Clinical Trial News and Research

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UCL researchers develop new gene therapy to cure severe childhood epilepsy

UCL researchers have developed a new gene therapy to cure a devastating form of childhood epilepsy, which a new study shows can significantly reduce seizures in mice.

14 Dec 2023

Researchers identify the culprit responsible for harmful inflammation in certain muscular disorders

Inflammation is an important part of the body's defenses, eliminating threats and repairing damage. When the immune system is overactivated, though, it can turn from friend to foe.

14 Dec 2023

Atezolizumab plus carboplatin: A winning combination for metastatic triple-negative breast cancer

Immunotherapy in combination with chemotherapy has become an important therapeutic treatment option in some patients with metastatic breast cancer.

14 Dec 2023

Common oral anticoagulant rivaroxaban linked to highest risk of bleeding complications

When diagnosed with a blood clot or atrial fibrillation, patients are often prescribed anticoagulants, or blood thinners, to prevent a future clot.

14 Dec 2023

Research shows correlation between neonatal proteins and adult health

Research led by Professor John McGrath from the University of Queensland found that the concentration of the C4 protein, an important part of the immune system, was not associated with risk of mental disorders.

13 Dec 2023

Scientists unlock secret to repairing malnourished children's guts

A clinical trial reported in 2021 and conducted by a team of researchers from Washington University School of Medicine in St. Louis and the International Centre for Diarrhoeal Disease Research in Dhaka, Bangladesh, showed that a newly designed therapeutic food aimed at repairing malnourished children's underdeveloped gut microbiomes was superior to a widely used standard therapeutic food.

13 Dec 2023

Weill Cornell Medicine joins PICI network for collaborative cancer research effort

The Parker Institute for Cancer Immunotherapy (PICI), the largest concentration of immuno-oncology (IO) expertise in the world, announced it has added Weill Cornell Medicine to its network of preeminent academic and medical research institutions at the forefront of the fight against cancer.

13 Dec 2023

Targeting cholesterol metabolism for the treatment of serrated colorectal neoplasms

Hard-to-detect colorectal pre-cancerous lesions known as serrated polyps, and the aggressive tumors that develop from them, depend heavily on the ramped-up production of cholesterol, according to a preclinical study from researchers at Weill Cornell Medicine.

13 Dec 2023

UK Aid awards funding to Oxford Vaccine Group for research into prevention of five epidemic threats

Oxford Vaccine Group (OVG), which led the rapid clinical development of the Oxford vaccine in COVID-19 in the pandemic, has been awarded a total of £7,788,783 by UK Aid for research into the prevention of five dangerous diseases with epidemic or pandemic potential.

13 Dec 2023

Stem cell therapy trial shows promise for regenerative treatment of heart failure

Stem cell-based therapy improved quality of life for patients with advanced heart failure, Mayo Clinic researchers and international collaborators discovered in a late-stage multinational clinical trial.

12 Dec 2023

RBD-focused vaccines may offer broader protection against emerging COVID-19 variants

Published in The Lancet's eBioMedicine, 76 healthy adults from Melbourne, aged 18 to 64 who were previously vaccinated with licensed SARS-CoV-2 vaccines, were randomized to receive a fourth dose of a novel protein vaccine, mRNA vaccine or placebo.

12 Dec 2023

Liquid biopsy may offer new tools for personalized immunotherapy in lung cancer

Using a "liquid biopsy" to study genetic material from tumors shed into the bloodstream together with immune cells could help clinicians predict which patients with advanced lung cancers are responding to immunotherapies and which patients may develop immune-related side effects several months later, according to research directed by investigators at the Johns Hopkins Kimmel Cancer Center, the Bloomberg~Kimmel Institute for Cancer Immunotherapy and Allegheny Health Network Cancer Institute in Pittsburgh.

12 Dec 2023

Daily consumption of prunes may reduce inflammation markers and bone loss effects

A new study published in The Journal of Nutrition shows daily consumption of prunes may reduce inflammation markers connected to bone signaling pathways and reduce the effects of bone loss among postmenopausal women.

12 Dec 2023

New study unlocks hope for immunotherapy in metastatic prostate cancer

Immunotherapy has been disappointing as a prostate cancer treatment, but a new Columbia study suggests that the powerful treatments have potential when the disease starts to spread.

12 Dec 2023

SolasCure demonstrates proof-of-concept in Phase lla safety trial of Aurase Wound Gel

SolasCure today announced the results of its proof-of-concept, first-in-human, Phase IIa safety study.

From SolasCure 12 Dec 2023

New optimized vaccine approach targets Hepatitis C virus variability

A method to design vaccines for highly variable viruses like the hepatitis C virus.

12 Dec 2023

New antibody combination shows 'surprising' results in high-risk follicular lymphoma trial

Researchers conducting a Phase 2 clinical trial at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine say a new combination of antibody therapies produced a 'surprisingly high' response rate in patients with high-risk follicular lymphoma, a type of non-Hodgkin lymphoma.

11 Dec 2023

Tirzepatide maintains weight loss and improves cardiometabolic health in SURMOUNT-4 trial

The current class of anti-obesity drugs is proving remarkably effective at removing excess pounds. However, a phase 3 randomized clinical trial led by researchers at Weill Cornell Medicine and NewYork-Presbyterian found that people who stopped taking the medication regained much of that weight within a year.

11 Dec 2023

Double punch for B-cell lymphomas: CAR T-cell innovation boosts efficacy, cuts toxicity

The Malaghan Institute of Medical Research in collaboration with Wellington Zhaotai Therapies Limited today announced results of its phase 1 dose escalation trial of a new third-generation anti-CD19 chimeric antigen receptor (CAR) T-cell therapy to be presented at the American Society of Hematology (ASH) Annual Meeting in San Diego on 11 December, 3pm.

11 Dec 2023

Ketogenic diet proved to be effective at controlling polycystic kidney disease

It's official: The ketogenic diet proved to be effective at controlling polycystic kidney disease (PKD) in the first randomized controlled clinical trial of ketogenic metabolic therapy for PKD.

11 Dec 2023

Clinical Trial News and Research

UCL researchers develop new gene therapy to cure severe childhood epilepsy

Researchers identify the culprit responsible for harmful inflammation in certain muscular disorders

Atezolizumab plus carboplatin: A winning combination for metastatic triple-negative breast cancer

Common oral anticoagulant rivaroxaban linked to highest risk of bleeding complications

Research shows correlation between neonatal proteins and adult health

Scientists unlock secret to repairing malnourished children's guts

Weill Cornell Medicine joins PICI network for collaborative cancer research effort

Targeting cholesterol metabolism for the treatment of serrated colorectal neoplasms

UK Aid awards funding to Oxford Vaccine Group for research into prevention of five epidemic threats

Stem cell therapy trial shows promise for regenerative treatment of heart failure

RBD-focused vaccines may offer broader protection against emerging COVID-19 variants

Liquid biopsy may offer new tools for personalized immunotherapy in lung cancer

Daily consumption of prunes may reduce inflammation markers and bone loss effects

New study unlocks hope for immunotherapy in metastatic prostate cancer

SolasCure demonstrates proof-of-concept in Phase lla safety trial of Aurase Wound Gel

New optimized vaccine approach targets Hepatitis C virus variability

New antibody combination shows 'surprising' results in high-risk follicular lymphoma trial

Tirzepatide maintains weight loss and improves cardiometabolic health in SURMOUNT-4 trial

Double punch for B-cell lymphomas: CAR T-cell innovation boosts efficacy, cuts toxicity

Ketogenic diet proved to be effective at controlling polycystic kidney disease

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