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Study demonstrates new method to synthesize gold nanoparticles in cancer cells

Dipanjan Pan, professor of chemical, biochemical, and environmental engineering at UMBC, and collaborators published a seminal study in Nature Communications that demonstrates for the first time a method of biosynthesizing plasmonic gold nanoparticles within cancer cells, without the need for conventional bench-top lab methods.

12 Sep 2020

New antitumor vaccines control melanoma growth in preclinical models

Combining their expertise in protein engineering and synthetic DNA technology, scientists at The Wistar Institute successfully delivered nanoparticle antitumor vaccines that stimulated robust CD8 T cell immunity and controlled melanoma growth in preclinical models.

11 Sep 2020

Effective, simple, safe self-amplifying RNA vaccines

A recent review paper in the journal Current Opinion in Virology in September 2020 shows how a new generation of RNA vaccines called self-amplifying RNA vaccines are more potent than conventional mRNA vaccines and could hold the key to the global production of cost-effective potent COVID-19 vaccines.

11 Sep 2020

DLnano-vaccines may be a promising strategy for cancer immunotherapy

Researchers designed DLnano-vaccines displaying 60 copies of protein parts derived from the melanoma-specific antigens Trp2 and Gp100 and tested these in mouse models of melanoma, observing prolonged survival that depended on CD8 T cell activation both in therapeutic and prophylactic settings.

10 Sep 2020

Scientists explain how SARS-CoV-2 attacks the brain

Now, a team of scientists at Yale University revealed the changes that happen in the brain caused by SARS-CoV-2, the virus that has caused over 27.86 million people and claimed over 903,000 lives.

10 Sep 2020

Pfizer, BioNTech COVID-19 vaccine candidate shows promise in preclinical study

Researchers in the United States and Germany have conducted a study demonstrating the preclinical efficacy of a new candidate vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent that causes coronavirus disease 2019 (COVID-19).

9 Sep 2020

Study sheds new light on function and regulation of APOBEC3B in adrenocortical carcinoma

The cover for issue 36 of Oncotarget features, "Knockdown of APOBEC3B is associated with a lower tumor growth in an adrenocortical carcinoma xenograft mouse model," by Gara, et al. which reported that the role of APOBEC3B in adrenocortical carcinoma and the mechanisms through which its expression is regulated in cancer are not fully understood.

9 Sep 2020

Scientists explain why men are at higher risk from COVID-19

Published in the journal PLOS Biology, the study aimed to provide a better understanding of the mechanisms that drive the varying responses of the infected individuals among different patient demographics, including sex and age.

9 Sep 2020

New medical instruments with smart sensors can improve surgery, therapy for cardiac diseases

Researchers developed a new class of medical instruments equipped with an advanced soft electronics system that could dramatically improve the diagnoses and treatments of a number of cardiac diseases and conditions.

7 Sep 2020

Novel RNA vaccine from Arcturus Therapeutics protects mice against SARS-CoV-2

A new study published on the preprint server bioRxiv in September 2020 reports a novel RNA vaccine platform that shows robust protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in mice and performs much better than a conventional mRNA vaccine. This could allow single-dose immunization, allowing progress towards global vaccination.

6 Sep 2020

Seasonal influenza and COVID-19 risk

In a new study published on the preprint server medRxiv, researchers from Laval University and McGill University in Canada reviewed evidence from 18 relevant studies on a possible interaction between influenza vaccines on non-influenza respiratory disease (NIRD).

6 Sep 2020

Study: Small neutralizing antibody can block SARS-CoV-2 from entering human cells

Researchers at Karolinska Institutet in Sweden have identified a small neutralizing antibody, a so-called nanobody, that has the capacity to block SARS-CoV-2 from entering human cells.

4 Sep 2020

Scientists find promising drug candidates for treatment of motor neurone disease

Scientists have taken a significant step forward in the search to find effective new drug candidates for the treatment of motor neurone disease.

1 Sep 2020

Spike ferritin nanoparticles show potential as SARS-CoV-2 vaccine

Now, a new study published on the preprint server bioRxiv* in August 2020 reports the induction of neutralizing antibodies in mice by a single dose of a ferritin nanoparticle-based vaccine containing the spike protein.

1 Sep 2020

Researchers identify roles of matrix stiffness and mechanotransduction in cardiac reprogramming

Cardiovascular disease is the leading cause of death in humans. Worldwide, as the population ages, the burden of treating heart failure is increasing; opportunities for heart transplantation cannot keep pace.

31 Aug 2020

Virginia Tech researcher wins NIH award to study possible treatments for metastatic breast cancer

Eli Vlaisavljevich, an assistant professor of biomedical engineering and mechanics at Virginia Tech, received a Trailblazer Award from the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health to research possible treatments for metastatic breast cancer.

28 Aug 2020

Manipulating 3D Printed Organoid Microenvironments

Organoids are 3-dimensional (3D) clusters of stem cells that come together and emulate the microenvironment within individual organs, whether that be liver, kidney, heart, gut or other specific organs.

From Manchester BIOGEL 28 Aug 2020

Researchers develop advanced imaging technique to visualize effects of valencies on B cell responses

Designing a vaccine starts with finding the right ingredients. Every infectious agent has molecules, called antigens, that the immune system could potentially recognize and attack. So scientists must carefully consider which antigens should go into a vaccine.

28 Aug 2020

Study shows furin cleavage site is crucial for SARS-CoV-2 replication

In a recent bioRxiv* preprint paper, researchers from the United States demonstrate the pivotal role the furin cleavage site insertion in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein plays in viral replication and pathogenesis – highlighting, in turn, the need for mutation monitoring when developing therapeutics and vaccines.

27 Aug 2020

Heat Biologics SARS-CoV-2 vaccine generates potent T cell response in pre-clinical trial

The COVID-19 pandemic is still creating economic and health-related impact over the world. A new study published on the preprint server bioRxiv in August 2020 shows that a gp96-Ig-secreting vaccine candidate based on the expression of full-length spike protein generates a potent T cell response.

26 Aug 2020

in vivo News and Research

Study demonstrates new method to synthesize gold nanoparticles in cancer cells

New antitumor vaccines control melanoma growth in preclinical models

Effective, simple, safe self-amplifying RNA vaccines

DLnano-vaccines may be a promising strategy for cancer immunotherapy

Scientists explain how SARS-CoV-2 attacks the brain

Pfizer, BioNTech COVID-19 vaccine candidate shows promise in preclinical study

Study sheds new light on function and regulation of APOBEC3B in adrenocortical carcinoma

Scientists explain why men are at higher risk from COVID-19

New medical instruments with smart sensors can improve surgery, therapy for cardiac diseases

Novel RNA vaccine from Arcturus Therapeutics protects mice against SARS-CoV-2

Seasonal influenza and COVID-19 risk

Study: Small neutralizing antibody can block SARS-CoV-2 from entering human cells

Scientists find promising drug candidates for treatment of motor neurone disease

Spike ferritin nanoparticles show potential as SARS-CoV-2 vaccine

Researchers identify roles of matrix stiffness and mechanotransduction in cardiac reprogramming

Virginia Tech researcher wins NIH award to study possible treatments for metastatic breast cancer

Manipulating 3D Printed Organoid Microenvironments

Researchers develop advanced imaging technique to visualize effects of valencies on B cell responses

Study shows furin cleavage site is crucial for SARS-CoV-2 replication

Heat Biologics SARS-CoV-2 vaccine generates potent T cell response in pre-clinical trial

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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