Immune System News and Research

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Research explains one of the fundamental mysteries of multiple sclerosis

Scientists have pinpointed a chemical messenger that frees some white blood cells from the body's normal constraints, allowing the cells to act like renegades that could damage nerves in the central nervous system. The work, to be published in the July 15 issue of the Journal of Immunology and just published on-line, helps explain one of the fundamental mysteries of multiple sclerosis (MS).

11 Jul 2005

Scientists discover how an HIV protein fragment shuts down an immune response

The HIV virus hides out in the very immune system cells that are meant to protect the body from viral infection. But how does it prevent these cells from mounting a full-scale attack against the invader?

11 Jul 2005

Researchers clarifiy role of Notch protein in T-cell development

Researchers at the University of Pennsylvania School of Medicine have recently clarified the role of the Notch protein in T-cell development. T cells are required for many aspects of immunity, including fighting viral infections, providing cancer surveillance, and regulating multiple aspects of the immune response.

6 Jul 2005

Tourette's and obsessive compulsive disorders linked to strep throat

A new study is suggesting that Strep throat infections can triple a child's risk of developing compulsive behaviors or tics, an indication that the same antibodies that attack the infection may also damage brain cells.

6 Jul 2005

Why cervical precancers disappear in some women and not in others

New research sheds light on why cervical precancers disappear in some women and not in others. Scientists at the Johns Hopkins Kimmel Cancer Center report in the July 1 issue of Clinical Cancer Research that the reason many of these lesions persist is an unlikely mix of human papilloma virus (HPV) strain and a woman's individual immune system.

6 Jul 2005

Study is the first to show that there are mechanisms in place for the immune system to identify cancer cells

A study undertaken by biologists at the University of California, Berkeley, has found that damage to a cell's DNA sets off a chain reaction that leads to the increased expression of a marker recognized by the body's immune system.

6 Jul 2005

HIF-1alpha expression regulates the bactericidal capacity of phagocytes

When microorganisms invade the body, immune mechanisms kick in to fight them off. The infected tissues typically show depleted oxygen levels, and a protein called HIF-1 alpha regulates this. Interestingly, the cells responsible for destroying the foreign pathogens are effective in this low-oxygen environment.

6 Jul 2005

Research sheds light on why cervical precancers disappear in some women and not in others

New research sheds light on why cervical precancers disappear in some women and not in others. Scientists say the reason many of these lesions persist is an unlikely mix of human papilloma virus (HPV) strain and a woman’s individual immune system.

4 Jul 2005

Researchers find enzyme vital for controlling the early stages of cell death

Researchers at UT Southwestern Medical Center have found an enzyme vital for controlling the early stages of cell death - a beneficial and normal process when it works right, but malignant in a variety of cancers when it malfunctions.

30 Jun 2005

Researchers have identified a highly specific pathway that causes inflammation in lung tissue

...a discovery that could help in the design of more targeted treatments for patients with various lung diseases, including cystic fibrosis.

30 Jun 2005

Daclizumab effective at reducing organ rejection and risk of infection in heart transplant patients

A new study shows that a drug, called daclizumab, is effective at reducing organ rejection and risk of infection in heart transplant patients. The multi-center study by cardiologists from the United States, Sweden, Germany and Canada will be published in the June 30 issue of The New England Journal of Medicine.

30 Jun 2005

Experimental drug for diabetes looks promising

Encouraging results in a small study, with a new experimental treatment, promises help for certain diabetics to retain some ability to make their own insulin.

29 Jun 2005

Grand Challenges in Global Health awards $450m to top scientists

Grants totalling U.S $450m were awarded yesterday to some of the world's most inventive scientists to enable them to turn their novel ideas into practical solutions to the 14 greatest problems plaguing human health today.

28 Jun 2005

Adult, or post-natal, stem cells have the same ability as embryonic stem cells to multiply

In a ground-breaking study, scientists at Children's Hospital of Pittsburgh have discovered that adult, or post-natal, stem cells have the same ability as embryonic stem cells to multiply, a previously unknown characteristic indicating that post-natal stem cells may play an important therapeutic role.

27 Jun 2005

Gleevec or similar drugs might be useful in preventing adverse side effects of smallpox vaccine

Mice given a relatively new cancer drug can survive an otherwise lethal dose of vaccinia virus, a relative of smallpox virus, report scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID).

27 Jun 2005

Scientists solve structure of a critical innate immune system protein

Scientists at The Scripps Research Institute have solved the structure of a crucial human immune system molecule called TLR3, an acronym for Toll-like receptor three. In an upcoming issue of the journal Science, the protein is described as a large horseshoe-shaped coil composed of 23 leucine-rich repeats (LRRs).

27 Jun 2005

Researchers successfully treat laboratory model of a lysosomal storage disease called GM1

Physicians might one day be able to treat a disease that destroys brain cells in children using genetically modified cells to transport a "drug" to the site of the dying neural cells (cells that transmit impulses).

27 Jun 2005

Scientists successfully isolate stem cells from human skin

Scientists at Wake Forest University School of Medicine have successfully isolated stem cells from human skin, expanded them in the laboratory and coaxed them into becoming fat, muscle and bone cells.

27 Jun 2005

Enzyme known as cathepsin G may be a target for anti-inflammatory treatments

The finding by researchers at Washington University School of Medicine in St. Louis shows that an enzyme known as cathepsin G regulates the ability of immune cells known as neutrophils to secrete chemicals that attract other immune cells and start the local inflammatory process. Over time, the excessive accumulation of immune cells can lead to tissue and cartilage damage in joints, causing pain and limiting mobility.

27 Jun 2005

Adult, or post-natal, stem cells have the same ability as embryonic stem cells to multiply

27 Jun 2005

Immune System News and Research

Research explains one of the fundamental mysteries of multiple sclerosis

Scientists discover how an HIV protein fragment shuts down an immune response

Researchers clarifiy role of Notch protein in T-cell development

Tourette's and obsessive compulsive disorders linked to strep throat

Why cervical precancers disappear in some women and not in others

Study is the first to show that there are mechanisms in place for the immune system to identify cancer cells

HIF-1alpha expression regulates the bactericidal capacity of phagocytes

Research sheds light on why cervical precancers disappear in some women and not in others

Researchers find enzyme vital for controlling the early stages of cell death

Researchers have identified a highly specific pathway that causes inflammation in lung tissue

Daclizumab effective at reducing organ rejection and risk of infection in heart transplant patients

Experimental drug for diabetes looks promising

Grand Challenges in Global Health awards $450m to top scientists

Adult, or post-natal, stem cells have the same ability as embryonic stem cells to multiply

Gleevec or similar drugs might be useful in preventing adverse side effects of smallpox vaccine

Scientists solve structure of a critical innate immune system protein

Researchers successfully treat laboratory model of a lysosomal storage disease called GM1

Scientists successfully isolate stem cells from human skin

Enzyme known as cathepsin G may be a target for anti-inflammatory treatments

Adult, or post-natal, stem cells have the same ability as embryonic stem cells to multiply

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