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Cancer Research Horizons: The Innovation Engine of Cancer Research UK

Following ELRIG 2022, News-Medical speaks with Cancer Research Horizons, the innovation engine of Cancer Research UK about their efforts to advance the drug discovery sector.

From Cancer Research UK 14 Nov 2022

Researchers receive NIH grant to develop mRNA vaccines to deter cancer development

A multidisciplinary team of Weill Cornell Medicine researchers have received a five-year $5.7 million grant from the National Cancer Institute at the National Institutes of Health to fund a center aimed at developing messenger RNA (mRNA) vaccines to deter cancer development in at-risk groups.

11 Nov 2022

Study demonstrates immuno-based strategies to explore the treatment and prevention of COVID-19

Millions have died due to COVID-19 infection, and millions more continue experiencing the chronic condition, Long COVID, which makes discovering practical, accessible, and powerful SARS-CoV-2 preventatives and COVID-19 treatments essential.

11 Nov 2022

Researchers discover new antiviral compounds derived from two Korean native plants

Codonopsis lanceolata, more commonly referred to as "deodeok", is used as a medicinal herb in South Korea.

11 Nov 2022

Nanotechnology platform can make solid tumor cells more receptive to immunotherapy

A team of researchers at The University of Texas MD Anderson Cancer Center has developed a nanotechnology platform that can change the way the immune system sees solid tumor cells, making them more receptive to immunotherapy.

10 Nov 2022

TYK2 inhibitor identifies as a promising drug candidate for preventing type 1 diabetes

According to a study, type 1 diabetes could be prevented by inhibiting a gene associated with the onset of the disease.

10 Nov 2022

Biodegradable transport nanoparticle can make anti-inflammatory drug more effective and less toxic

A team from UNIGE and LMU developed a transport nanoparticle to make an anti-inflammatory drug much more effective and less toxic.

9 Nov 2022

Researchers find an innovative approach to improve waste clearance from the brain

Alzheimer's, Parkinson's and many other neurodegenerative diseases are marked by damaging clusters of proteins in the brain. Scientists have expended enormous effort searching for ways to treat such conditions by clearing these toxic clusters but have had limited success.

9 Nov 2022

Collaboration aims to develop new medicines for neurodegenerative diseases

The ALBORADA Drug Discovery Institute (ADDI) today (Tuesday 8 November) announced that it will collaborate with pharmaceutical company YD Global Life Science (YDGLS) to develop inhibitors of the unfolded protein response for the treatment of the diseases that cause dementia.

9 Nov 2022

Researchers use lasso-grafting for designing receptor agonists with enhanced pharmacokinetics

Cell growth and repair are stimulated by biomolecules known as cytokines and growth factors. Unfortunately, delivering adequate concentrations of these molecules to the brain for treating neurological conditions like Alzheimer's disease is challenging as they are either cleared out of the blood very quickly or do not penetrate neural tissue effectively.

8 Nov 2022

New urine tests for early diagnosis of chronic kidney disease

Early diagnosis of chronic kidney disease (CKD) is key to managing progression of the disease. A new technique analyzing urine extracellular vesicles (uEVs) - cell-derived nanoscale spherical structures involved in multiple biological functions - in urine samples identifies changes in the kidneys earlier than conventional methods and can also predict renal function decline.

8 Nov 2022

SARS-CoV-2 activates NLRP3 inflammasome

Researchers assessed the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the NLR family pyrin domain containing 3 (NLRP3) inflammasome activation.

7 Nov 2022

Heart attack patients without modifiable risk factors are common and fare better, study finds

A new study by researchers at Intermountain Healthcare in Salt Lake City finds that patients without standard modifiable heart risk factors who experience a heart attack are common and more likely to fare better than heart-attack patients with known risk factors, but researchers say it remains difficult to identify those at risk for an event before it happens.

6 Nov 2022

Scientists map neural pathways that lead to vomiting after eating contaminated food

A new study describes a system by which gut-brain pathways coordinate with brain circuits to initiate nausea and vomiting.

6 Nov 2022

Anti-herpes drug can fight against antibiotic-resistant bacterium

A UNIGE team reveals that a drug used against herpes can fight a bacterium that is resistant to most antibiotics by weakening its defense mechanisms.

4 Nov 2022

UQ spin-off company to develop precision painkillers for treating debilitating conditions

Precision painkillers that are more accurate and less harmful to the liver are set to be developed by a University of Queensland spin-off company - potentially changing the lives of millions of people.

3 Nov 2022

Researchers provide insights on how to overcome resistance in cancer therapy

The latest developmental drugs, particularly for the use in oncology, rely on the targeted degradation of harmful pathogenic proteins.

3 Nov 2022

New method to estimate the contribution of each amino acid residue

You can't expect a pharmaceutical scientist to switch labs to the facilities available in a television studio and expect the same research output. Enzymes behave exactly the same. But now, in a study recently published in ACS Synthetic Biology, researchers from Osaka University have imparted an analogous level of adaptability to enzymes, a goal that has remained elusive for over 30 years.

3 Nov 2022

Study provides new set of targets for drug therapies to combat chronic inflammatory diseases

Innate lymphoid cells are a recently discovered family of white blood cells that reside in the skin, gastrointestinal tract, airways and other barrier tissues of the body.

2 Nov 2022

Nebulized mRNA-encoded antibodies found to protect hamsters against COVID-19

New research describes a novel route of prevention, using messenger ribonucleic acid (mRNA) molecules that encode protective antibodies within the recipient.

2 Nov 2022

Molecule News and Research

Cancer Research Horizons: The Innovation Engine of Cancer Research UK

Researchers receive NIH grant to develop mRNA vaccines to deter cancer development

Study demonstrates immuno-based strategies to explore the treatment and prevention of COVID-19

Researchers discover new antiviral compounds derived from two Korean native plants

Nanotechnology platform can make solid tumor cells more receptive to immunotherapy

TYK2 inhibitor identifies as a promising drug candidate for preventing type 1 diabetes

Biodegradable transport nanoparticle can make anti-inflammatory drug more effective and less toxic

Researchers find an innovative approach to improve waste clearance from the brain

Collaboration aims to develop new medicines for neurodegenerative diseases

Researchers use lasso-grafting for designing receptor agonists with enhanced pharmacokinetics

New urine tests for early diagnosis of chronic kidney disease

SARS-CoV-2 activates NLRP3 inflammasome

Heart attack patients without modifiable risk factors are common and fare better, study finds

Scientists map neural pathways that lead to vomiting after eating contaminated food

Anti-herpes drug can fight against antibiotic-resistant bacterium

UQ spin-off company to develop precision painkillers for treating debilitating conditions

Researchers provide insights on how to overcome resistance in cancer therapy

New method to estimate the contribution of each amino acid residue

Study provides new set of targets for drug therapies to combat chronic inflammatory diseases

Nebulized mRNA-encoded antibodies found to protect hamsters against COVID-19

Industry Focus eBook - Cell biology (5th edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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