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Scientists identify molecules in mucus that can block cholera infection

MIT researchers have identified molecules found in mucus that can block cholera infection by interfering with the genes that cause the microbe to switch into a harmful state.

13 Dec 2022

Nanomaterial can indirectly affect the immune system via the gut microbiome, study shows

The nanomaterial graphene oxide - which is used in everything from electronics to sensors for biomolecules - can indirectly affect the immune system via the gut microbiome, as shown in a new study on zebrafish by researchers at Karolinska Institutet in Sweden.

12 Dec 2022

Study provides new insights for the future development of oral insulin pill

WEHI researchers in Melbourne have answered a 100-year-old question in diabetes research: can a molecule different to insulin have the same effect? The findings provide important insights for the future development of an oral insulin pill.

12 Dec 2022

Novel monoclonal antibody therapy shows promising results in patients with moderate to severe atopic dermatitis

Patients with moderate to severe atopic dermatitis who participated in a clinical trial of rocatinlimab - a novel, patient-tailored monoclonal antibody therapy - showed promising results both while taking the drug and up to 20 weeks after the therapy was stopped, Mount Sinai researchers reported in The Lancet.

12 Dec 2022

Researchers seek to reduce Chikungunya virus-caused joint pain with new drug

Oregon Health & Science University researchers and partners are developing what could become the first-ever treatment against the debilitating joint pain that can last months or years after becoming infected with the emerging Chikungunya virus.

9 Dec 2022

Study shows how an inflammatory molecule causes life-threatening airway damage in asthma patients

An inflammatory molecule called LIGHT, appears to be the cause of life-threatening airway damage in patients with severe asthma.

9 Dec 2022

Researchers design novel compounds with potential as drug treatments for COVID-19

The ongoing COVID-19 pandemic, caused by the SARS-CoV-2 virus, has been devastating the entire world. While the vaccination program is advancing, drug treatments for COVID-19 are still highly important for those who become infected.

9 Dec 2022

Landmark study challenges a 70-year-old theory of protein folding

A landmark study by researchers at the Department of Energy’s SLAC National Accelerator Laboratory and Stanford University reveals how a tiny cellular machine called TRiC directs the folding of tubulin, a human protein that is the building block of microtubules that serve as the cell’s scaffolding and transport system.

9 Dec 2022

Better understanding of DNA repair mechanism may pave the way for effective cancer treatments

Better understanding of the mechanisms involved in DNA repair may pave the way for developing inhibitors to improve the effectiveness of radiation therapy.

9 Dec 2022

Discovery of cellular uptake pathway for larger molecules can be harnessed to create new drugs

A fundamental challenge in drug development is the balance between optimizing a drug's lock-and-key fit with its target and the drug's ability to make its way across the cellular membrane and access that target.

8 Dec 2022

Therapeutic activation of p53 could offer new treatment option for salivary gland cancer

Researchers at the University of Michigan Rogel Cancer Center and School of Dentistry found that certain drugs can change the fundamental makeup of cancer stem cells in mouse models of mucoepidermoid carcinoma – a lethal form of salivary gland cancer that currently has no treatment options.

8 Dec 2022

Multi-stage HIV vaccine regimen shows promising results in Phase 1 clinical trial

The George Washington University Vaccine Research Unit in partnership with Scripps Research, IAVI, Fred Hutchinson Cancer Center (FHCC) and the National Institutes of Health, National Institute of Allergy and Infectious Diseases Vaccine Research Center published the results of their Phase 1 Clinical Trial in Science.

8 Dec 2022

Scientists develop new receptor “decoy” drug that potently neutralizes SARS-CoV-2 variants

Scientists at Dana-Farber Cancer Institute have developed a drug that potently neutralizes SARS-CoV-2, the COVID-19 coronavirus, and is equally effective against the Omicron variant and every other tested variant.

7 Dec 2022

Wearable technology could improve doctors' ability to administer precise medication doses

For some of the powerful drugs used to fight infection and cancer, there's only a small difference between a healing dose and a dose that's large enough to cause dangerous side effects.

7 Dec 2022

Owlstone Medical Presents Breath Biopsy® VOC Atlas

Owlstone Medical has embarked on an exciting project to better understand the diversity of molecules in a given breath sample

From Owlstone Medical Ltd 7 Dec 2022

Metrion Biosciences and The KCNC1 Foundation Collaborate on New Ion Channel Modulators

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From Metrion Biosciences Limited 7 Dec 2022

Pre-existing SARS-CoV-2 antibodies may increase the breadth of mRNA vaccines, study suggests

Nearly three years into the pandemic, many of us now carry antibodies against the virus - due to an infection or two, a few doses of mRNA vaccine, or a round of monoclonal-antibody treatment.

6 Dec 2022

Research extends the powerful tool of immunotherapy to autoimmune diseases

The cancer therapy known as CAR-T has revolutionized treatment of some blood cancers since it was introduced in 2017. The therapy uses genetically altered immune cells to home in on cancer cells and destroy them.

6 Dec 2022

Study suggests new anti-KRAS drug as a strong candidate for pancreatic cancer clinical trials

A small molecule inhibitor that attacks the difficult to target, cancer-causing gene mutation KRAS, found in nearly 30 percent of all human tumors, successfully shrunk tumors or stopped cancer growth in preclinical models of pancreatic cancer, researchers from Penn Medicine's Abramson Cancer Center showed, suggesting the drug is a strong candidate for clinical trials.

6 Dec 2022

Researchers uncover the host protease CAPN2 as a novel host factor that aids the infection of SARS-CoV-2

Researchers investigated the potential of the CAPN2 molecule as a therapeutic target against SARS-CoV-2.

5 Dec 2022

Molecule News and Research

Scientists identify molecules in mucus that can block cholera infection

Nanomaterial can indirectly affect the immune system via the gut microbiome, study shows

Study provides new insights for the future development of oral insulin pill

Novel monoclonal antibody therapy shows promising results in patients with moderate to severe atopic dermatitis

Researchers seek to reduce Chikungunya virus-caused joint pain with new drug

Study shows how an inflammatory molecule causes life-threatening airway damage in asthma patients

Researchers design novel compounds with potential as drug treatments for COVID-19

Landmark study challenges a 70-year-old theory of protein folding

Better understanding of DNA repair mechanism may pave the way for effective cancer treatments

Discovery of cellular uptake pathway for larger molecules can be harnessed to create new drugs

Therapeutic activation of p53 could offer new treatment option for salivary gland cancer

Multi-stage HIV vaccine regimen shows promising results in Phase 1 clinical trial

Scientists develop new receptor “decoy” drug that potently neutralizes SARS-CoV-2 variants

Wearable technology could improve doctors' ability to administer precise medication doses

Owlstone Medical Presents Breath Biopsy® VOC Atlas

Metrion Biosciences and The KCNC1 Foundation Collaborate on New Ion Channel Modulators

Pre-existing SARS-CoV-2 antibodies may increase the breadth of mRNA vaccines, study suggests

Research extends the powerful tool of immunotherapy to autoimmune diseases

Study suggests new anti-KRAS drug as a strong candidate for pancreatic cancer clinical trials

Researchers uncover the host protease CAPN2 as a novel host factor that aids the infection of SARS-CoV-2

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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