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Certain oral pathogens are more prevalent in esophageal cancer patients

Researchers led by Tokyo Medical and Dental University (TMDU) find that certain oral pathogens are more prevalent in esophageal cancer patients, and could be used as a novel diagnostic tool.

14 Jan 2021

New tests may help reveal the transcriptome of SARS-CoV-2 and predict disease course

As the COVID-19 pandemic continues to infect people in their hundreds of thousands around the world, a new study describes a panel of novel tests for genomic (g) and subgenomic (sg) mRNAs generated by SARS-CoV-2. Most assays in use at present are either qualitative or semi-quantitative, and cannot evaluate the transcription molecules in detail.

14 Jan 2021

No inflammation of cerebrospinal fluid in COVID-19 patients with neurological features, study finds

Many patients with COVID-19 have shown neurological complications, leading to scientific interest in the role played by its causative pathogen, SARS-CoV-2, in brain inflammation. A new study has described the absence of neuroinflammation in cerebrospinal fluid (CSF).

14 Jan 2021

Influenza drug enisamium a potential COVID-19 treatment

Researchers in Europe and the United States have demonstrated the potential of the influenza drug enisamium as a treatment for infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

13 Jan 2021

Hypoxia signaling pathway could lead to COVID-19 treatments

Researchers in Spain have demonstrated that studying the hypoxia signaling pathway could provide opportunities for treating coronavirus disease 2019 (COVID-19).

12 Jan 2021

The mystery of Giglio island’s resistance to COVID-19

An intriguing new study explores the mechanisms by which an Italian island called Giglio remained resistant to coronavirus disease 2019 (COVID-19) even after much exposure.

11 Jan 2021

Could Ivermectin be an effective antiviral against SARS-CoV-2?

A double-blind, randomized, placebo-controlled clinical trial has recently demonstrated that Ivermectin, an anti-parasitic drug, can reduce in-hospital mortality rate of COVID-19 patients.

11 Jan 2021

Study shows P681H mutation is becoming globally prevalent among SARS-CoV-2 sequences

In a recent bioRxiv preprint study, researchers from the University of Hawaii showed that the S gene of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is continuously mutating according to the sequence and phylogenetic analysis.

10 Jan 2021

New test detects SARS-CoV-2 in less than 5 mins

A fast and accurate virus detection strategy is very crucial to reduce the rate of transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the pathogen responsible for COVID-19. The global scientific research community responded to this unprecedented demand in diagnostic testing by developing several detection platforms, the most sensitive of which detect the viral RNA.

10 Jan 2021

Researchers develop a low-cost, saliva-optimized RT-LAMP assay for faster detection of SARS-CoV-2

SARS-CoV-2 pandemic has highlighted the shortcomings in emergency response globally and has driven a massive demand for in vitro diagnostic testing technologies. In order to address these issues, researchers from the US recently used the new pH dye LAMPShade Violet (LSV) in RT-LAMP. LSV has better visual contrast between high and low pH and a stronger inflection point, both of which enable easy interpretation of results and reduces ambiguity.

8 Jan 2021

A paper-based sensor for detecting COVID-19

News-Medical talks to Dipanjan Pan about the development of a paper-based electrochemical sensor that can detect COVID-19 in less than five minutes.

5 Jan 2021

Middle-aged adults with comorbidities high-risk category for COVID-19-related mortality in Mexican study

Researchers from Mexico demonstrate how they calculated age-stratified COVID-19 case fatality rates, years of life lost (YLL), and relative risk for 9 comorbidities and 23 comorbidity combinations in a retrospective study.

5 Jan 2021

Anti-SARS-CoV-2 NTD-directed antibodies are protective against lethal infection

As the world struggles to contain the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for over 1.6 million deaths and 76 million infections globally, researchers are trying to pin down the determinants of lethality, of infectivity and of protection. Such data would help contain its spread and develop preventive and therapeutic antivirals and vaccines. A new preprint that appeared recently on the bioRxiv* server describes the high degree of protection afforded by antibodies that target the N-terminal domain (NTD) of the virus.

24 Dec 2020

Frequent and rapid testing may reduce SARS-CoV-2 transmission in carehomes

A team of scientists from the Centers for Disease Control and Prevention, United States, recently conducted a study to evaluate the effectiveness of serial testing and isolation of healthcare personnel in nursing homes in preventing the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of coronavirus disease 2019 (COVID-19).

23 Dec 2020

New drug starves cancer cells by attacking mitochondria

A newly developed compound starves cancer cells by attacking their "power plants" - the so-called mitochondria.

22 Dec 2020

Study highlights the far-reaching effects of mutagenic compounds on human health

In order to survive, flourish and successfully reproduce, organisms rely on a high degree of genetic stability. Mutagenic agents, which can threaten the integrity of the genetic code by causing mutations in DNA, pose a serious risk to human health.

21 Dec 2020

COVID-19 contact tracing ineffective without timely testing and isolation, study says

A new study by Canada-based researchers has showed that contact tracing is not effective if testing and isolation are delayed.

21 Dec 2020

Study confirms the feasibility of RT-qPCR on extraction-free inactivated SARS-CoV-2 samples

A new paper reports superior results using an alternative test protocol for RT-qPCR testing for the SARS-CoV-2 virus.

21 Dec 2020

Pooled COVID-19 testing methods could detect outbreaks in schools, says study

A team of researchers at Tufts University, USA, has found that pool testing in schools and universities can identify COVID-19 patients. This way, schools can immediately report the case, refer the staff to health departments, and conduct contact tracing.

21 Dec 2020

COVID-19 spread in cities driven by socioeconomically weaker groups, study finds

Researchers in Sweden have conducted a study showing that the transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within cities is driven by socioeconomically weaker and high-mobility groups. They used Basel, Switzerland as their case study.

21 Dec 2020

Polymerase News and Research

Certain oral pathogens are more prevalent in esophageal cancer patients

New tests may help reveal the transcriptome of SARS-CoV-2 and predict disease course

No inflammation of cerebrospinal fluid in COVID-19 patients with neurological features, study finds

Influenza drug enisamium a potential COVID-19 treatment

Hypoxia signaling pathway could lead to COVID-19 treatments

The mystery of Giglio island’s resistance to COVID-19

Could Ivermectin be an effective antiviral against SARS-CoV-2?

Study shows P681H mutation is becoming globally prevalent among SARS-CoV-2 sequences

New test detects SARS-CoV-2 in less than 5 mins

Researchers develop a low-cost, saliva-optimized RT-LAMP assay for faster detection of SARS-CoV-2

A paper-based sensor for detecting COVID-19

Middle-aged adults with comorbidities high-risk category for COVID-19-related mortality in Mexican study

Anti-SARS-CoV-2 NTD-directed antibodies are protective against lethal infection

Frequent and rapid testing may reduce SARS-CoV-2 transmission in carehomes

New drug starves cancer cells by attacking mitochondria

Study highlights the far-reaching effects of mutagenic compounds on human health

COVID-19 contact tracing ineffective without timely testing and isolation, study says

Study confirms the feasibility of RT-qPCR on extraction-free inactivated SARS-CoV-2 samples

Pooled COVID-19 testing methods could detect outbreaks in schools, says study

COVID-19 spread in cities driven by socioeconomically weaker groups, study finds

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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