Inflammatory Disease News and Research

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New computational biology method deciphers gut microbiome ‘chatter’ to fight IBD

Around 500,000 people in the UK live with Inflammatory Bowel Disease (IBD), a life-long, chronic condition characterized by sporadic bouts of gut inflammation causing debilitating symptoms.

14 Mar 2022

Potential molecular and clinical biomarkers of COVID-19 severity

Researchers have reviewed the currently published data examining the potential molecular and clinical biomarkers of COVID-19 severity.

4 Mar 2022

Covid still threatens millions of Americans. Why are we so eager to move on?

Iesha White is so fed up with the U.S. response to covid-19 that she's seriously considering moving to Europe.

22 Feb 2022

Twin study identifies the influence of environment and genetics in multiple sclerosis

Researchers at the University of Zurich and Munich's LMU Klinikum hospital have studied the immune system of pairs of monozygotic twins to identify the influence of the environment and of genetics in cases of multiple sclerosis.

16 Feb 2022

USF receives NIH Training Grant to prepare next generation of translational researchers

The University of South Florida recently received a highly competitive National Institutes of Health Institutional Training Grant (Award Number T32HL160529), boosting the USF Health Morsani College of Medicine's capacity to prepare the next generation of scientists in an emerging area of research applicable to many major diseases.

4 Feb 2022

Research supports the need for a 3rd mRNA COVID vaccine in patients taking immunosuppressants

New research posted to the medRxiv* preprint server finds patients with immune-mediated inflammatory diseases undergoing anti-TNF therapy had the greatest reduction of antibody levels three months after vaccination. In addition, they had weaker neutralization responses towards severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern.

1 Feb 2022

Link established between gut microbiota and chronic inflammatory diseases

An international research team has established a link between gut microbiota and chronic inflammatory diseases such as arthritis.

25 Jan 2022

Multiple sclerosis may be caused by infection with the Epstein-Barr virus

Multiple sclerosis (MS), a progressive disease that affects 2.8 million people worldwide and for which there is no definitive cure, is likely caused by infection with the Epstein-Barr virus (EBV), according to a study led by Harvard T.H. Chan School of Public Health researchers.

13 Jan 2022

Study finds a subset of vascular macrophages to be powerful ally in the fight against atherosclerosis

A new study reveals the existence of a powerful ally in the fight against cardiovascular disease, a protective subset of vascular macrophages expressing the C-type lectin receptor CLEC4A2, a molecule which fosters "good" macrophage behavior within the vessel wall.

11 Jan 2022

A new approach for drugs to be more effective against inflammatory bowel disease

Biomedical scientists at the University of California, Riverside, propose a way for drugs to be more effective against inflammatory bowel disease, or IBD, in which the intestine undergoes inflammation.

18 Dec 2021

Study identifies several proteins that protect against disease development

Inflammatory processes are associated with a large range of human diseases, including rheumatic diseases and allergies. Protein biomarkers are measurable molecules that can have a prognostic value in patients, be used to diagnose disease, or indicate severity of disease.

8 Dec 2021

An analysis of risk factors and symptom presentation among groups at risk for SARS-CoV-2 infection

The study, published on the pre-print server medRxiv*, analyzed the specific linkages between the COVID-19 patients belonging to the three risk groups with the overall COVID-19 patients and compared symptoms between and within the risk groups.

6 Dec 2021

Novel anti-inflammatory drug target identified by CRISPR

In this interview, News-Medical speaks to Dr. Jeffrey Rathmell about his recent research into how metabolic pathways impact immune function.

1 Dec 2021

RA patients taking glucocorticoids or B-cell therapies may have worse COVID-19 vaccine response

New research presented this week at ACR Convergence, the American College of Rheumatology's annual meeting, shows that people with chronic inflammatory diseases, such as rheumatoid arthritis (RA), who take immunosuppressive therapy appear to have an impaired immunity response to SARS-CoV-2, the coronavirus that causes COVID-19, vaccines. Patients currently on glucocorticoids or B-cell depleting therapy appear to have an even more severely impeded vaccine response.

2 Nov 2021

Innovative artificial neural network can accurately detect radiographic sacroiliitis

New research presented this week at ACR Convergence, the American College of Rheumatology's annual meeting, found that an innovative new artificial neural network can detect radiographic sacroiliitis in patients with suspected axial spondyloarthritis, a progressive disease that is more common in young adults.

2 Nov 2021

COVID-19 and subacute neuropsychiatric symptoms in adolescents

A new paper discusses neurologic symptoms in children with COVID-19.

27 Oct 2021

Improper Z-RNA recognition contributes to pathogenesis of Aicardi-Goutières syndrome

Like DNA, RNA molecules contain information through unique combinations of four different nucleotides. However, through a molecular process called RNA editing, chemical changes can be made to adenosine nucleotides that convert them to a nucleotide called inosine by enzymes known as adenosine deaminases (ADARs).

21 Oct 2021

Study shows how tissue-derived T cells can damage other organs in stem cell transplant patients

More than 40,000 allogeneic hematopoietic stem cell transplants are carried out worldwide every year, mostly for patients suffering from leukemia or other diseases of the hematopoietic system.

13 Oct 2021

Better clinical outcomes in COVID-19 and vaccine-related myocarditis than classic myocarditis in children

Researchers have investigated the differences between 'classic' myocarditis, COVID-19 induced myocarditis, and vaccine-related myocarditis.

11 Oct 2021

Primary sclerosing cholangitis: Therapy with synthetic bile acid acts directly on the immune system

Primary Sclerosing Cholangitis (PSC) is a rare, chronic inflammatory disease of the bile ducts and is difficult to treat. Studies conducted by the Division of Gastroenterology and Hepatology at MedUni Wien under the guidance of Michael Trauner (Department of Internal Medicine III) were able to show positive effects from the administration of synthetically produced bile acids and bile acid receptor agonists.

28 Sep 2021