Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Alzheimer’s drug targets people with mild cognitive impairment. What does that mean?

The approval of a controversial new drug for Alzheimer's disease, Aduhelm, is shining a spotlight on mild cognitive impairment — problems with memory, attention, language or other cognitive tasks that exceed changes expected with normal aging.

29 Sep 2021

Patient-specific whole-heart computational models provide insights for personalized treatment

Whole-heart ventricular modeling has come a long way in recent years and is currently witnessing the evolution of a variety of computational approaches, especially within the realm of personalized technologies for patient-specific clinical applications.

29 Sep 2021

Researchers develop new mouse model for studying non-Demented with Alzheimer’s disease

Alzheimer's is a neurodegenerative disease that features the accumulation of the beta-amyloid peptide and Tau protein in the brain, which are associated with deficits in the neuronal connections and with dementia.

28 Sep 2021

Exposure to smoking and mutations in blood cells may lead to a rare cancer that affects immune cells

Mutations in blood cells likely caused by smoking and aging-related changes may lead to a rare type of blood cancer that affects immune cells, shows a study published today in eLife.

28 Sep 2021

Mass Eye and Ear researcher receives P50 NIH grant to establish new center for neurological voice disorders

Kristina Simonyan, MD, PhD, Dr med, director of laryngology research at Mass Eye and Ear, has been awarded an $11.9 million P50 Clinical Research Center Grant from the National Institute on Deafness and Other Communicable Disorders of the National Institute of Health to form a new multidisciplinary center across four academic medical institutions that will be committed to conducting research on laryngeal dystonia and voice tremor, two debilitating neurological voice disorders.

28 Sep 2021

Caspase-11 identified as regulator of inflammatory pathology in SARS-CoV-2 infections

New findings identify CASP4/11 as detrimental to inflammation and coagulopathy associated with SARS-CoV-2 infection.

28 Sep 2021

Researchers release guidance to address pathology aspects in clinical trial protocols

An international group of cancer researchers, led by the National Cancer Research Institute's (NCRI) Cellular Molecular Pathology Initiative (CMPath), has published guidance to address the variability in how pathology is planned and delivered in clinical trials.

28 Sep 2021

Researchers discover protein previously unknown to be involved in SARS-CoV-2 infection

Researchers in the UK and Germany have provided evidence for a novel mechanism by which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – binds to human host cells.

27 Sep 2021

Researchers discover how Rift Valley fever virus enters cells

Rift Valley fever virus causes economically devastating outbreaks of hemorrhagic fever in livestock such as sheep, goats and cattle.

24 Sep 2021

Scientists discover how mucus protein emerges to disrupt airways of individuals with lung conditions

Mucus is an essential protective layer of gel-like liquid composed largely of proteins called mucins throughout our airways. One of them, called MUC5B, is crucial for the innate defense against the various things we inhale.

23 Sep 2021

Study provides novel insights into how KLF4 influences gene expression

A team led by researchers at Baylor College of Medicine has discovered a mechanism by which transcription factor KLF4 can help to organize chromatin, thus influencing gene expression.

23 Sep 2021

Penn Medicine and Wistar secure $11.7 million SPORE grant for three melanoma research projects

Penn Medicine and The Wistar Institute have been awarded a prestigious $11.7 million Specialized Programs of Research Excellence, or SPORE, grant from the National Cancer Institute.

22 Sep 2021

MIND diet may benefit older adults, research shows

Aging takes a toll on the body and on the mind. For example, the tissue of aging human brains sometimes develops abnormal clumps of proteins that are the hallmark of Alzheimer's disease.

22 Sep 2021

Revival of the cell and gene therapy field opens new avenues for repairing the Parkinsonian brain

After several decades of pre-clinical development, cell- and gene-based therapies for Parkinson's disease (PD) are now actively being explored.

21 Sep 2021

Artificial intelligence predicts the risk of metastatic relapse in breast cancer patients

The RACE AI study conducted by Gustave Roussy and the startup Owkin, as part of the AI for Health Challenge organized by the Ile-de-France Region in 2019, was presented as a proffered paper at ESMO.

21 Sep 2021

Nasal drugs show success in slowing Parkinson's disease progression in mice

Potential new treatments for Parkinson's disease developed by researchers at Rush University Medical Center have shown success in slowing progression of the disease in mice.

21 Sep 2021

Changes in fibrin clot structure contributes to thrombosis risk in severe COVID-19

Researchers from Europe recently demonstrated altered levels of factor XII (FXII) and its activation products in 2 independent cohorts of critically ill patients with COVID-19 compared to patients suffering from severe acute respiratory distress syndrome caused by the influenza virus (acute respiratory distress syndrome (ARDS)-influenza).

21 Sep 2021

Research could lead to new treatment option for breast cancer patients with brain metastases

Breast cancer patients whose cancer spreads to the brain may soon have new treatment options, thanks to research led by CU Cancer Center member Diana Cittelly, PhD.

21 Sep 2021

Large scale 'proteogenomics' study could offer hope to patients with deadly pancreatic cancer

A large international collaboration led by researchers from the Johns Hopkins Kimmel Cancer Center has identified promising new targets for pancreatic cancer treatment and early diagnosis after examining various aspects of these tumors' genes and proteins.

20 Sep 2021

COVID-19 vaccine-related allergies are rare, typically mild and treatable, finds study

Allergic reactions to the new mRNA-based COVID-19 vaccines are rare, typically mild and treatable, and they should not deter people from becoming vaccinated, according to research from the Stanford University School of Medicine.

20 Sep 2021

Pathology News and Research

Further Reading

Alzheimer’s drug targets people with mild cognitive impairment. What does that mean?

Patient-specific whole-heart computational models provide insights for personalized treatment

Researchers develop new mouse model for studying non-Demented with Alzheimer’s disease

Exposure to smoking and mutations in blood cells may lead to a rare cancer that affects immune cells

Mass Eye and Ear researcher receives P50 NIH grant to establish new center for neurological voice disorders

Caspase-11 identified as regulator of inflammatory pathology in SARS-CoV-2 infections

Researchers release guidance to address pathology aspects in clinical trial protocols

Researchers discover protein previously unknown to be involved in SARS-CoV-2 infection

Researchers discover how Rift Valley fever virus enters cells

Scientists discover how mucus protein emerges to disrupt airways of individuals with lung conditions

Study provides novel insights into how KLF4 influences gene expression

Penn Medicine and Wistar secure $11.7 million SPORE grant for three melanoma research projects

MIND diet may benefit older adults, research shows

Revival of the cell and gene therapy field opens new avenues for repairing the Parkinsonian brain

Artificial intelligence predicts the risk of metastatic relapse in breast cancer patients

Nasal drugs show success in slowing Parkinson's disease progression in mice

Changes in fibrin clot structure contributes to thrombosis risk in severe COVID-19

Research could lead to new treatment option for breast cancer patients with brain metastases

Large scale 'proteogenomics' study could offer hope to patients with deadly pancreatic cancer

COVID-19 vaccine-related allergies are rare, typically mild and treatable, finds study

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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