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Study shows how a critical Lassa virus protein drives infection

Lassa fever is a viral illness that is far too common in West Africa. Although it can have a mortality rate of 15 percent in severe cases, up to 90% in pregnant women, and causes deafness in a quarter of survivors, there is no vaccine or antiviral to protect against Lassa virus.

19 Jul 2022

Scientists explore guanine-specific pocket in SARS-CoV-2 nucleocapsid protein of therapeutic value against multiple coronaviruses

Researchers studied open and closed conformations of the C-terminal of SARS-CoV-2 nucleocapsid (N) protein termed the NCTD.

19 Jul 2022

Researchers use high-speed atomic force microscopy to explore the binding mechanism of cadherins

Cell, tissue, and organ structure is maintained by cell-cell adhesion molecules that connect opposing cells. Cadherins are a class of essential cell-cell adhesion molecules for tissue formation and integrity, and defects in cadherin function cause various diseases (e.g., cancer invasion).

19 Jul 2022

Researchers develop new SERS method for active capture of target molecules

Recently, a team led by Prof. Yang Liangbao from Hefei Institutes of Physical Science, Chinese Academy of Sciences used the nano-capillary pumping action to automatically capture the target molecules into a smaller gap and achieve highly sensitive Surface-Enhanced Raman Spectroscopy (SERS) detection by constructing a multilayer nanoparticle film to form a natural gap of less than 3 nm between the layers.

19 Jul 2022

DNA may act as nutritional source for E. coli

Findings of a new experiment could be helpful in understanding how DNA acts as a nutrient for gut bacteria, and its impact on the health of the host.

18 Jul 2022

Scientists develop an improved pharmaceutical drug for the treatment of atrial fibrillation

Scientists from the National University of Singapore Department of Pharmacy have developed an improved pharmaceutical drug for the treatment of the most common heart rhythm disturbance – atrial fibrillation (AF).

18 Jul 2022

The role of FTIR in protein analysis and biomedical applications

Professor Dr. Werner Mantele is the Professor of Biophysics at Goethe University and Frankfurt University. With over 30 years of experience with spectroscopy, Dr. Mantele is an internationally-recognized expert in the analysis and detection of molecules.

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 18 Jul 2022

Unique tool helps to study how the mechanical forces behind protein folding affect cancer spread

Talin is a protein that controls cellular attachment and movement, but its malfunctioning also allows cancer cells to spread. DCL1 is a tumor-suppressing protein. But scientists don't fully understand how either protein works – or what happens when they don't work the way they should.

15 Jul 2022

Proteins' wobbles, shakes and quivers play a key role in their ability to function

Johns Hopkins Medicine scientists report they have probed the atomic structure of proteins to add to evidence that the wobbles, shakes and quivers of proteins play a critical role in their ability to function.

15 Jul 2022

Tokyo Tech researchers develop the first synthetic mechanosensitive potassium channel

Intrigued by the properties of ion channel proteins commonly observed in cells, Tokyo Tech researchers have developed the first synthetic mechanosensitive potassium channel using a newly developed aromatic fluorinated amphiphilic cyclophane.

15 Jul 2022

Men with hematopoietic mosaic loss of Y chromosome have worse prognosis for heart failure

research group led by Dr. Soichi Sano, a specially appointed lecturer in the Department of Cardiovascular Medicine, Graduate School of Medicine, Osaka Metropolitan University, revealed that men with hematopoietic mosaic loss of Y chromosome (mLOY) — meaning men with an increase, in the blood, of cells that have lost the male sex chromosome — have a worse prognosis for heart failure due to fibrosis progression in the heart.

15 Jul 2022

Moffitt researchers reveal how RNA molecules promote the development of melanoma metastasis

Changes in DNA can lead to the development and progression of cancer. DNA serves as a template for an intermediary molecule called RNA that, in turn, codes for proteins that control all cellular processes.

15 Jul 2022

New anticoagulant platform holds promise as a revolutionary advancement over the current blood thinners

While blood clotting is important to prevent blood loss and for our immunity, coagulation also can cause health issues and even death. Currently, one in four people worldwide dies from diseases and conditions caused by blood clots.

15 Jul 2022

Novel technique could offer an improved route to drug discovery and development

A new technique that can analyze how drug molecules bind to proteins in tissue samples could offer an improved route to drug discovery and development.

14 Jul 2022

Study describes biochemical pathway that leads to inflammation characteristic of autoimmune diseases

Mitochondria are self-contained organelles (they possess their own mini-chromosome and DNA) residing within cells and are charged with the job of generating the chemical energy needed to fuel functions essential to life and well-being.

13 Jul 2022

New underlying cause of Wiskott-Aldrich syndrome discovered

Researchers at the Salk Institute and King Abdullah University of Science and Technology (KAUST) in Saudi Arabia have discovered a new underlying cause of Wiskott-Aldrich syndrome, a rare genetic disease that leads to bleeding and immune deficiencies in babies.

13 Jul 2022

New approach could pave the way for development of pan-coronavirus antivirals

To put the COVID-19 pandemic in the rearview mirror and prevent other coronaviruses from causing havoc, the world needs an arsenal of measures to prevent and treat these infections.

13 Jul 2022

Ancestral molecule from bacteria-like cells may offer evolutionary insight on sexual reproduction

A study from Karolinska Institutet in Sweden, among others, presents the theory that egg-sperm fusion, a crucial feature of sexual reproduction in plants and animals, may have originated from an ancient form of genetic exchange that involved the fusion of bacteria-like microorganisms called archaea.

12 Jul 2022

Breastfeeding provides an immune boost that helps infants to fight off infectious diseases

When infants breastfeed, they receive an immune boost that helps them fight off infectious diseases, according to recent research from Binghamton University Associate Professor of Anthropology Katherine Wander.

12 Jul 2022

DNA must be enormously compressed in sperm cells, study says

If you are moaning once again about your suitcase being far too small as your vacation approaches, you should take human sperm cells as an inspiration.

11 Jul 2022

Molecule News and Research

Study shows how a critical Lassa virus protein drives infection

Scientists explore guanine-specific pocket in SARS-CoV-2 nucleocapsid protein of therapeutic value against multiple coronaviruses

Researchers use high-speed atomic force microscopy to explore the binding mechanism of cadherins

Researchers develop new SERS method for active capture of target molecules

DNA may act as nutritional source for E. coli

Scientists develop an improved pharmaceutical drug for the treatment of atrial fibrillation

The role of FTIR in protein analysis and biomedical applications

Unique tool helps to study how the mechanical forces behind protein folding affect cancer spread

Proteins' wobbles, shakes and quivers play a key role in their ability to function

Tokyo Tech researchers develop the first synthetic mechanosensitive potassium channel

Men with hematopoietic mosaic loss of Y chromosome have worse prognosis for heart failure

Moffitt researchers reveal how RNA molecules promote the development of melanoma metastasis

New anticoagulant platform holds promise as a revolutionary advancement over the current blood thinners

Novel technique could offer an improved route to drug discovery and development

Study describes biochemical pathway that leads to inflammation characteristic of autoimmune diseases

New underlying cause of Wiskott-Aldrich syndrome discovered

New approach could pave the way for development of pan-coronavirus antivirals

Ancestral molecule from bacteria-like cells may offer evolutionary insight on sexual reproduction

Breastfeeding provides an immune boost that helps infants to fight off infectious diseases

DNA must be enormously compressed in sperm cells, study says

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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