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Transforming growth factor beta inhibition boosts NK cell therapy against hepatocellular carcinoma

Researchers at University of California San Diego have found that the most common form of liver cancer - one with a high mortality rate - can be better targeted and treated using an innovative new stem cell-derived therapy, according to a recently published study in Cell Stem Cell.

9 Jul 2024

Blocking nidogen-2 enhances chemotherapy efficacy in pancreatic cancer

Researchers at the Garvan Institute of Medical Research have identified a potential new therapeutic target for pancreatic cancer, one of the most lethal cancer types with limited treatment options.

9 Jul 2024

GLP-1 drugs found to lower cancer risk in diabetes patients

Research finds that GLP-1 receptor agonists significantly reduce the risk of 10 out of 13 obesity-associated cancers in type 2 diabetes patients compared to insulins, but show varied results against metformin.

8 Jul 2024

Research reveals immune suppression link between cancer and pregnancy

To understand why some cancers successfully circumvent the immune system to grow unchecked, researchers turned to pregnancy.

8 Jul 2024

Blocking IL-6 in the brain to treat cancer cachexia

Cancer is insidious. Throughout tumor progression, the disease hijacks otherwise healthy biological processes - like the body's immune response - to grow and spread.

8 Jul 2024

Small molecule discovery offers hope for treatment of Angelman syndrome

Angelman syndrome is a rare genetic disorder caused by mutations in the maternally-inherited UBE3A gene and characterized by poor muscle control, limited speech, epilepsy, and intellectual disabilities.

8 Jul 2024

Scientists identify over 5000 high-risk cancer gene variants

Over 5,000 genetic variants that enable certain cancers to thrive have been identified by scientists, along with a potential therapeutic target to treat or even prevent these cancers from developing.

8 Jul 2024

Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment

Insilico Medicine("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, has successfully delivered the second preclinical candidate compound (PCC) in its collaboration with Fosun Pharma in June 2024, a potential innovative therapeutic using synthetic lethal strategy for the treatment of solid tumors.

5 Jul 2024

Scientists map all the possible outcomes of changes to key tumor-suppressing gene

Researchers at the Francis Crick Institute have mapped all the possible outcomes of changes to a tumor-suppressing gene called VHL, the first step in a huge research endeavor to unpick the outcomes of tens of thousands of genetic variations in genes associated with cancer.

5 Jul 2024

DNA repair mutations act as a switch for bowel cancer

Bowel cancer cells have the ability to regulate their growth using a genetic on-off switch to maximize their chances of survival, a phenomenon that's been observed for the first time by researchers at UCL and University Medical Center Utrecht.

5 Jul 2024

Stanford researchers uncover key to overcoming chemoresistance in pancreatic cancer

Pancreatic cancer is a particularly aggressive and difficult-to-treat cancer, in part because it is often resistant to chemotherapy.

4 Jul 2024

Turning cancer cells against themselves to overcome drug resistance

Treating cancer can sometimes feel like a game of Whac-A-Mole. The disease can become resistant to treatment, and clinicians never know when, where and what resistance might emerge, leaving them one step behind.

4 Jul 2024

Repurposing cancer drug to prevent organ damage in infectious diseases

Twelve years ago, cancer researchers at University of California San Diego identified a molecule that helps cancer cells survive by shuttling damaging inflammatory cells into tumor tissue.

3 Jul 2024

Exercise boosts tumor-killing white blood cells in breast cancer patients

A new Finnish study from University of Turku shows that already a 30-minute exercise can increase the proportion of tumor-killing white blood cells in the bloodstream of breast cancer patients.

3 Jul 2024

White blood cell type identified as important contributor to inflammation in obesity

Researchers explored neutrophil involvement in visceral adipose tissue (VAT) inflammation in obesity.

3 Jul 2024

RNA splicing modulation as a precision approach for neuroendocrine cancer treatment

Neuroendocrine tumors, including small cell lung cancer and neuroendocrine prostate cancer, are very aggressive with high chances of spreading.

2 Jul 2024

AI uncovers potential cancer drivers hidden in 'junk' regions of DNA

Using artificial intelligence, Garvan Institute researchers have found potential cancer drivers hidden in so-called 'junk' regions of DNA, opening up possibilities for a new approach to diagnosis and treatment.

2 Jul 2024

Novel mathematical approach reveals shared gene programs in anti-tumor CD8+ T cells

We set out to identify genes that are commonly expressed in CD8+ T cells, killer immune cells that can drive anti-tumor immunity, across many types of human cancers.

2 Jul 2024

Frequent infections and pathobionts boost children's nasal immunity, study reveals

Dynamic interactions with viruses and bacterial pathobionts significantly enhance nasal innate immunity in children, revealing distinct immunophenotypes driven by microbial load and type.

2 Jul 2024

Mediterranean diet linked to enhanced longevity, reduced cardiovascular mortality in cancer survivors

The Mediterranean Diet is a powerful ally for health even after a cancer diagnosis. This is the key result of an Italian study carried out as part of the UMBERTO Project, conducted by the Joint Research Platform Umberto Veronesi Foundation - Department of Epidemiology and Prevention of the I.R.C.C.S. Neuromed of Pozzilli, in collaboration with the LUM "Giuseppe Degennaro" University of Casamassima (BA).

2 Jul 2024

Tumor News and Research

Transforming growth factor beta inhibition boosts NK cell therapy against hepatocellular carcinoma

Blocking nidogen-2 enhances chemotherapy efficacy in pancreatic cancer

GLP-1 drugs found to lower cancer risk in diabetes patients

Research reveals immune suppression link between cancer and pregnancy

Blocking IL-6 in the brain to treat cancer cachexia

Small molecule discovery offers hope for treatment of Angelman syndrome

Scientists identify over 5000 high-risk cancer gene variants

Insilico Medicine and Fosun Pharma deliver second preclinical candidate for solid tumor treatment

Scientists map all the possible outcomes of changes to key tumor-suppressing gene

DNA repair mutations act as a switch for bowel cancer

Stanford researchers uncover key to overcoming chemoresistance in pancreatic cancer

Turning cancer cells against themselves to overcome drug resistance

Repurposing cancer drug to prevent organ damage in infectious diseases

Exercise boosts tumor-killing white blood cells in breast cancer patients

White blood cell type identified as important contributor to inflammation in obesity

RNA splicing modulation as a precision approach for neuroendocrine cancer treatment

AI uncovers potential cancer drivers hidden in 'junk' regions of DNA

Novel mathematical approach reveals shared gene programs in anti-tumor CD8+ T cells

Frequent infections and pathobionts boost children's nasal immunity, study reveals

Mediterranean diet linked to enhanced longevity, reduced cardiovascular mortality in cancer survivors

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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