Preclinical News and Research

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Insilico Medicine discovers novel preclinical candidate to address idiopathic pulmonary fibrosis

Insilico Medicine has demonstrated a breakthrough in Artificial Intelligence ("AI") and drug discovery -- linking together generative chemistry and biology for the first time -- to discover a novel preclinical candidate addressing idiopathic pulmonary fibrosis ("IPF") and be validated with multiple human cell and animal model experiments.

25 Feb 2021

New center established at NYU Langone Health to expand psychedelic research and training

Philanthropic support from several donors totaling over $10 million will allow NYU Langone Health to advance its already world-renowned reputation in the field of psychedelic medicine through the establishment of a one-of-a-kind center dedicated to expanding research and professional medical training in this resurging field.

24 Feb 2021

Study reveals how cancer cells escape death by lymphocytes

Immunotherapy continues to show exciting promise in more effectively combating several tumor types. Many current strategies focus on ensuring the efficient delivery of active cytotoxic cells directly to tumors.

24 Feb 2021

Study: Abundance of iron can drive cancer cell death in neuroblastoma

Neuroblastoma is a cancer that develops in nerve tissue, most commonly in the glands around the kidneys. The gene MYCN is overexpressed in 20-25% of neuroblastoma, and MYCN-amplified neuroblastoma contributes to a considerable percentage of pediatric cancer-related deaths.

24 Feb 2021

Phase 1 clinical trial shows promising results for monoclonal antibodies against MERS coronavirus

A randomized, placebo-controlled Phase 1 clinical trial of two monoclonal antibodies (mAbs) directed against the coronavirus that causes Middle East respiratory syndrome (MERS) found that they were well tolerated and generally safe when administered simultaneously to healthy adults.

23 Feb 2021

mRNA Therapeutics – Analytical and Bioanalytical Characterization

NewsMed interviews Anette Bak from AstraZeneca about her research on developments in mRNA therapeutics that she will present at Pittcon 2021.

From Pittcon 23 Feb 2021

Scientists use patients' own stem cells to restore function after spinal cord injury

Intravenous injection of bone marrow derived stem cells (MSCs) in patients with spinal cord injuries led to significant improvement in motor functions, researchers from Yale University and Japan report Feb. 18 in the Journal of Clinical Neurology and Neurosurgery.

22 Feb 2021

Some nutritional supplements may help prevent or mitigate COVID-19 severity

A new study in the Journal of dietary supplements shows that nutritional supplements, including several vitamins and the mineral zinc, may be useful in preventing the infection or reducing its severity if caught.

22 Feb 2021

New diagnostic approach to evaluate the skin complications of diabetes mellitus

The multidisciplinary research team published their research "Skin complications of diabetes mellitus revealed by polarized hyperspectral imaging and machine learning" recently in the IEEE transactions on Medical imagining.

22 Feb 2021

Intranasal COVID-19 vaccine candidate preclinically tested at UAB expected to start clinical trial

The Altimmune Inc. vaccine candidate that was tested preclinically at the University of Alabama at Birmingham last year is expected to start patient enrollment for its Phase 1 clinical trial next week.

20 Feb 2021

Hydrogel injection could help repair damage to the heart muscle after heart attack

Researchers at CÚRAM, the SFI Research Centre for Medical Devices based at NUI Galway, and BIOFORGE Lab, at the University of Valladolid in Spain, have developed an injectable hydrogel that could help repair and prevent further damage to the heart muscle after a heart attack event.

19 Feb 2021

Trispecific antibody targets cancer cells, natural killer cells

Several treatments for cancer have been devised by science, but unfortunately none of them are completely efficient or foolproof.

19 Feb 2021

New proton therapy targets treatment-resistant cancer cells

Mayo Clinic researchers have developed a novel proton therapy technique to more specifically target cancer cells that resist other forms of treatment.

18 Feb 2021

Advancements in DNA vaccines against COVID-19

The rapid spread of the pathogen and the increasing number of cases highlight the need for an effective and safe vaccine. As vaccination efforts roll out in many countries, new types of vaccines, like deoxyribonucleic acid (DNA) vaccines, are under research..

17 Feb 2021

Mice study suggests novel approach to treat a type of common glioma

Gliomas are common brain tumors that comprise about one third of all cancers of the nervous system. In a study funded by the National Institutes of Health, researchers tested a novel combination treatment approach on mice with tumors with characteristics similar to human astrocytomas--a type of slow-growing glioma--and found tumor regression in 60 percent of the mice treated.

16 Feb 2021

ERS Genomics and ZeClinics sign CRISPR/Cas9 license agreement

ERS Genomics Limited, which was formed to provide broad access to the foundational CRISPR/Cas9 intellectual property co-owned by Dr. Emmanuelle Charpentier, and ZeClinics, a contract research organization using zebrafish to carry out services focused on analyzing the safety, efficacy and biomedical relevance of new compounds, today announced a non-exclusive license agreement granting ZeClinics access to ERS Genomics’ CRISPR/Cas9 patent portfolio.

From ZeClinics SL 16 Feb 2021

New type of surgery can help amputees better control their residual muscles

MIT researchers have invented a new type of amputation surgery that can help amputees to better control their residual muscles and sense where their "phantom limb" is in space.

15 Feb 2021

New zebrafish model could help advance glioblastoma multiforme research

Scientists at the Fralin Biomedical Research Institute at VTC have identified a new zebrafish model that could help advance glioblastoma multiforme research. Glioblastoma is an aggressive form of primary brain tumor - fewer than one in 20 patients survive five years after diagnosis.

13 Feb 2021

Study reveals mechanisms behind sensitivity of multiple myeloma cells to EZH2 inhibition

Researchers from Uppsala University show in a new study that inhibition of the protein EZH2 can reduce the growth of cancer cells in the blood cancer multiple myeloma.

13 Feb 2021

Study describes mechanism that limits immunosupressive activity of tumor-associated macrophages

Tumor cells are able to avoid the attack of the immune system through several mechanisms. For instance, these can secrete factors that turn macrophages -cells in the immune system- into dual action agents that contribute to the tumor progress and will protect it from immune body defenses: these become, thus, the tumor-associated macrophages (TAMs).

13 Feb 2021

Preclinical News and Research

Insilico Medicine discovers novel preclinical candidate to address idiopathic pulmonary fibrosis

New center established at NYU Langone Health to expand psychedelic research and training

Study reveals how cancer cells escape death by lymphocytes

Study: Abundance of iron can drive cancer cell death in neuroblastoma

Phase 1 clinical trial shows promising results for monoclonal antibodies against MERS coronavirus

mRNA Therapeutics – Analytical and Bioanalytical Characterization

Scientists use patients' own stem cells to restore function after spinal cord injury

Some nutritional supplements may help prevent or mitigate COVID-19 severity

New diagnostic approach to evaluate the skin complications of diabetes mellitus

Intranasal COVID-19 vaccine candidate preclinically tested at UAB expected to start clinical trial

Hydrogel injection could help repair damage to the heart muscle after heart attack

Trispecific antibody targets cancer cells, natural killer cells

New proton therapy targets treatment-resistant cancer cells

Advancements in DNA vaccines against COVID-19

Mice study suggests novel approach to treat a type of common glioma

ERS Genomics and ZeClinics sign CRISPR/Cas9 license agreement

New type of surgery can help amputees better control their residual muscles

New zebrafish model could help advance glioblastoma multiforme research

Study reveals mechanisms behind sensitivity of multiple myeloma cells to EZH2 inhibition

Study describes mechanism that limits immunosupressive activity of tumor-associated macrophages

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