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Inhibition of a protease could improve the treatment of IBD, study shows

Scientists at the Centro Nacional de Investigaciones Cardiovasculares and the Centro de Investigaciones Biológicas of the Consejo Superior de Investigaciones Científicas have identified the protease MT1-MMP as a possible future target for drugs to treat inflammatory bowel disease.

3 Dec 2019

Streamlining Immuno-Oncological Therapeutic Antibody Discovery

The growing trend of implementing immunotherapy into oncology has resulted in various new therapeutic cancer treatments utilizing antibodies.

From Sartorius 3 Dec 2019

Study: Calcium signaling can help address drug resistance to non-Hodgkin lymphoma

Gene expression profiling and other analyses conducted by Rutgers Cancer Institute of New Jersey researchers and colleagues examining drug resistance to a common antibody therapy for non-Hodgkin lymphoma have identified calcium signaling as a novel and exploitable target in overcoming this treatment obstacle.

3 Dec 2019

Study: TBK1 protein promotes cancer development, suppresses immune response to the disease

Researchers at The University of Texas MD Anderson Cancer Center have found that a protein involved in immune response to microbes also can fuel cancer development and suppress immune response to the disease.

3 Dec 2019

Research lays foundation for patient-specific 3D-printed meniscus

The human knee joint is the largest and complex joint in the body compared to other joints. It has various hard and soft tissue elements to provide stability and proper functioning including the meniscus.

2 Dec 2019

Scientists sheds light on small protein and its role in immune response

The immune system is the body’s defense against disease-causing pathogens. It works by warding off disease and potentially-damaging foreign bodies. Now, a team of researchers have developed a new method to shed light on the basic defense mechanism of the immune system.

27 Nov 2019

Oligomerix and Feinstein Institutes publish preclinical data of Alzheimer's disease treatment

Oligomerix, Inc., a privately held company pioneering the development of tau oligomer inhibitors for Alzheimer's disease and related neurodegenerative disorders, and the Feinstein Institutes for Medical Research announced today the publication of preclinical data demonstrating that an oral small molecule drug inhibits the formation of neurotoxic tau oligomers in an animal model of tau aggregation most relevant to AD.

26 Nov 2019

Novoheart collaborates with AstraZeneca to develop world’s first human heart-in-a-jar model of heart failure

Novoheart, a global stem cell biotechnology company, is pleased to announce a collaboration with global biopharmaceutical company AstraZeneca, in an effort to develop the world’s first human-specific in vitro, functional model of heart failure with preserved ejection fraction (HFpEF), a common condition especially among the elderly and in women, with the reported prevalence approaching 10% in women over the age of 80 years.

26 Nov 2019

Apoptosis protein API-5 more markedly expressed in chemoresistant triple-negative breast cancer

78 TNBC biopsies from patients with different responses to chemotherapy were analysed for API-5 expression before any treatment.

25 Nov 2019

Researchers assess safety of conditionally immortalized cells for bioartificial kidney application

Here, the research team assessed the safety of conditionally immortalized proximal tubule epithelial cells for bioartificial kidney application, by using in vitro assays and athymic nude rats.

25 Nov 2019

PREDiCT: Tumor Models San Francisco Summit 2020

The community of preclinical immuno-oncology scientific Pharma and Biotechs meet again to advance their preclinical insights through robust models utilization to accelerate IO development & clinical confidence.

25 Nov 2019

Special protective membrane reduces build-up of fibrotic tissue around pacemakers

ETH scientists have developed a special protective membrane made of cellulose that significantly reduces the build-up of fibrotic tissue around cardiac pacemaker implants, as reported in the current issue of the journal Biomaterials.

21 Nov 2019

Subpopulations of tumor cells may exhibit diverging behaviors from bulk tumor

Subpopulations of tumor cells may exhibit diverging behaviors from the bulk tumor due to an alternate stress response that diverts tumor cells from apoptotic death.

20 Nov 2019

New database helps identify therapeutic targets to fight infectious diseases

Infectious diseases are caused by pathogenic microorganisms capable of entering, colonizing and growing within a host organism, thus producing an infection. Bacterial infections have been on the rise worldwide in recent years, but many mechanisms underlying bacterial pathogenesis are still poorly understood.

19 Nov 2019

New technology may offer alternative means of profiling tissues

Current cancer treatment courses often begin with tissue biopsies. Biopsies, however, which involve the physical resection of a small tissue sample, can lead to localized tissue injury, bleeding, inflammation, and stress, as well as increased risk of metastasis.

19 Nov 2019

TARA's organ-on-a-chip technology can directly measure in vivo cardiac performance, study shows

TARA Biosystems, Inc. today reported in vivo and in vitro functional data from a study of investigational candidate, MYK-491, showing that TARA's human iPSC-derived organ-on-a-chip technology can directly measure in vivo cardiac performance.

18 Nov 2019

Blocking a molecule could delay the progression of multiple sclerosis

Over 77,000 Canadians are living with multiple sclerosis, a disease whose causes still remain unknown. Presently, they have no hope for a cure.

14 Nov 2019

Clinical analysis reveals high expression of apoptosis protein in chemoresistant TNBC

78 TNBC biopsies from patients with different responses to chemotherapy were analysed for API-5 expression before any treatment.

13 Nov 2019

Deep neural network could improve cancer care

Improving the detection, diagnosis, and treatment of diseases like cancer will require more detailed, rapid, and agile imaging technology that can show doctors not just what a specific organ looks like, but also what's happening within the cells that make up those tissues.

13 Nov 2019

Virginia Tech professor wins $1.85 million NIH grant for sepsis research

One drop of blood contains 5,000 neutrophils, the most abundant type of white blood cell that is deployed by the human immune system. Throughout the entire body, a human has 25 billion of these foot soldiers that are relentlessly patrolling to fight invading pathogens.

12 Nov 2019

in vivo News and Research

Inhibition of a protease could improve the treatment of IBD, study shows

Streamlining Immuno-Oncological Therapeutic Antibody Discovery

Study: Calcium signaling can help address drug resistance to non-Hodgkin lymphoma

Study: TBK1 protein promotes cancer development, suppresses immune response to the disease

Research lays foundation for patient-specific 3D-printed meniscus

Scientists sheds light on small protein and its role in immune response

Oligomerix and Feinstein Institutes publish preclinical data of Alzheimer's disease treatment

Novoheart collaborates with AstraZeneca to develop world’s first human heart-in-a-jar model of heart failure

Apoptosis protein API-5 more markedly expressed in chemoresistant triple-negative breast cancer

Researchers assess safety of conditionally immortalized cells for bioartificial kidney application

PREDiCT: Tumor Models San Francisco Summit 2020

Special protective membrane reduces build-up of fibrotic tissue around pacemakers

Subpopulations of tumor cells may exhibit diverging behaviors from bulk tumor

New database helps identify therapeutic targets to fight infectious diseases

New technology may offer alternative means of profiling tissues

TARA's organ-on-a-chip technology can directly measure in vivo cardiac performance, study shows

Blocking a molecule could delay the progression of multiple sclerosis

Clinical analysis reveals high expression of apoptosis protein in chemoresistant TNBC

Deep neural network could improve cancer care

Virginia Tech professor wins $1.85 million NIH grant for sepsis research

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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