Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Researchers engineer enucleated cells to deliver therapeutics precisely to diseased tissues

Researchers at University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health report successfully removing the nucleus out of a type of ubiquitous cell, known as enucleation, then using the genetically engineered cell as a unique cargo-carrier to deliver therapeutics precisely to diseased tissues.

17 Jan 2022

Study shows AI systems can accurately identify and grade prostate cancer

Researchers at Karolinska Institutet in Sweden have together with international collaborators completed a comprehensive international validation of artificial intelligence (AI) for diagnosing and grading prostate cancer.

13 Jan 2022

What patients can learn with confidence from one negative rapid test (hint: very little)

Julie Ann Justo, an infectious disease clinical pharmacist for a South Carolina hospital system, hoped Christmas week would finally be the time her family could safely gather for a reunion.

13 Jan 2022

Ultra-rapid genome sequencing technology can detect rare genetic diseases in eight hours

A new ultra-rapid genome sequencing approach developed by Stanford Medicine scientists and their collaborators was used to diagnose rare genetic diseases in an average of eight hours - a feat that's nearly unheard of in standard clinical care.

13 Jan 2022

Metabolic vulnerabilities in malignant cells may lead to new breast cancer therapies

Metabolic differences could explain why some metastatic breast cancer cells rapidly generate tumors after migrating from primary tumors to the brain, while others linger for months or years before forming these secondary tumors, UT Southwestern scientists report in a new study.

12 Jan 2022

Discovery of new protein could lead to effective treatments for developmental, neurological disorders

Understanding how the brain develops is crucial to formulating treatments and management protocols for a variety of developmental disorders, as well as degenerative neurological diseases. Right from the embryonic stage, brain development is facilitated by the differentiation of neurons (brain cells).

12 Jan 2022

Phase 1 clinical trial shows the safety, feasibility of CAR-M cell therapy for solid tumors

Preliminary findings from Penn Medicine in an ongoing first-in-human clinical trial examining the safety, tolerability and feasibility of chimeric antigen receptor macrophage (CAR-M) has helped to establish the viability of this innovative immunotherapy, which advances the trailblazing scientific discovery of CAR T cell therapy- also pioneered at Penn- for solid cancer tumors and offers a promising new strategy in the fight against cancer.

11 Jan 2022

Novel mechanism linking intercellular adhesion molecule with genetic skin diseases discovered

Northwestern Medicine investigators have discovered a novel mechanism linking an intercellular adhesion molecule with genetic inflammatory skin diseases, according to findings published in the Journal of Clinical Investigation.

11 Jan 2022

Developing a 'fingerprint' test that could diagnose Alzheimer’s early

In this interview, we spoke to Dr. Cynthia McMurray about her latest research into Alzheimer's disease.

11 Jan 2022

COVID-19 symptoms found to vary in different immune contexts

In a new study, researchers studied the kinetics of host response to SARS-CoV-2 infection in a Syrian hamster model, tracking disease pathology, viral loads, antibody responses, and inflammatory cytokine production in multiple organs.

11 Jan 2022

New neural circuits regulating spatial learning, memory in the brain's hippocampal formation discovered

A research team led by University of California, Irvine has discovered new neural circuits that regulate spatial learning and memory in the brain's hippocampal formation.

10 Jan 2022

Research may lead to new treatment options for Crohn's disease patients

Results of a new study by researchers at Case Western Reserve University represent a step toward improving our understanding of Crohn's disease and the factors that cause its intestinal inflammation.

10 Jan 2022

Lab engineered human A549 lung cell model conducive for investigating SARS-CoV-2 antivirals

Researchers developed a human A549 lung epithelial cell-based model to probe SARS-CoV-2 replication.

9 Jan 2022

Slight pH adjustment may turn a metabolic inhibiting drug into promising COVID-19 treatment

Mechanical engineering and materials science professor David Needham has shown that a slight increase in solution pH might be all it takes to turn a metabolic inhibiting drug, traditionally used to treat gut parasites, into a promising prophylactic/preventative nasal spray and early treatment throat spray for COVID-19.

7 Jan 2022

Physical activity may help boost synaptic functioning in older adults

When elderly people stay active, their brains have more of a class of proteins that enhances the connections between neurons to maintain healthy cognition, a UC San Francisco study has found.

7 Jan 2022

Study provides deeper insights into familial Alzheimer's disease pathogenesis

Alzheimer's disease (AD) is a progressive neurological disease that causes impairments in memory and cognition. AD is believed to result from the deposition of protein "plaques" consisting of amyloid beta (Aβ) proteins sequentially generated via the enzyme γ-secretase.

7 Jan 2022

Grouping tumors by 'immune archetypes' points the way to personalized immunotherapies

The UCSF researchers, led by first co-authors Alexis Combes, PhD, and Bushra Samad, MS, and senior author, Max Krummel, PhD, obtained tumor specimens from 78 UCSF clinicians, and surveyed 364 tumors biopsies from patients and categorized them into groups based on their immune microenvironment.

7 Jan 2022

SARS-CoV-2 Omicron less pathogenic in hamsters

A new research paper posted as a preprint to the bioRxiv* server attempts to throw some light on this question by studying viral pathogenicity in golden hamsters, a valuable model for severe COVID-19 due to the development of reproducible weight loss and pneumonia after infection with the virus.

6 Jan 2022

CDC raises awareness of the risks of rabies from bats in the U.S.

The Centers for Disease Control and Prevention (CDC) is raising awareness of the risks of rabies from bats in the U.S. after three people, including one child, died from rabies between late September and early November 2021.

6 Jan 2022

Scientists find that having one kind of autoimmune disease can lead to another

Researchers at the University of Colorado Anschutz Medical Campus have discovered that having one kind of autoimmune disease can lead to another.

4 Jan 2022

Pathology News and Research

Further Reading

Researchers engineer enucleated cells to deliver therapeutics precisely to diseased tissues

Study shows AI systems can accurately identify and grade prostate cancer

What patients can learn with confidence from one negative rapid test (hint: very little)

Ultra-rapid genome sequencing technology can detect rare genetic diseases in eight hours

Metabolic vulnerabilities in malignant cells may lead to new breast cancer therapies

Discovery of new protein could lead to effective treatments for developmental, neurological disorders

Phase 1 clinical trial shows the safety, feasibility of CAR-M cell therapy for solid tumors

Novel mechanism linking intercellular adhesion molecule with genetic skin diseases discovered

Developing a 'fingerprint' test that could diagnose Alzheimer’s early

COVID-19 symptoms found to vary in different immune contexts

New neural circuits regulating spatial learning, memory in the brain's hippocampal formation discovered

Research may lead to new treatment options for Crohn's disease patients

Lab engineered human A549 lung cell model conducive for investigating SARS-CoV-2 antivirals

Slight pH adjustment may turn a metabolic inhibiting drug into promising COVID-19 treatment

Physical activity may help boost synaptic functioning in older adults

Study provides deeper insights into familial Alzheimer's disease pathogenesis

Grouping tumors by 'immune archetypes' points the way to personalized immunotherapies

SARS-CoV-2 Omicron less pathogenic in hamsters

CDC raises awareness of the risks of rabies from bats in the U.S.

Scientists find that having one kind of autoimmune disease can lead to another

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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