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How two structurally different lemon pectins modulate the gut microbiota

A diet containing fruits and vegetables contains pectins (plant polysaccharides). Pectin cannot be metabolized by mammalian cells in the gastrointestinal tract but is fermented by the gut microbiota in the colon, where short-chain fatty acids (SCFAs) are released. Previous studies have examined pectin's prebiotic properties.

4 Dec 2022

Exploring the effects of dietary fiber on gut microbiome and inflammatory diseases

Researchers reviewed how dietary fibers modulate the composition and function of gut microbiota.

2 Dec 2022

Integrated approach addresses some of the biggest challenges in natural products drug discovery

Many successful drugs have their origins in natural sources such as plants, fungi, and bacteria, but screening natural products to identify potential drugs remains a difficult undertaking.

1 Dec 2022

New, nanotech-based strategy could enable safe, long-term treatment for autoimmune diseases

Scientists at Scripps Research have reported success in initial tests of a new, nanotech-based strategy against autoimmune diseases.

1 Dec 2022

Phase 2 clinical trial of DS-1211 begins for individuals with Pseudoxanthoma Elasticum

A Phase 2 clinical trial has started of DS-1211 in individuals with Pseudoxanthoma Elasticum (PXE), a rare multisystem genetic disease that causes calcium deposits in soft tissue resulting in considerable morbidity.

1 Dec 2022

Detection of filoviruses by the innate immune system

In a new study, researchers examined how the innate immune system detects filoviruses.

1 Dec 2022

Study suggests new strategies for making cartilage cells

As any weekend warrior understands, cartilage injuries to joints such as knees, shoulders, and hips can prove extremely painful and debilitating. In addition, conditions that cause cartilage degeneration, like arthritis and temporomandibular joint disorder (TMJ), affect 350 million people in the world and cost the US public health system more than $303 billion every year.

30 Nov 2022

Human fetal cerebellar cell atlas reveals the origin of aggressive medulloblastomas

Studying mice has filled encyclopedias with breakthrough medical discoveries. But when it comes to brain cancers, the little rodents have long exhibited fundamental limitations.

30 Nov 2022

New guidelines for designing synthetic molecules that block interaction between two proteins

Inside cells, proteins constantly interact with each other to carry out different functions. For some diseases in which these functions are altered, blocking the binding between two or more proteins emerges as a possible therapeutic approach.

30 Nov 2022

Broadly cross-reactive antibodies that protect from SARS-CoV-2 variants are revealed by virus coldspot-driven discovery

A recent study identified neutralizing antibodies against conserved SARS-CoV-2 epitopes.

30 Nov 2022

Bioorthogonal system for targeted release of nitrite ions into cancer cells

A team of researchers writing in the journal Angewandte Chemie has developed a bioorthogonal molecular system for the targeted introduction of nitrite ions into cells.

30 Nov 2022

UAB and Menkes International Association sign a donation agreement to boost research in Menkes disease

These funds, coming from the Menkes International Association, will allow a research project to search for new biomarkers to establish administration and monitoring protocols for a new drug that could improve the lives of children suffering from this rare disease.

29 Nov 2022

Molecule News and Research

How two structurally different lemon pectins modulate the gut microbiota

Exploring the effects of dietary fiber on gut microbiome and inflammatory diseases

Integrated approach addresses some of the biggest challenges in natural products drug discovery

New, nanotech-based strategy could enable safe, long-term treatment for autoimmune diseases

Phase 2 clinical trial of DS-1211 begins for individuals with Pseudoxanthoma Elasticum

Detection of filoviruses by the innate immune system

Study suggests new strategies for making cartilage cells

Human fetal cerebellar cell atlas reveals the origin of aggressive medulloblastomas

New guidelines for designing synthetic molecules that block interaction between two proteins

Broadly cross-reactive antibodies that protect from SARS-CoV-2 variants are revealed by virus coldspot-driven discovery

Bioorthogonal system for targeted release of nitrite ions into cancer cells

UAB and Menkes International Association sign a donation agreement to boost research in Menkes disease

New computer-based platform could make drug discovery process more efficient and less expensive

New chemical probe can selectively inhibit human COQ8A protein in cells

Researchers discover a new function of CRISPR/Cas9 gene scissors

AI helps design synthetic DNA that controls cells' protein production

Pocket feature in SARS-CoV-2 spike protein is present in all deadly coronaviruses, study reveals

Study reveals structural insights into the elusive tankyrase protein that fuels bowel cancer

Researchers make an incredible discovery about mammalian brains

Single drug compound may offer a promising new strategy for treating prostate cancer patients

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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