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Scientists identify new antibiotic substances in Russian Brown frog's skin

Following up on an ancient Russian way of keeping milk from going sour - by putting a frog in the bucket of milk - scientists have identified a wealth of new antibiotic substances in the skin of the Russian Brown frog. The study appears in ACS' Journal of Proteome Research.

13 Dec 2012

Unigene announces results from oral PTH Phase 2 study on osteoporosis

Unigene Laboratories, Inc., a leader in the design, delivery, manufacture and development of peptide-based therapeutics, today announced that the results of its successful Phase 2 clinical trial evaluating an experimental oral parathyroid hormone (PTH) analog for the treatment of osteoporosis in postmenopausal women has been published online by Bone, the Official Journal of the International Bone and Mineral Society.

13 Dec 2012

Bicycle Therapeutics secures £3.75 million equity financing for drug discovery

Bicycle Therapeutics, a next generation biotherapeutics company co-founded by Sir Gregory Winter and Professor Christian Heinis, today announced that it had secured a tranched equity financing of £3.75 million to invest in selection of drug candidates using its bicyclic peptide technology platform.

10 Dec 2012

DOW Chemical to attend the 4th World Drug Delivery & Formulation Summit

The pharmaceutical industry is experiencing a massive paradigm shift as the era of the highly profitable blockbusters comes to a close. In an attempt to remain competitive, companies are under more pressure than ever to push novel compounds through the development pipeline and so it has been largely left to those in formulation and delivery to optimise their product portfolio using winning business strategies and leading technologies.

10 Dec 2012

BlueGenics aims to discover new drugs from deep sea to combat osteoporosis

Searching for substances from the deep sea to combat osteoporosis and other human common diseases is one of the objectives of the new European research project "BlueGenics" which has received funding of EUR 6 million from the European Commission.

10 Dec 2012

Targeting RAD52 protein can block the process by which leukemia stem cells repair themselves

Despite treatment with imatinib, a successful drug that targets chronic myeloid leukemia (CML), a deadly type of cancer, some patients may continue to be at risk for relapse because a tiny pool of stem cells is resistant to treatment and may even accumulate additional genetic aberrations, eventually leading to disease progression and relapse. These leukemia stem cells are full of genetic errors, loaded with potentially lethal breaks in DNA, and are in a state of constant self-repair.

10 Dec 2012

Novel antidepressant targets brain receptors responsible for learning and memory

A first-of-its-kind antidepressant drug discovered by a Northwestern University professor and now tested on adults who have failed other antidepressant therapies has been shown to alleviate symptoms within hours, have good safety and produce positive effects that last for about seven days from a single dose.

7 Dec 2012

Drug offers alternative treatment strategy for insomnia

Orexin receptor antagonism may offer a novel treatment approach to insomnia, clinical findings suggest.

7 Dec 2012

ASU scientists use X-ray laser to reveal 3-D structure of cathepsin B enzyme

An international team of scientists, using the world's most powerful X-ray laser, has revealed the three dimensional structure of a key enzyme that enables the single-celled parasite that causes African trypanosomiasis (or sleeping sickness) in humans.

6 Dec 2012

NOXXON commences NOX-H94 Phase IIa trial to treat anemia of chronic disease

NOXXON Pharma today announced the treatment of the first patients in a Phase IIa clinical trial of its anti-hepcidin Spiegelmer NOX-H94 to treat anemia associated with chronic disease.

5 Dec 2012

Pain can be treated by targeting immune and nerve cells outside brain or spinal cord

The treatment of inflammatory pain can be improved by endogenous opioid peptides acting directly in injured tissue. Scientists at the Charité - Universitätsmedizin Berlin and the Université Paris Descartes showed that pain can be successfully treated by targeting immune and nerve cells outside the brain or spinal cord.

3 Dec 2012

Researchers study antimicrobial peptides in fish gills to find solution for blocking human infections

Living in an environment teaming with bacteria and fungi, fish have evolved powerful defenses against waterborne pathogens, including antimicrobial peptides located in their gills. Undergraduate researchers at Worcester Polytechnic Institute are studying the biology and the mechanics of one of those peptides with the hope they can use that knowledge to create engineered surfaces that kill bacteria responsible for foodborne illnesses and hospital-acquired infections.

1 Dec 2012

NAP and SAL injection during pregnancy improve memory, learning tasks in offsprings

Mice with a condition that serves as a laboratory model for Down syndrome perform better on memory and learning tasks as adults if they were treated before birth with neuroprotective peptides, according to researchers at the National Institutes of Health.

30 Nov 2012

Membrane-proximal external region of HIV could be used to design vaccines

Beatriz Apellaniz, PhD holder of the UPV/EHU-University of the Basque Country, has studied in her PhD thesis HIV regions that could be used to design a vaccine. The researcher has focussed her research on a specific region of the surface protein of the Human Immunodeficiency Virus (HIV), which is responsible for the Autoimmune Deficiency Syndrome (AIDS), one of the diseases with the greatest human morbidity and mortality.

30 Nov 2012

Rhythm raises additional $8 million to complete Series B financing

Rhythm announced today that the company has raised an additional $8 million to complete a $33 million Series B financing.

27 Nov 2012

Moderate exercise protects elderly hearts

The more exercise taken by individuals aged 65 years and older, the less likely biomarkers indicative of cardiac injury and new-onset heart failure are to increase, show US study findings.

26 Nov 2012

Somnogen induces sleep in patients with primary hypersomnia

Researchers at Emory University School of Medicine have discovered that dozens of adults with an elevated need for sleep have a substance in their cerebrospinal fluid that acts like a sleeping pill.

22 Nov 2012

Study: 2-PMPA improves cognition in mice with MS

Johns Hopkins researchers report the successful use of a form of MRI to identify what appears to be a key biochemical marker for cognitive impairment in the brains of people with multiple sclerosis (MS). In follow-up experiments on mice with a rodent form of MS, researchers were able to use an experimental compound to manipulate that same marker and dramatically improve learning and memory.

21 Nov 2012

New polymer-based system to fight infection, filter water and heal wounds

Working in the lab for the last few years, three generations of University of Akron polymer scientists say their mutual and passionate curiosity about science has led to their discovery of a first-of-its-kind, easily adaptable biocompatible polymer structure able to fight infection, filter water and perform a host of other functions.

20 Nov 2012

UBC microbiologist receives Prix Galien 2012 Research Award

UBC microbiologist Robert E.W. Hancock has received the Prix Galien 2012 Research Award, widely considered the most prestigious honour in Canadian pharmaceutical research and innovation. Hancock is being recognized for pioneering work unravelling the complex interactions between antibiotics and bacteria.

20 Nov 2012