Preclinical News and Research

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New review of post-acute COVID-19

The first year of the COVID-19 pandemic has taken the lives of millions of people around the world but has also left hundreds with lingering symptoms or completely new symptoms weeks after recovery.

23 Mar 2021

New treatment for late-stage neuroendocrine tumors found to be more effective and less toxic

A new treatment for late-stage neuroendocrine tumors (NETs) has been found to be more effective and have fewer side effects than the current standard of care, according to research published in the March issue of The Journal of Nuclear Medicine.

22 Mar 2021

RedHill provides opaganib treatment under compassionate use exemption for Swiss COVID-19 patients

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced that it has acted on a request to provide opaganib treatment on an outpatient basis under compassionate use exemption for several Swiss patients suffering from COVID-19 pneumonia.

22 Mar 2021

Anti-androgen drugs may help disarm coronavirus spike protein, stop progression of COVID-19

Hormone drugs that reduce androgen levels may help disarm the coronavirus spike protein used to infect cells and stop the progression of severe COVID-19 disease, suggests a new preclinical study from researchers in the Abramson Cancer Center at the University of Pennsylvania and published online in Cell Press's iScience.

22 Mar 2021

Researchers test novel gene regulation approach to treat brain diseases

Researchers at the DZNE (Germany), at Massachusetts General Hospital (USA) and at the genomic medicine company Sangamo Therapeutics, Inc. tested a novel gene regulation approach to treat brain diseases such as Alzheimer's in laboratory studies.

22 Mar 2021

NYSCF is developing new stem cell therapy to treat age-related macular degeneration

The New York Stem Cell Foundation (NYSCF) today announced that they are developing a stem cell therapy to treat patients suffering from age-related macular degeneration (AMD).

22 Mar 2021

Circular RNA vaccine shows neutralizing activity against B.1.351 variant

New preclinical research led by Wensheng Wei from Peking University in China has proposed the development of a circular RNA vaccine. Their findings showed the circular RNA vaccine creates neutralizing antibodies and strong T-cell responses against the receptor-binding domain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein.

21 Mar 2021

Novel form of polymerized estrogen could provide neuroprotection

A novel form of polymerized estrogen developed at Rensselaer Polytechnic Institute can provide neuroprotection when implanted at the site of a spinal cord injury -- preventing further damage.

20 Mar 2021

VHIO-born spin-off receives approval to initiate Phase I/II clinical trial of novel Myc inhibitor

Co-founded back in 2014 by VHIO's Laura Soucek, CEO of the enterprise, and Marie-Eve Beaulieu, Chief Scientific Officer (CSO) of the company, VHIO-born spin-off Peptomyc S.L. has just announced that it has received approval from the Spanish Agency of Medicines and Medical Devices for conducting clinical trials in Spain (AEMPS), to initiate the first-in-human Phase I/II clinical trial with its first compound - a disruptive Myc inhibitor, Omomyc (OMO-103).

19 Mar 2021

New antibiotic compound can effectively clear multi-drug resistant gonorrhea in animals

A new antibiotic compound clears infection of multi-drug resistant gonorrhea in mice in a single oral dose, according to a new study led by researchers at Penn State and Emory University.

19 Mar 2021

Anti-SARS-CoV-2 drug candidate enters phase I clinical trial

DC402234 (FB2001), an anti-SARS-CoV-2 drug candidate mainly developed by research team at the Shanghai Institute of Materia Medica (SIMM) of Chinese Academy of Sciences enters its Phase I clinical trial in the United States on March 15.

19 Mar 2021

Anti-inflammatory therapies may help prevent heart disease in people with age-related blood condition

Therapies that soothe inflammation could be an effective way to prevent heart disease in people with a common age-related blood condition, according to a new study from researchers at Columbia University Vagelos College of Physicians and Surgeons.

18 Mar 2021

Progesterone therapy may improve clinical outcomes for male COVID-19 patients

COVID-19 disproportionately affects men compared with women, raising the possibility that a hormone like progesterone may improve clinical outcomes for certain hospitalized men with the disease.

18 Mar 2021

Novel cancer-fighting gene therapy enters phase I clinical trial

Researchers from the MDC and Charité have developed a new gene therapy based around a special T-cell receptor that helps the immune system effectively recognize and fight cancer cells.

18 Mar 2021

Novel protein construct prevents lethal COVID-19 in mice

Researchers in the United States have developed a novel protein that prevented lethal disease among mice infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

16 Mar 2021

Investigating Food Fraud in the Honey Industry

In this interview, News-Medical talks to Ron Phipps about food fraud within the honey industry and the methods for investigating it.

From Bruker BioSpin Group 16 Mar 2021

New Phase 1 study evaluates prime/boost HIV-1 vaccine formulated with combinations of adjuvants

A new Phase 1 vaccine study began today that will evaluate experimental prime/boost HIV-1 vaccine regimens formulated with combinations of different adjuvants, including one from the Army Liposome Formulation (ALF) family of adjuvants developed by scientists with the U.S. Military HIV Research Program at the Walter Reed Army Institute of Research.

15 Mar 2021

Preclinical News and Research

New review of post-acute COVID-19

New treatment for late-stage neuroendocrine tumors found to be more effective and less toxic

RedHill provides opaganib treatment under compassionate use exemption for Swiss COVID-19 patients

Anti-androgen drugs may help disarm coronavirus spike protein, stop progression of COVID-19

Researchers test novel gene regulation approach to treat brain diseases

NYSCF is developing new stem cell therapy to treat age-related macular degeneration

Circular RNA vaccine shows neutralizing activity against B.1.351 variant

Novel form of polymerized estrogen could provide neuroprotection

VHIO-born spin-off receives approval to initiate Phase I/II clinical trial of novel Myc inhibitor

New antibiotic compound can effectively clear multi-drug resistant gonorrhea in animals

Anti-SARS-CoV-2 drug candidate enters phase I clinical trial

Anti-inflammatory therapies may help prevent heart disease in people with age-related blood condition

Progesterone therapy may improve clinical outcomes for male COVID-19 patients

Novel cancer-fighting gene therapy enters phase I clinical trial

Novel protein construct prevents lethal COVID-19 in mice

Investigating Food Fraud in the Honey Industry

New Phase 1 study evaluates prime/boost HIV-1 vaccine formulated with combinations of adjuvants

UAB researchers find potential new pathway to treating radiation-resistant glioblastoma

The role of nanotechnology in the fight against COVID-19

Research looks at inflammatory nature of lipid nanoparticle component in mRNA vaccines

Event guide: 4th LNP Formulation & Process Development Summit eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

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Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics