Clinical Trial News and Research

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Researchers uncover a gene that causes heart defects in Down syndrome

Researchers at the Francis Crick Institute and UCL have identified a gene that causes heart defects in Down syndrome, a condition that results from an additional copy of chromosome 21.

24 Jan 2024

European consortium awarded €6.5M to study psychedelic-assisted therapy

A European consortium of 19 partners has been awarded over €6.5M by the European Union to study psilocybin to treat psychological distress in people with progressive incurable illnesses requiring palliative care.

24 Jan 2024

Combination drug therapy beats solo treatment for aggressive prostate cancer relapse

Combining testosterone-blocking drugs in patients with prostate cancer relapse prevents the spread of cancer better than treatment with a single drug, a multi-institution, Phase 3 clinical trial led by UC San Francisco researchers has found.

23 Jan 2024

Blood pressure drug could help lower anxiety for kids and young adults with ASD

A new study at the University of Missouri's Thompson Center for Autism and Neurodevelopment found that propranolol, a medication that treats high blood pressure, can also help lower anxiety for kids and young adults with autism spectrum disorder (ASD).

23 Jan 2024

Scientists identify a new approach to treating sarcoidosis

A research team led by Georg Stary (Medical University of Vienna and CeMM) has identified a new approach to treating the inflammatory disease sarcoidosis.

23 Jan 2024

APOE4 genetic risk factors for Alzheimer's disease associated with increased risk of subclinical atherosclerosis

Scientists at the Centro Nacional de Investigaciones Cardiovasculares in Madrid have found that one of the most potent genetic risk factors for Alzheimer disease, apolipoprotein E4 (APOE4), is also associated with an increased risk of developing subclinical atherosclerosis in middle age.

23 Jan 2024

Study identifies genetic variants that influence response to preterm birth treatment

A UC San Francisco-led study has for the first time identified genetic variants that predict whether patients will respond to treatment for preterm birth, a condition that affects one in 10 infants born in the United States.

22 Jan 2024

Thinning brain tissue predicts dementia up to a decade before symptoms

A ribbon of brain tissue called cortical gray matter grows thinner in people who go on to develop dementia, and this appears to be an accurate biomarker of the disease five to 10 years before symptoms appear, researchers from The University of Texas Health Science Center at San Antonio (also called UT Health San Antonio) reported.

22 Jan 2024

Nicotine patches and e-cigarettes in pregnancy: A deep dive into risks and outcomes

Researchers examined the safety of e-cigarettes and nicotine-containing patches during pregnancy.

22 Jan 2024

Annexin-A1 targeted therapy beats several cancers

A new study published in Nature's cancer journal Oncogene highlights the effectiveness of MDX-124, the first therapeutic drug to target annexin-A1, a protein which is overexpressed in several cancer types and promotes tumour progression.

19 Jan 2024

Clinical trial shows MRI and tracking-guided delivery of magnetic stimulation to brains of people with severe depression eases symptoms

Researchers performed a randomized clinical trial to compare resting-state functional magnetic resonance imaging connectivity-guided intermittent theta burst stimulation vs. repetitive transcranial magnetic stimulation for therapy-resistant depression.

19 Jan 2024

New device rapidly provides white blood cell count with a single drop of blood

A Rutgers researcher, through his spinoff company, has led a team to design and test a device that quickly counts a person's white blood cells with a single drop of blood, similar to the way glucometers rapidly scan for blood sugar levels.

18 Jan 2024

Play to prevent: Video games for preventing falls in community-dwelling older people

Researchers evaluated the effectiveness of home-based cognitive and exergame step training interventions compared with a control group in preventing falls among community-dwelling older adults.

18 Jan 2024

Combined cardio and strength workout effective against cardiovascular disease

Approximately one in three deaths in the U.S. is caused by cardiovascular disease, according to the U.S. Centers for Disease Control and Prevention. A robust body of evidence shows aerobic exercise can reduce risks, especially for people who are overweight or obese.

17 Jan 2024

Decoding blood cancer secrets to optimize CAR T therapy

Chimeric antigen receptor T-cell therapy, or CAR T, has dramatically improved the treatment of certain blood cancers. Initially approved for patients who had failed multiple lines of therapy, clinical trials have shown CAR T can be used as an earlier treatment option.

17 Jan 2024

Phase 3 trial shows acoramidis safe and effective for transthyretin amyloid cardiomyopathy

Pumping over 100,000 times a day, the heart is a critical muscle needed to deliver oxygen and nutrients to our organs to sustain healthy bodily function.

16 Jan 2024

Vanderbilt launches $13 million trial to test repurposed drugs for Rett syndrome

Vanderbilt University Medical Center received a $13 million Department of Defense grant to lead a multisite clinical trial that will evaluate repurposed FDA-approved drugs as treatment options for patients with Rett syndrome.

16 Jan 2024

New strategy makes palliative care more accessible to patients with chronic illnesses

Ordering a palliative care consultation by "default" – via an automatic order programmed into the electronic medical record that doctors may cancel if they choose – is an effective strategy to give more hospitalized patients the opportunity to benefit from palliative care, and sooner, according to a new study led by researchers from the Perelman School of Medicine at the University of Pennsylvania.

16 Jan 2024

Exposure to AI models may reshape clinician's decisions and improve care outcomes

What if just observing Artificial Intelligence (AI) could make a clinician more efficient at their job and improve care outcomes for patients?

16 Jan 2024

Contact lenses monitor eye pressure for glaucoma prevention

Glaucoma effects around 70 million people worldwide and can cause irreversible loss of vision if not treated – but around half of those living with the condition are not aware of it.

16 Jan 2024

Clinical Trial News and Research

Researchers uncover a gene that causes heart defects in Down syndrome

European consortium awarded €6.5M to study psychedelic-assisted therapy

Combination drug therapy beats solo treatment for aggressive prostate cancer relapse

Blood pressure drug could help lower anxiety for kids and young adults with ASD

Scientists identify a new approach to treating sarcoidosis

APOE4 genetic risk factors for Alzheimer's disease associated with increased risk of subclinical atherosclerosis

Study identifies genetic variants that influence response to preterm birth treatment

Thinning brain tissue predicts dementia up to a decade before symptoms

Nicotine patches and e-cigarettes in pregnancy: A deep dive into risks and outcomes

Annexin-A1 targeted therapy beats several cancers

Clinical trial shows MRI and tracking-guided delivery of magnetic stimulation to brains of people with severe depression eases symptoms

New device rapidly provides white blood cell count with a single drop of blood

Play to prevent: Video games for preventing falls in community-dwelling older people

Combined cardio and strength workout effective against cardiovascular disease

Decoding blood cancer secrets to optimize CAR T therapy

Phase 3 trial shows acoramidis safe and effective for transthyretin amyloid cardiomyopathy

Vanderbilt launches $13 million trial to test repurposed drugs for Rett syndrome

New strategy makes palliative care more accessible to patients with chronic illnesses

Exposure to AI models may reshape clinician's decisions and improve care outcomes

Contact lenses monitor eye pressure for glaucoma prevention

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