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TAU researchers identify novel genetic mutation as source of specific rare disease

Rare diseases -- those that affect fewer than one in 200,000 people -- are often identified early in life. Some 30 percent of children afflicted by these "orphan diseases" do not live to see their fifth birthday. While the U.S. Orphan Drug Act of 1983 was written into law to promote research on the topic, the cost of identifying the source and progression of these diseases remains prohibitive for many families.

10 Feb 2015

Researchers reveal how damage from obesity passes from mother to children

In a breakthrough discovery, researchers at the University of Adelaide have revealed how damage from obesity is passed from a mother to her children, and also how that damage can be reversed.

10 Feb 2015

Synthetic Biologics reports positive results from SYN-004 Phase 1b trial to prevent C. difficile infection

Synthetic Biologics, Inc., a developer of pathogen-specific therapies for serious infections and diseases, with a focus on protecting the microbiome, today announced positive topline safety and tolerability results from a Phase 1b clinical trial of SYN-004, the Company's investigational oral beta-lactamase enzyme designed to protect the microbiome and prevent Clostridium difficile (C. difficile) infection, antibiotic-associated diarrhea and secondary antibiotic-resistant infections in patients receiving intravenous (IV) beta-lactam antibiotic therapy.

10 Feb 2015

GenomeDx announces publication of positive validation study for Decipher Prostate Cancer Classifier

GenomeDx Biosciences today announced the publication of a positive validation study for the Decipher® Prostate Cancer Classifier, a genomic test for prostate cancer. The study, published in the Journal of Clinical Oncology, showed that patients with low genomic risk (as determined by Decipher) may be optimally managed with observation after radical prostatectomy (prostate surgery), while those with high genomic risk (as determined by Decipher) may be better managed earlier with adjuvant radiotherapy.

10 Feb 2015

New research provides hope for treating stroke using HUCBCs

Researchers have known that transplanted human umbilical cord cells (HUCBCs) can have a restorative effect on the brain and brain function following a stroke. However, just how the cells exert their therapeutic effects has not been clear. Now, a research team from the University of South Florida using animal models of stroke has found that the HUCBCs are most beneficial in preventing neuron loss when the Akt signaling pathway is activated by secretions from the HUCBCs and that Akt activation subsequently impacts a specific gene involved in reducing inflammation.

10 Feb 2015

Study describes novel screening system that has potential to uncover effective ovarian cancer drugs

University of Chicago Medicine researchers have built a model system that uses multiple cell types from patients to rapidly test compounds that could block the early steps in ovarian cancer metastasis. Their three-dimensional cell-culture system, adapted for high-throughput screening, has enabled them to identify small molecules that can inhibit adhesion and invasion, preventing ovarian cancers from spreading to nearby tissues.

10 Feb 2015

New model proposed for predicting outcomes more accurately in HPV-related throat cancer patients

Researchers at the Princess Margaret Cancer Centre are proposing a new model to enable doctors to predict outcomes more accurately for patients with throat cancers specifically caused by Human Papillomavirus (HPV).

10 Feb 2015

Radiation therapy more effective at preventing recurrence of ductal carcinoma in situ

In a surprising finding, a collaborative national clinical trials group (RTOG) including Dartmouth-Hitchcock's Alan Hartford, MD, PhD, discovered that radiation therapy in addition to chemotherapy was even more effective at preventing recurrence of ductal carcinoma in situ (DCIS) than previously thought.

10 Feb 2015

Researchers discover inherited genetic variations associated with treatment-related hearing loss

St. Jude Children's Research Hospital investigators have discovered inherited genetic variations that are associated with rapid hearing loss in young cancer patients treated with the drug cisplatin. The research appears in the current online issue of the scientific journal Nature Genetics.

10 Feb 2015

Combination therapies may overcome resistance to targeted cancer drugs

A protein called YAP, which drives the growth of organs during development and regulates their size in adulthood, plays a key role in the emergence of resistance to targeted cancer therapies, according to a new study led by UC San Francisco researchers.

10 Feb 2015

First patients treated with Orthocell's tendon repair therapy in Hong Kong

Regenerative medicine company Orthocell Limited has announced it has expanded its presence in Asia with the first patients treated with its world-leading tendon repair therapy in Hong Kong.

10 Feb 2015

Researchers identify immune biomarkers that could help predict complications in HIV/TB patients

Doctors treating patients battling both HIV and tuberculosis (TB)--many of whom live in Africa--are faced with the decision when to start those patients on antiretroviral therapy (ART) while they are being treated with antibiotics for active TB disease. Some patients fare well on both interventions, with the immune system in check and the TB controlled.

10 Feb 2015

Only 65% of breast cancer patients who undergo mastectomy receive postmastectomy radiation therapy

Breast cancer patients who undergo a mastectomy should receive subsequent radiation treatment if their cancer has spread to four or more nearby lymph nodes, however, according to a new study, only 65 percent of these women are getting the recommended postmastectomy radiation therapy (PMRT).

10 Feb 2015

Discovery improves understanding of factors that trigger allergic asthma

When the mucosal surfaces in the lungs of healthy people come into contact with allergenic substances, so-called regulatory T cells also known as Treg cells, are activated. These are capable of actively preventing the development of allergies.

9 Feb 2015

Hastings Center Report: Latest issues on health and medicine

For two years, a debate has raged over the study known as the Surfactant, Positive Pressure, and Oxygenation Randomized Trial (SUPPORT), which sought to gauge the risks and benefits of different blood oxygen levels currently targeted in the care of premature infants.

9 Feb 2015

Ohio State allergy specialists study, learn more about eosinophilic esophagitis

Its name is daunting. It's the hottest topic among allergy experts. It's showing up more and doctors don't yet know why. Allergy specialists at The Ohio State University Wexner Medical Center are seeing more people with eosinophilic esophagitis (EoE), an inflammatory response in the esophagus that makes it hard to swallow food.

9 Feb 2015

Researchers identify physical, cognitive signs associated with imminent death in patients with cancer

Researchers at The University of Texas MD Anderson Cancer Center have identified eight highly specific physical and cognitive signs associated with imminent death in cancer patients. The findings, published in the journal Cancer, could offer clinicians the ability to better communicate with patients and families.

9 Feb 2015

Researchers conduct environmental scan to understand physical activity services offered by FHTs

To better understand the current use of physical activity as medicine among Family Health Teams (FHTs) in Ontario, researchers at the Department of Kinesiology at the University of Waterloo and the Centre for Family Medicine Family Health Team conducted an environmental scan of 102 FHTs.

9 Feb 2015

Fungal infections rarely develop resistance to combination drug therapy

Researchers at the University of Toronto have discovered that Candida albicans -- a leading cause of potentially fatal hospital-acquired infections -- rarely develops resistance to combination drug therapy and, when it becomes resistant, it also becomes less dangerous.

9 Feb 2015

New AGA guideline provides guidance to prevent HBV reactivation

Long-term immunosuppressive therapy can cause the hepatitis B virus (HBV) to become active, even in patients who are not aware that they are infected with the virus. A new guideline from the American Gastroenterological Association provides guidance to physicians and patients who use immunosuppressive agents for the treatment of a variety of disorders, including gastrointestinal, dermatologic, neurologic and rheumatologic, among others.

9 Feb 2015

Therapy News and Research

TAU researchers identify novel genetic mutation as source of specific rare disease

Researchers reveal how damage from obesity passes from mother to children

Synthetic Biologics reports positive results from SYN-004 Phase 1b trial to prevent C. difficile infection

GenomeDx announces publication of positive validation study for Decipher Prostate Cancer Classifier

New research provides hope for treating stroke using HUCBCs

Study describes novel screening system that has potential to uncover effective ovarian cancer drugs

New model proposed for predicting outcomes more accurately in HPV-related throat cancer patients

Radiation therapy more effective at preventing recurrence of ductal carcinoma in situ

Researchers discover inherited genetic variations associated with treatment-related hearing loss

Combination therapies may overcome resistance to targeted cancer drugs

First patients treated with Orthocell's tendon repair therapy in Hong Kong

Researchers identify immune biomarkers that could help predict complications in HIV/TB patients

Only 65% of breast cancer patients who undergo mastectomy receive postmastectomy radiation therapy

Discovery improves understanding of factors that trigger allergic asthma

Hastings Center Report: Latest issues on health and medicine

Ohio State allergy specialists study, learn more about eosinophilic esophagitis

Researchers identify physical, cognitive signs associated with imminent death in patients with cancer

Researchers conduct environmental scan to understand physical activity services offered by FHTs

Fungal infections rarely develop resistance to combination drug therapy

New AGA guideline provides guidance to prevent HBV reactivation

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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