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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Study provides deeper insights into skeletal muscle aging

A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by Medline/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 23, entitled, "Single nuclei profiling identifies cell specific markers of skeletal muscle aging, frailty, and senescence."

16 Dec 2022

Mucosal DNA vaccine provides protection against lethal SARS-CoV-2 in mice

Less known to the general public, mucosal vaccination via the mucus membranes could provide robust protection against SARS-CoV-2 infections.

16 Dec 2022

Study shows SARS-CoV-2 infection, replication and persistence in human brain tissues

Researchers investigated the cellular tropism, replication competence, persistence and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans, and associated histopathological changes in infected tissues.

16 Dec 2022

NEJM study shows hidden genetic anomaly behind common late-onset cerebellar ataxia

Researchers at the University of Miami Miller School of Medicine, McGill University and other institutions have found that a well-concealed genetic variation in the gene FGF14, called a DNA tandem repeat expansion, causes a common form of late-onset cerebellar ataxia, a brain disorder that interferes with coordinated movement.

16 Dec 2022

Study provides new insights into the pathology of LATE

Limbic predominate age-related TDP-43 encephalopathy or LATE is a recently recognized form of dementia that affects memory, thinking and social skills. It mimics Alzheimer's disease or AD (and sometimes co-exists with it), but LATE is a different condition, with its own risks and causes.

16 Dec 2022

Adding Gli1+ cells could regenerate the enthesis after rotator cuff surgery

In the annals of shoulder surgery, NFL quarterback Drew Brees is an anomaly. In 2005, Brees was tackled and the rotator cuff tendon in his throwing shoulder was severely torn, a potentially career-ending injury.

16 Dec 2022

Ceramide blockers prevent the loss of muscle mass during aging in mice

During aging, mice, like humans, become inactive and lose muscle mass and strength. A team of scientists led by Johan Auwerx at EPFL have now discovered that when mice age, their muscles become packed with ceramides.

16 Dec 2022

mRNA vaccine methodologies: Production, value and spectrometer use

To be decided by the editor

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 16 Dec 2022

Researchers identify a new target gene in pancreatic ductal adenocarcinoma

Pancreatic cancer remains one of the deadliest malignancies worldwide. Since five-year survival rate for pancreatic ductal adenocarcinoma (PDAC) is only about 3% in patients, PDAC is very difficult to treat with surgery worldwide.

16 Dec 2022

Scientists identify a novel epitope at the SARS-CoV-2 spike furin cleavage site

Scientists identify an immunogenic epitope at the furin cleavage site of the SARS-CoV-2 spike protein.

15 Dec 2022

New immunosensor could be a fast, inexpensive, and convenient tool to detect COVID-19

A new immunosensor based on Quenchbody technology shows great potential as a fast, inexpensive, and convenient tool to detect SARS-CoV-2.

15 Dec 2022

Exploring dynamics of emergence and spread of SARS-CoV-2 variants of concern

Researchers evaluated the emergence and spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in Canada.

15 Dec 2022

Study lays the groundwork for developing new technologies to detect neurodegenerative diseases

Researchers from the Neurobiology of miRNA team coordinated by Davide De Pietri Tonelli at the Istituto Italiano di Tecnologia (IIT-Italian Institute of Technology) has discovered the correlation between a class of small RNA molecules, piRNAs, and brain inflammation.

15 Dec 2022

mRNA-FISH for the detection of viral RNA in SARS-CoV-2 infected cells and the determination of the kinetics of early RNA replication

Researchers evaluated the early replication kinetics of SARS-CoV-2.

15 Dec 2022

Olfactory viral inflammation may accelerate the onset of Alzheimer’s disease

Viruses can inflame and disrupt connections between the olfactory system, which governs the sense of smell, and the part of the brain associated with memory and learning, possibly accelerating the onset of Alzheimer’s disease, according to a new study from researchers at the University of Colorado Anschutz Medical Campus.

15 Dec 2022