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Researchers identify novel cellular entry factor for AAV vector types

Researchers led by a team at Massachusetts Eye and Ear have identified a novel cellular entry factor for adeno-associated virus vector (AAV) types--the most commonly used viral vectors for in vivo gene therapy. AAVs are vectors-or vehicles--that are created from a virus that is made harmless by molecular engineering, and have shown promise transporting genetic therapy treatments to affected tissues.

23 Jan 2020

Reelin can reverse the main pathological processes associated with Alzheimer's, other tauopathies

Promoting the signaling pathway of reelin -an essential extracellular protein for the neuronal migration and synaptic plasticity- could be an effective therapeutical strategy to counterbalance the main cognitive, biochemical and behavioral alterations seen in Alzheimer's and other pathologies associated with Tau protein, as shown in a new study with animal models -published in the journal Progress in Neurobiology.

23 Jan 2020

Scientists reverse HIV latency, take major scientific step toward curative therapies

Approximately 38 million people are infected with HIV worldwide, about 1.1 million people in the United States. Currently, people with HIV take antiretroviral therapy (ART), which can suppress HIV to undetectable levels in blood, but the virus persists throughout the body in latently infected resting CD4+ T cells.

22 Jan 2020

Discovery of new killer T-cell offers hope of a 'one-size-fits-all' cancer therapy

Researchers at Cardiff University have discovered a new type of killer T-cell that offers hope of a "one-size-fits-all" cancer therapy.

21 Jan 2020

Antiviral compound from banana plants shows potential for clinical use against influenza

What keeps most infectious disease researchers up at night aren't infamous viruses like Ebola. Instead, influenza, commonly known as the flu, continues to be a clear and present danger to humanity.

21 Jan 2020

Linkam automated temperature-controlled stage supports TASC method for rapid screening of drug-polymer miscibility

A new, simplified hot stage microscopy-based method, thermal analysis by structure characterization, has successfully been used to screen the miscibility of drug-polymer combinations.

20 Jan 2020

'Methylation clock' gene found to have functional role in aging of the eye

A lengthy-named gene called Elongation of Very Long Chain Fatty Acids Protein 2 or ELOVL2 is an established biomarker of age.

16 Jan 2020

Study shows superior functionality of Duodenum Intestine-Chip populated with organoids

Emulate, Inc. announced today a published study in collaboration with Johns Hopkins University School of Medicine, that demonstrated superior functionality of the Duodenum Intestine-Chip populated with organoids, compared to organoids alone.

14 Jan 2020

Protein SV2A levels could explain poor neuronal connections in schizophrenia

A team of researchers have found that persons with schizophrenia may have lower levels of certain specific proteins that show up on their brain scans. This could help as diagnostic tools, say experts. The new study titled, “Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats”, is published in the latest issue of the journal Nature Communications.

14 Jan 2020

Genes determining the browning of white fat finds study

The fat cells of the body play an essential role in the storage of energy and its release when necessary. Research has shown that apart from energy storage, these adipocytes or fat cells also play a role in hormonal balance and metabolism-regulating hunger. A new study titled, “Systems-genetics-based inference of a core regulatory network underlying white fat browning”, was published in the latest issue of the journal Cell Report.

13 Jan 2020

New wireless, light-activated electrode advances neural stimulation

Neural stimulation is a pioneering technology that can be used to recover function and improve the quality of life for individuals who suffer from brain injury or disease.

9 Jan 2020

Researchers discover genes that could explain the Browning ability of white fat

Our fat cells, technically referred to as adipocytes, play an essential role in regulating energy balance in our body.

9 Jan 2020

ToxPoint article highlights alternative mechanism to bring focus to major issues in toxicology

The new year has brought with it advances to the Society of Toxicology's official journal, Toxicological Sciences, some of which are reflected in the January 2020 issue - Volume 173, Issue 1.

9 Jan 2020

Study may provide novel targetable mechanisms of therapeutic resistance to anti-VEGF therapies

To establish a molecular signature of this resistance in ovarian cancer, the authors developed preclinical tumor models of adaptive resistance to chronic anti-VEGF treatment.

8 Jan 2020

Immune cells could help kill cancer cells, finds study

Researchers from UCL Cancer Institute have found that a subset of immune cells can kill cancer cells when activated.

8 Jan 2020

New drug compounds thwart master regulator of tumor growth, metastasis

Scientists have developed new drug compounds that thwart the pro-cancer activity of FOXM1, a transcription factor that regulates the activity of dozens of genes.

7 Jan 2020

Scientists uncover new types of brain activity that may be key to human intelligence

A team of scientists has revealed evidence that human brains may be even more powerful than we anticipated.

7 Jan 2020

Daily aspirin use may help prevent colorectal cancer

A new study has shown that regular use of aspirin may protect against heart disease, reduce colorectal tumor growth and prevent relapse.

7 Jan 2020

Researchers study new immunogenic properties of already existing anti-cancer drugs

The world scientific community is waging a difficult and prolonged war on cancer. New research in the field of immunogenic cell death can extend the area of drugs application and ensure patients' protection from relapse after therapy.

3 Jan 2020

New radiotracer can provide insights into how the heart recovers after myocardial infarction

Insights into how the heart recovers after myocardial infarction (heart attack) can be obtained with a new radiotracer that targets fibroblast activity prior to it causing permanent damage.

2 Jan 2020

in vivo News and Research

Researchers identify novel cellular entry factor for AAV vector types

Reelin can reverse the main pathological processes associated with Alzheimer's, other tauopathies

Scientists reverse HIV latency, take major scientific step toward curative therapies

Discovery of new killer T-cell offers hope of a 'one-size-fits-all' cancer therapy

Antiviral compound from banana plants shows potential for clinical use against influenza

Linkam automated temperature-controlled stage supports TASC method for rapid screening of drug-polymer miscibility

'Methylation clock' gene found to have functional role in aging of the eye

Study shows superior functionality of Duodenum Intestine-Chip populated with organoids

Protein SV2A levels could explain poor neuronal connections in schizophrenia

Genes determining the browning of white fat finds study

New wireless, light-activated electrode advances neural stimulation

Researchers discover genes that could explain the Browning ability of white fat

ToxPoint article highlights alternative mechanism to bring focus to major issues in toxicology

Study may provide novel targetable mechanisms of therapeutic resistance to anti-VEGF therapies

Immune cells could help kill cancer cells, finds study

New drug compounds thwart master regulator of tumor growth, metastasis

Scientists uncover new types of brain activity that may be key to human intelligence

Daily aspirin use may help prevent colorectal cancer

Researchers study new immunogenic properties of already existing anti-cancer drugs

New radiotracer can provide insights into how the heart recovers after myocardial infarction

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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