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Studying Alzheimer’s and Parkinson’s Disease using Pre-Formed Fibrils

Ariel Louwrier discusses the development of pre-formed tau and alpha-synuclein fibrils for research into Alzheimer's and Parkinson's disease.

From StressMarq Biosciences Inc. 2 Jan 2020

Tau-protein better predicts brain atrophy in Alzheimer's patients than amyloid plaques

Brain imaging of pathological tau-protein "tangles" reliably predicts the location of future brain atrophy in Alzheimer's patients a year or more in advance, according to a new study by scientists at the UC San Francisco Memory and Aging Center. In contrast, the location of amyloid "plaques," which have been the focus of Alzheimer's research and drug development for decades, was found to be of little utility in predicting how damage would unfold as the disease progressed.

2 Jan 2020

Scientists identify molecules capable of inhibiting DNA methylation, effectively killing malaria parasites

Parasites in the genus Plasmodium, which cause malaria, are transmitted to humans through bites from infected mosquitoes.

31 Dec 2019

Scientists discover potential drug compounds that target common type of liver cancer

Scientists from the Cancer Science Institute of Singapore at the National University of Singapore, and the Agency for Science, Technology and Research (A*STAR)'s Genome Institute of Singapore have discovered four potential drug compounds that target hepatocellular carcinoma, the most common type of liver cancer.

30 Dec 2019

A new deep learning approach to predict disease-associated mutations

During the past years, artificial intelligence (AI) -- the capability of a machine to mimic human behavior -- has become a key player in high-techs like drug development projects.

28 Dec 2019

Synthetic mRNA nanoparticles restore tumor suppressor gene, make cancer cells susceptible to drugs

In preclinical experiments, investigators restored p53 using synthetic mRNA nanoparticles, making lung and liver cancer cells susceptible to available cancer drugs.

23 Dec 2019

New technique provides real-time images of biomolecules in living cells

Metabolic diseases such as diabetes and obesity are ever more common globally. In addition to genetic disposition, lifestyle contributes strongly to the prevalence of these metabolic diseases.

23 Dec 2019

Moffitt researchers develop efficient method for creating mouse models to study melanoma

Genetically engineered mouse models are often used by scientists to study how the addition, deletion or mutation of genes affects the development of disease and effects of drugs.

17 Dec 2019

The Acoustics of the Brain: Random-access 3D Microscopy in Neuroscience

Máté Marosi and Zsolt Iván discuss the use of acousto-optic microscopes to study neural networks in the brain, from cell bodies to dendrites, to tiny spines.

From Femtonics Ltd. 17 Dec 2019

New fabrication method for silk shows promise for use in biomedical devices

Researchers led by engineers at Tufts University have developed a novel, significantly more efficient fabrication method for silk that allows them to heat and mold the material into solid forms for a wide range of applications, including medical devices.

17 Dec 2019

CSHLP releases new book on 'Metastasis: Mechanism to Therapy'

Cold Spring Harbor Laboratory Press announced the release of Metastasis: Mechanism to Therapy, available on its website in Hardcover format.

14 Dec 2019

New bandage soaks up pro-healing molecule to improve bone repair

Researchers at Duke University have engineered a bandage that captures and holds a pro-healing molecule at the site of a bone break to accelerate and improve the natural healing process.

14 Dec 2019

Finding non-invasive nuclear medicine technique to predict effectiveness of therapy for tumors

Researchers have taken a critical step toward developing a non-invasive nuclear medicine technique that can predict the effectiveness of therapy for cancerous tumors, allowing for personalized, precision treatment.

13 Dec 2019

DigiM Solution receives FDA contract for microstructure imaging study

DigiM Solution LLC, a provider of microstructure characterization and optimization solutions and software, has received a contract from the Office of Generic Drugs of the U.S. Food and Drug Administration.

From DigiM Solution LLC 13 Dec 2019

Study shows unexpected mechanism for lipid acquisition by breast cancer cells

High-fat diets and obesity have been shown to increase the risk of breast cancer and worsen outcomes and prognosis of breast cancer patients. A team of researchers from Dartmouth and Dartmouth-Hitchcock Norris Cotton Cancer Center led by William Kinlaw III, MD, sought to understand how fat from the diet might influence breast cancer cells.

12 Dec 2019

Novel self-powered, neural-stimulating e-skin for characterization of synaptic plasticity

Chinese scientists recently developed a flexible electronic skin (e-skin) capable of self-powered neural stimulation and inducing a neural response. The technology will be useful in characterizing synaptic plasticity.

12 Dec 2019

Researchers develop new bio-platform to hear the beat of small clusters of cells

One of the tests that almost every patient must face before a surgery or other health intervention is an electrocardiogram.

11 Dec 2019

Researchers use stem cells to create in-vitro 3D neural tissue model

Researchers at the University of Illinois at Urbana-Champaign have successfully used stem cells to engineer living biohybrid nerve tissue to develop 3D models of neural networks with the hopes of gaining a better understanding of how the brain and these networks work.

11 Dec 2019

Stilla Technologies announces key leadership hires

Stilla Technologies, the provider of pioneering digital PCR solutions for high-precision genetic analysis, today announced three key hires: Khaled Bahi joins as CFO, with Jerome Leclercq named Senior Vice President for Commercial Operations Europe & Asia and Quang Tran named Quality & Regulatory Affairs Director.

11 Dec 2019

New method to create artificial cells that are active and mimic living cells

Protocells - artificial cells - that are active and mimic living cells by moving independently and that are biocompatible and enzymatically active are now possible using an improved method developed by Penn State researchers.

9 Dec 2019

in vivo News and Research

Studying Alzheimer’s and Parkinson’s Disease using Pre-Formed Fibrils

Tau-protein better predicts brain atrophy in Alzheimer's patients than amyloid plaques

Scientists identify molecules capable of inhibiting DNA methylation, effectively killing malaria parasites

Scientists discover potential drug compounds that target common type of liver cancer

A new deep learning approach to predict disease-associated mutations

Synthetic mRNA nanoparticles restore tumor suppressor gene, make cancer cells susceptible to drugs

New technique provides real-time images of biomolecules in living cells

Moffitt researchers develop efficient method for creating mouse models to study melanoma

The Acoustics of the Brain: Random-access 3D Microscopy in Neuroscience

New fabrication method for silk shows promise for use in biomedical devices

CSHLP releases new book on 'Metastasis: Mechanism to Therapy'

New bandage soaks up pro-healing molecule to improve bone repair

Finding non-invasive nuclear medicine technique to predict effectiveness of therapy for tumors

DigiM Solution receives FDA contract for microstructure imaging study

Study shows unexpected mechanism for lipid acquisition by breast cancer cells

Novel self-powered, neural-stimulating e-skin for characterization of synaptic plasticity

Researchers develop new bio-platform to hear the beat of small clusters of cells

Researchers use stem cells to create in-vitro 3D neural tissue model

Stilla Technologies announces key leadership hires

New method to create artificial cells that are active and mimic living cells

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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