Gene Expression News and Research

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Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. Gene expression may be measured by looking at the RNA, or the protein made from the RNA, or what the protein does in a cell.

New study will help investigate innate immune responses to viral infections

Researchers from Boston University School of Medicine (BUSM) report the formation of human cells containing a green fluorescent protein or GFP (one of the most important proteins in biology and fluorescence imaging) genetically fused with two interferon stimulated genes (ISGs), namely Viperin and ISG15.

19 May 2021

A promising drug delivery system for therapeutics that shut down harmful genes

Viruses attack the body by sending their genetic code -- DNA and RNA -- into cells and multiplying. A promising class of therapeutics that uses synthetic nucleic acids to target and shut down specific, harmful genes and prevent viruses from spreading is gaining steam.

18 May 2021

Sperm deliver signals to female reproductive tissues to increase the chances of conception

Sperm are generally viewed as having just one action in reproduction - to fertilize the female's egg - but studies at the University of Adelaide are overturning that view.

18 May 2021

New atlas can help understand the relationship between healthy and breast cancer cells

Australian researchers have documented the diversity of cells in the human breast, explaining the relationship between healthy breast cells and breast cancer cells.

17 May 2021

Three-way strategy employed by SARS-CoV-2 during infection

The study, published in the journal Nature, reveals a multi-pronged strategy that the virus employs to ensure its quick and efficient replication while evading the immune system. The study elucidated how the virus can quickly, in a matter of hours, take over the cell's protein-making machinery and parallelly neutralize the cell's antiviral signaling, thus delaying and muddling the immune response.

13 May 2021

Certain immune cells unexpectedly change their behavior to cause psoriasis lesions

Millions of people suffer from psoriasis, a chronic, autoimmune disorder that causes scaly patches on the skin and often precedes psoriatic arthritis. While no cure exists, treatments range from topical creams to injected medications that block inflammation.

13 May 2021

SARS-CoV-2 virus uses a multipronged strategy to avoid detection by the immune system

Severe symptoms of COVID-19, leading often to death, are thought to result from the patient's own acute immune response rather than from damage inflicted directly by the virus.

13 May 2021

Study examines a pathway responsible for the formation of tau tangles in the brain

Since the discovery of Alzheimer's disease over a century ago, two hallmarks of the devastating illness have taken center stage.

12 May 2021

Scientists identify molecular mechanism behind weight gain in patients taking antipsychotics

Scientists with UT Southwestern's Peter O'Donnell Jr. Brain Institute have identified the molecular mechanism that can cause weight gain for those using a common antipsychotic medication.

12 May 2021

Low dose of a four-drug combination helps prevent cancer metastasis in mice

Low doses of a four-drug combination helps prevent the spread of cancer in mice without triggering drug resistance or recurrence, shows a study published today in eLife.

11 May 2021

Severe COVID-19 linked to genetic clotting predisposition

Thus, the need to stratify the risk of severe or critical disease in patients presenting with SARS-CoV-2 infection remains a crying necessity. A new preprint research paper posted to the medRxiv server discusses the relationship between severe disease and pre-existing susceptibility to clots and other diseases of the cardiovascular system.

11 May 2021

New approach combines molecular and medical imaging data to diagnose cancer type

Despite our remarkable advances in medicine and healthcare, the cure to cancer continues to elude us. On the bright side, we have made considerable progress in detecting several cancers in earlier stages, allowing doctors to provide treatments that increase long-term survival.

11 May 2021

Researchers explore effects of reduced gravity on mouse skeletal muscles

Most of us have imagined how free it would feel to float around, like an astronaut, in conditions of reduced gravity. But have you ever considered what the effects of reduced gravity might have on muscles?

11 May 2021

Rice University neurobiologist wins NIH grant to study enteric nervous system development

Rice University neurobiologist Rosa Uribe will be hitting the books for her latest study of the digestive system, but some of the pages in her books are a billion years old.

10 May 2021

Normalizing cholesterol metabolism in microglia alleviates chronic neuropathic pain

Chemotherapy can induce a painful peripheral neuropathy (CIPN), a chronic condition and common adverse effect for cancer patients undergoing treatment.

10 May 2021

Inflammasomes could play an important role in the development of obesity-related colon cancer

New research presented at this year's European Congress on Obesity (held online, 10-13 May) finds evidence that structures called inflammasomes (a part of the innate immune system that helps to regulate inflammation) could play an important role in the development of obesity-associated colon cancer.

10 May 2021

High-throughput system can regulate gene expression for treating sickle cell disease, beta thalassemia

St. Jude Children's Research Hospital scientists have developed an integrated, high-throughput system to better understand and possibly manipulate gene expression for treatment of disorders such as sickle cell disease and beta thalassemia. The research appears today in the journal Nature Genetics.

7 May 2021

Researchers describe the key facet of sexual determination in mammalian models

Early in human development, during the first trimester of gestation, a fetus may have XX or XY chromosomes that indicate its sex. Yet at this stage a mass of cells known as the bipotential gonad that ultimately develops into either ovaries or testes has yet to commit to its final destiny.

7 May 2021

Study provides a better understanding of the complex interplay of ncRNAs with gene regulation

Researchers at the University of Eastern Finland have discovered previously unknown non-coding RNAs (ncRNAs) involved in regulating the gene expression of vascular endothelial growth factors (VEGF), the master regulators of angiogenesis.

6 May 2021

Study reveals a new form of muscular dystrophy associated with pathogenic changes in JAG2 gene

In about a quarter of patients with hereditary diseases, the cause of the disease remains unclear even after extensive genetic testing. One reason is that we still do not know enough about the function of many genes. Of the 30,000 known genes, just a little more than 4,000 have been found to be associated with hereditary diseases.

6 May 2021

Gene Expression News and Research

Further Reading

New study will help investigate innate immune responses to viral infections

A promising drug delivery system for therapeutics that shut down harmful genes

Sperm deliver signals to female reproductive tissues to increase the chances of conception

New atlas can help understand the relationship between healthy and breast cancer cells

Three-way strategy employed by SARS-CoV-2 during infection

Certain immune cells unexpectedly change their behavior to cause psoriasis lesions

SARS-CoV-2 virus uses a multipronged strategy to avoid detection by the immune system

Study examines a pathway responsible for the formation of tau tangles in the brain

Scientists identify molecular mechanism behind weight gain in patients taking antipsychotics

Low dose of a four-drug combination helps prevent cancer metastasis in mice

Severe COVID-19 linked to genetic clotting predisposition

New approach combines molecular and medical imaging data to diagnose cancer type

Researchers explore effects of reduced gravity on mouse skeletal muscles

Rice University neurobiologist wins NIH grant to study enteric nervous system development

Normalizing cholesterol metabolism in microglia alleviates chronic neuropathic pain

Inflammasomes could play an important role in the development of obesity-related colon cancer

High-throughput system can regulate gene expression for treating sickle cell disease, beta thalassemia

Researchers describe the key facet of sexual determination in mammalian models

Study provides a better understanding of the complex interplay of ncRNAs with gene regulation

Study reveals a new form of muscular dystrophy associated with pathogenic changes in JAG2 gene

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