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Cross-reactive immunity against coronaviruses

Researchers review the heterologous immunity to coronaviruses and the extent of immune cross-reactivity against SARS-CoV-2.

3 Nov 2021

Pre-clinical follow-up study boosting with original formulation and next generation INO-4802 SARS-CoV-2 vaccine candidate

Researchers describe the antibody-inducing effects of DNA-based synthetic vaccines INO-4800 and INO-4802 against SARS-CoV-2 in non-human primates.

3 Nov 2021

Humoral immunity following heterologous and homologous COVID-19 vaccination regimens

Researchers sought to analyze immune responses after homologous vaccinations or after heterologous Vector/mRNA vaccinations, with respect to anti-COVID-19 immune responses and the development of autoantibodies.

3 Nov 2021

Emerging SARS-CoV-2 variant A.30 efficiently evades vaccine-induced immunity

A recent study published in the journal Cellular & Molecular Immunology shows that a new A.30 variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can evade vaccine-induced antibodies and might spread outside the lungs extraordinarily well, with important implications for our public health response.

1 Nov 2021

Importance of boosters after priming with J&J Ad26.COV2.S COVID-19 vaccine

A new study compares healthcare workers who underwent homologous Ad26.COV2.S booster vaccination to those who underwent heterologous boosting.

28 Oct 2021

Two-dose SARS-CoV-2 vaccine effectiveness against infection and hospitalization in Canada

Authors from varying Canadian institutes report on two-dose vaccine effectiveness against infection and hospitalization.

28 Oct 2021

Immunogenicity and efficacy of heterologous ChadOx1/BNT162b2 vaccination amongst healthcare workers

The heterologous ChAd/BNT combination confers better protection against SARS-CoV-2 infection than the homologous BNT/BNT combination in a real-world observational study of healthcare workers.

27 Oct 2021

Study findings may lead to new treatments to fight deadly C. difficile infections

A University of California, Irvine-led study suggests that the glucosyltransferase domain (GTD) is an ideal molecular target for therapeutic interventions for Clostridioides difficile infection (CDI). These findings may lead to new treatments to fight this deadly disease.

22 Oct 2021

Boosting nonhuman primates with Moderna vaccine increases neutralizing antibody responses

Boosting nonhuman primates with the Moderna vaccine (mRNA-1273) six months after their primary vaccine series increased neutralizing activity against viral variants of concern, a new study shows.

22 Oct 2021

Study shows enhanced immunogenicity of heterologous boosting strategy in individuals primed with J&J vaccine

Researchers from Singapore conducted a study to assess the spike protein-specific humoral and cellular immunity in Ad26.COV2.S vaccinated individuals either primed with Ad26.COV2.S only, or boosted with a homologous or heterologous second dose.

18 Oct 2021

Genetic characteristics of possible new Alphacoronavirus species found in Bats

A recent study identifies a novel Alphacoronavirus isolated from bats, in Korea, in 2020.

13 Oct 2021

New molecular understanding of variations in salmonella virulence

Researchers from the University of Seville, in collaboration with the universities of Zaragoza and Kansas (USA), have managed to describe hitherto unknown processes that allow us to understand the virulence of a Salmonella infection.

11 Oct 2021

Phase I clinical trial of two Cuban recombinant protein COVID-19 vaccines

The results of Phase I clinical trials for two new COVID-19 vaccine candidates based on recombinant RDB proteins are reported.

10 Oct 2021

Mouse brain atlas may help understand the complex circuits of the human brain

The circuits of the human brain contain more than 100 billion neurons, each linked to many other neurons via thousands of synaptic connections, resulting in a three-pound organ that is profoundly more complex than the sum of its innumerable parts.

7 Oct 2021

How durable is the immune response generated from the BNT162b2 vaccine?

In a recent study, researchers analyzed antibody responses to the homologous Wu strain and several other SARS-CoV-2 variants after BNT162b2 vaccination.

4 Oct 2021

Enveloped virus-like particle based vaccines potentially broaden immunity against SARS-CoV-2 variants

A new preprint describes promising results with a novel vaccine candidate designed to improve the breadth of neutralization.

1 Oct 2021

Study finds possible direct connection between neurodegenerative diseases and the herpesvirus

A new study by researchers at University of Illinois Chicago suggests that when the protein optineurin, or OPTN, is present in cells it restricts the spread of HSV-1, the herpes simplex virus type 1.

13 Sep 2021

No evidence of pre-existing antibody and B cell immunity against SARS-CoV-2 in unexposed adults

A group of researchers analyzed the B cell response to SARS-CoV-2 in unexposed individuals.

10 Sep 2021

Researchers say modified COVID-19 vaccine boosters should control pandemic

Researchers in Texas have provided evidence for the need to modify the currently used coronavirus disease 2019 (COVID-19) vaccines to match circulating variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

8 Sep 2021

Uppsala researchers find solution to long-standing biological search enigma

How the cell can mend broken DNA using another DNA copy as template has puzzled researchers for years. How is it possible to find the correct sequences in the busy interior of the cell? Researchers from Uppsala university have now discovered the solution; it is easier to find a rope than a ball if you are blindfolded.

1 Sep 2021

Homologous News and Research

Cross-reactive immunity against coronaviruses

Pre-clinical follow-up study boosting with original formulation and next generation INO-4802 SARS-CoV-2 vaccine candidate

Humoral immunity following heterologous and homologous COVID-19 vaccination regimens

Emerging SARS-CoV-2 variant A.30 efficiently evades vaccine-induced immunity

Importance of boosters after priming with J&J Ad26.COV2.S COVID-19 vaccine

Two-dose SARS-CoV-2 vaccine effectiveness against infection and hospitalization in Canada

Immunogenicity and efficacy of heterologous ChadOx1/BNT162b2 vaccination amongst healthcare workers

Study findings may lead to new treatments to fight deadly C. difficile infections

Boosting nonhuman primates with Moderna vaccine increases neutralizing antibody responses

Study shows enhanced immunogenicity of heterologous boosting strategy in individuals primed with J&J vaccine

Genetic characteristics of possible new Alphacoronavirus species found in Bats

New molecular understanding of variations in salmonella virulence

Phase I clinical trial of two Cuban recombinant protein COVID-19 vaccines

Mouse brain atlas may help understand the complex circuits of the human brain

How durable is the immune response generated from the BNT162b2 vaccine?

Enveloped virus-like particle based vaccines potentially broaden immunity against SARS-CoV-2 variants

Study finds possible direct connection between neurodegenerative diseases and the herpesvirus

No evidence of pre-existing antibody and B cell immunity against SARS-CoV-2 in unexposed adults

Researchers say modified COVID-19 vaccine boosters should control pandemic

Uppsala researchers find solution to long-standing biological search enigma

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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