vedotin shows promising results in asian patients with c-Met overexpressing NSCLC

The c-Met-directed antibody-drug conjugate telisotuzumab vedotin demonstrated durable responses and an acceptable safety profile in patients of Asian race with c-Met protein-overexpressing, epidermal growth factor receptor (EGFR) wildtype (WT), locally advanced/metastatic nonsquamous non-small cell lung cancer (NSCLC), according to research presented today at the International Association for the Study of Lung Cancer's 2024 World Conference on Lung Cancer.

11 Sep 2024

PDX engraftment predicts high recurrence and poor survival in triple-negative breast cancer

Researchers examine the association between patient-derived xenograft with recurrence and survival rates in triple negative breast cancer patients.

11 Sep 2024

A promising new therapeutic target for MASLD identified

Using a novel stem cell platform, a team of the Medical University of South Carolina researchers has identified a pathway that could be targeted by drugs to reduce fat accumulation in patients with a common form of fatty liver disease known as metabolic dysfunction-associated steatotic liver disease, or MASLD.

11 Sep 2024

Fibrous scars drive glioblastoma recurrence

A Ludwig Cancer Research study has discovered that recurrent tumors of the aggressive brain cancer glioblastoma multiforme (GBM) grow out of the fibrous scars of malignant predecessors destroyed by interventions such as radiotherapy, surgery, and immunotherapy.

11 Sep 2024

High linoleic acid intake during pregnancy may harm fetal growth and raise obesity risk

High maternal linoleic acid intake during pregnancy may impact fetal development and increase the risk of obesity and inflammation in offspring. However, more research is needed to fully understand these effects in humans.

10 Sep 2024

Immunotherapy before and after surgery benefits NSCLC patients

People with operable non-small cell lung cancers may fare better over the next few years by receiving immunotherapy treatments before and after surgery instead of only before surgery, according to a new analysis by Johns Hopkins Kimmel Cancer Center investigators.

9 Sep 2024

Promising pathway for predictive biomarkers in lung cancer immunotherapy revealed

A study presented today at the International Association for the Study of Lung Cancer 2024 World Conference on Lung Cancer demonstrated a promising pathway toward developing predictive biomarkers for immune checkpoint inhibitors.

9 Sep 2024

Age-related fibroblast changes in males drive aggressive melanoma

Age-related changes in the fibroblasts, cells that create the skin's structure, contribute to the development of aggressive, treatment-resistant melanoma in males, according to research in mice by the Johns Hopkins Kimmel Cancer Center.

6 Sep 2024

Tumor News and Research

Advances in targeting the CD47/SIRPα "do not eat me" pathway for cancer therapy

Salt can boost antitumor responses of T cells

The potential benefits of aged black garlic on inflammation and prostate cancer

Melanoma incidence and mortality may eventually decrease among the entire Swedish population

Early Phase I data shows promise for mRNA cancer immunotherapy in advanced solid cancers

B cell abnormalities identified as potential biomarkers for triple negative breast cancer treatment response

Five key factors identified for predicting immunotherapy response in cancer patients

AI tool enhances cancer diagnosis by transforming standard tissue images

Researchers uncover why typically normal protein drives prostate cancer

Long radiotherapy course shows better organ preservation in rectal cancer

MSK researchers identify a new, rare type of small cell lung cancer

New algorithm unveils key genetic mutations across multiple cancers

Telisotuzumab vedotin shows promising results in asian patients with c-Met overexpressing NSCLC

PDX engraftment predicts high recurrence and poor survival in triple-negative breast cancer

A promising new therapeutic target for MASLD identified

Fibrous scars drive glioblastoma recurrence

High linoleic acid intake during pregnancy may harm fetal growth and raise obesity risk

Immunotherapy before and after surgery benefits NSCLC patients

Promising pathway for predictive biomarkers in lung cancer immunotherapy revealed

Age-related fibroblast changes in males drive aggressive melanoma

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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