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HER2-postive breast cancer drugs show promise for bile duct cancer treatment

Drugs designed to target HER2-postive breast cancer could also benefit some patients with bile duct cancer, according to results of a patient trial to be presented on Thursday at the 36th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain.

23 Oct 2024

New antibody targets cancer-causing HER2 mutations

For some proteins, a single mutation, or change in its DNA instructions, is all it takes to tip the balance between functioning normally and causing cancer.

22 Oct 2024

Distinct fecal metabolites identified for non-invasive diagnosis of endometriosis

Researchers identify distinct gut microbiome metabolites in women with endometriosis, offering potential for non-invasive diagnosis and new therapies.

14 Oct 2024

CKMT2 regulates mitochondrial function and energy metabolism in type 2 diabetes

Creatine kinase M2 (CKMT2) plays a key role in mitochondrial dysfunction in type 2 diabetes, affecting energy metabolism in skeletal muscle.

10 Oct 2024

New surgical stitches capable of generating electrical charge may accelerate wound healing

Researchers developed the BioES-suture, a bioabsorbable suture that accelerates wound healing through electrical stimulation, showing superior healing outcomes.

10 Oct 2024

The role of geroscience in understanding Alzheimer’s Disease

For more than 30 years, researchers have identified and quantified genetic and lifestyle factors for Alzheimer's Disease (AD) and other dementias. Despite extensive research, the fundamental mechanisms behind these neurodegenerative diseases are still not fully understood, and effective management of AD is taking longer than expected.

10 Oct 2024

Novel antibody shows promise for pain relief in peripheral nerves

Cell surface proteins play a crucial role in cell communication and in sensing changes in the extracellular environment.

9 Oct 2024

Exploring the role of gut microbes in the aging process

Aging is a universal and complex process affecting all organisms, characterized by several genetic hallmarks such as telomere attrition, genomic instability, and epigenetic changes.

9 Oct 2024

Florida breast cancer foundation funds two UCF projects to combat breast cancer

As Breast Cancer Awareness Month begins, two College of Medicine cancer researchers have received statewide grants to support their innovative projects to fight a disease that strikes one in eight American women.

3 Oct 2024

Inflammatory proteins linked to higher risk of endometrial cancer

Study identifies key inflammatory and immune response proteins linked to endometrial cancer risk through both observational and Mendelian Randomization analyses, revealing the roles of IL-6 and HSD11B1.

1 Oct 2024

Study uncovers hidden proteins fueling heart disease and stroke

Researchers identified key proteins linked to cardiovascular disease, highlighting new targets for drug development using genetic and observational analyses in UK and China biobanks.

26 Sep 2024

Perceived stress can directly trigger psoriasis relapse

Innovative research has provided compelling evidence that perceived stress can directly trigger the relapse of psoriatic skin lesions. The study, presented today at the European Academy of Dermatology and Venereology (EADV) Congress 2024, is the first to scientifically validate this connection in vivo.

26 Sep 2024

New pipeline of drug candidates offers hope for effective MASLD treatments

Non-alcoholic fatty liver disease (NAFLD), recently reclassified as metabolic dysfunction-associated steatotic liver disease (MASLD), has become the most prevalent chronic liver disease globally.

25 Sep 2024

Neuroactive drugs show promising anti-glioblastoma effects in preclinical trials

Study explores the potential to repurpose neuroactive drugs, originally approved for neurological disorders, for the treatment of glioblastoma. Vortioxetine, an antidepressant, showed promising anti-glioblastoma activity, significantly reducing tumor size in preclinical trials.

24 Sep 2024

Hypothalamic ECM remodeling drives insulin resistance, contributing to obesity and diabetes

Researchers have discovered that remodeling of extracellular matrix (ECM) in the hypothalamus, specifically around AgRP neurons, drives insulin resistance and metabolic disease. Disrupting this ECM buildup improves insulin sensitivity and may be a promising treatment for obesity and diabetes.

19 Sep 2024

FORT-2 trial shows promising results for bladder cancer immunotherapy combination

Findings from the international FORT-2 clinical trial showed that a combination treatment including immunotherapy is safe and tolerable in patients with locally advanced or metastatic bladder cancer.

19 Sep 2024

Cellular sludge around hunger neurons linked to worsening diabetes and obesity

Investigating ECM changes in the hypothalamus reveals mechanisms behind insulin resistance, offering insights into obesity and metabolic disease treatment.

19 Sep 2024

Researchers discover how oral cancer cells may block the body's immune response

Macquarie University researchers have discovered new information about how oral cancer cells may block the body's immune response. This could lead to better treatments for this aggressive disease.

18 Sep 2024

Microbial-immune interactions in severe asthma: Insights into pathogen dominance and treatment approaches

Researchers assess the airway microbiome and host immune-inflammatory responses to identify treatable aspects of severe asthma.

17 Sep 2024

Activation of PPARβ/δ-AMPK pathway shown to slow liver fibrosis development

A study led by Manuel Vázquez Carrera, group leader at the Diabetes and Associated Metabolic Diseases Networking Biomedical Research Centre (CIBERDEM) at the University of Barcelona, reveals advances in the understanding and treatment of liver fibrosis, a serious complication in the context of metabolic fatty liver disease, also known as MASLD (metabolic dysfunction-associated steatotic liver disease).

17 Sep 2024